DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8089 and ZNF107

DIOPT Version :9

Sequence 1:	NP_611014.1	Gene:	CG8089 / 36679	FlyBaseID:	FBgn0033993	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	570	Identity:	123/570 - (21%)
Similarity:	194/570 - (34%)	Gaps:	150/570 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 FWTNEYFKADLQDDFRAIFDAFEEKNRKVQLEKLAAILDTVSSGYRRS----------------- 142
            |..|:|.|         :||.|...||                 |:|.
Human   189 FQCNKYVK---------VFDKFSNSNR-----------------YKRRHTGNKHFKCKECSKSFC 227

  Fly   143 -VSQLAGQEAHGALRPKIAALFLPGLRCDCYKCEN----LPWKKLQDVEDHQKTHRYSDNFHCQI 202
             :|||.   .|..:..::          :.||||.    ..|  ...:..|::.|.....:.|:.
Human   228 VLSQLT---QHRRIHTRV----------NSYKCEECGKAFNW--FSTLTKHKRIHTGEKPYKCEE 277

  Fly   203 CYRRFYLQHSLTSHIIRKSTSSRELHENKRYKRLLENQKSQEEKELELSLNKVEDILVPVAEDLQ 267
            |.:.|.....||.|.|        :|..::..:..|..|:.::.. .|:::|:    :...|...
Human   278 CGKAFNQSSQLTRHKI--------IHTEEKPNKCEECGKAFKQAS-HLTIHKI----IHTGEKPY 329

  Fly   268 SY------FKDESKHPIQK--RKTSSLSKCPSCAQNYGFSFSHQLHMVKHRRERLYTNFPFHCSF 324
            .|      |...|....||  ....:|.||..|.:.:....:...|...|..|:     |:.|..
Human   330 KYEECGKVFSQSSHLTTQKILHTGENLYKCKECGKAFNLFSNLTNHKRIHAGEK-----PYKCKE 389

  Fly   325 CNRSFLTRKFLRKHQQRVRTFSTLLYRPFKCPHCTWRFQLKSALDSHVLRIHERRKPCLICKLPT 389
            |.|:|.....|.| |:::.|...|    .||..|...|.....|.:| .:|....||
Human   390 CGRAFNISSNLNK-QEKIHTGGKL----NKCEECDKAFNRSLKLTAH-KKILMEEKP-------- 440

  Fly   390 SRLCCSAHTSKECNRAMQKY----RDKMRPLREPPKGGCRKQPTPVCKICNRKFTRKFFLEEHMN 450
                   :..:||.:...::    |.|:....|.|.         .||.|.:.|.:...|.|| .
Human   441 -------YKCEECGKVFNQFSTLTRHKIIHTGEKPY---------KCKECGKAFNQSSNLTEH-K 488

  Fly   451 KAHLNKRNFTCEICGANFYSQGTMQTHRKAVHLLVHTVQCEVCDLTIKSKGNYRRHCKSQSHKDN 515
            |.|..::::.||.||..|.....:..||| ::......:||.|...........||.|
Human   489 KIHTAEKSYKCEECGKAFNQHSNLINHRK-IYSGEKPYKCEECGKAFNRSSTLTRHKK------- 545

  Fly   516 LVKFGKNNDKTKDSNR--RKGARTTDEKLDIEASSSTNTCMTSANKSTHNYKKMGIKTKQTHLKT 578
             :..|:...|.::.:|  .:.:..|:.| .|........| ....|:.:.:..:   ||...:.|
Human   546 -IHTGEKPYKCEECDRAFSQSSNLTEHK-KIHTGEKPYKC-EECGKAFNRFSTL---TKHKRIHT 604

  Fly   579 PCRSKKRVKIKICETCGNSIVGSMQ--RH-YRSMKHKLNLMAQ-AKMFKK 624
               .:|..|   ||.||.:...|.|  || ....|.|||...: .|.||:
Human   605 ---GEKPYK---CEECGKAFNQSYQLTRHKIVHTKEKLNKCEEFGKAFKQ 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8089	NP_611014.1	C2H2 Zn finger	289..309	CDD:275368	3/19 (16%)
		C2H2 Zn finger	322..343	CDD:275368	7/20 (35%)
		C2H2 Zn finger	355..376	CDD:275368	5/20 (25%)
		C2H2 Zn finger	432..453	CDD:275368	8/20 (40%)
		C2H2 Zn finger	461..486	CDD:275368	8/24 (33%)
		C2H2 Zn finger	490..506	CDD:275368	3/15 (20%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368	10/45 (22%)
		C2H2 Zn finger	219..239	CDD:275368	4/22 (18%)
		COG5048	243..621	CDD:227381	97/448 (22%)
		C2H2 Zn finger	247..267	CDD:275368	4/21 (19%)
		C2H2 Zn finger	275..295	CDD:275368	7/27 (26%)
		C2H2 Zn finger	303..323	CDD:275368	4/24 (17%)
		C2H2 Zn finger	331..351	CDD:275368	5/19 (26%)
		C2H2 Zn finger	359..379	CDD:275368	3/19 (16%)
		C2H2 Zn finger	387..407	CDD:275368	7/20 (35%)
		C2H2 Zn finger	415..435	CDD:275368	5/20 (25%)
		C2H2 Zn finger	443..463	CDD:275368	4/19 (21%)
		C2H2 Zn finger	471..491	CDD:275368	8/20 (40%)
		C2H2 Zn finger	499..519	CDD:275368	8/20 (40%)
		C2H2 Zn finger	527..547	CDD:275368	6/27 (22%)
		COG5048	551..>863	CDD:227381	27/109 (25%)
		C2H2 Zn finger	555..575	CDD:275368	3/20 (15%)
		C2H2 Zn finger	583..603	CDD:275368	4/23 (17%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		C2H2 Zn finger	639..659	CDD:275368	3/10 (30%)
		C2H2 Zn finger	699..715	CDD:275368
		C2H2 Zn finger	723..743	CDD:275368
		C2H2 Zn finger	751..771	CDD:275368
		C2H2 Zn finger	779..799	CDD:275368
		C2H2 Zn finger	807..827	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	863..883	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142198
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930