DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8089 and CG1647

DIOPT Version :9

Sequence 1:	NP_611014.1	Gene:	CG8089 / 36679	FlyBaseID:	FBgn0033993	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster

Alignment Length:	720	Identity:	126/720 - (17%)
Similarity:	213/720 - (29%)	Gaps:	290/720 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PGK--LLVTYENFTTDL--PVLS-------------IDKKPYGCPASCHCKCKCCRGFREKYVAF 51
            |||  :|:..|..|.||  |.:|             .||.|....:.|..|......|||...|.
  Fly    28 PGKVPILLPNEEDTIDLDEPRMSQKIYELVGFTVSVDDKMPQTICSQCVDKINDFYEFREMCYAT 92

  Fly    52 NGEGETIFGTDFSSELCEDVQKIMRFRSSDMLLLLRTAQLRDNFWTNEYFKADLQDDFRAIFDAF 116
            |.:...:.|                      |..:..|:|.|       .|..:::: |.|..|.
  Fly    93 NKQTRNLLG----------------------LKQIEPARLID-------LKRIVKEE-RPISGAV 127

  Fly   117 EEKNRKVQLEKLAAILDTVSSGYRRSVSQLAGQEA---HGALRPKIAALFLPGLRCDCYKCENLP 178
            .::.||.:                       |:|:   :..::|::             |.|:..
  Fly   128 GKRGRKRK-----------------------GEESWPKNNNVKPQV-------------KKESFV 156

  Fly   179 WKKLQDVEDHQKTHRYSD-------------------------NFHCQICYRRFYLQHSLTSHII 218
            |.|.|.::..|.|...|.                         ...|.:|..:|.
  Fly   157 WHKKQKLQPSQITSLVSKREPEIKDEPAEQDTSLKGPPKKAGRKSICSVCGEKFL---------- 211

  Fly   219 RKSTSSRELHENKRYKRLLENQKSQEEKELELSLNKVEDILVPVAEDLQSYFKDESKHPIQKRKT 283
                 |:||              :.|.|.| :.:..:...:............|...|.:..:.:
  Fly   212 -----SKEL--------------ADEHKSL-VHVPSIPRYICNACNQTHHNQSDIRAHQLWHKLS 256

  Fly   284 SSLSKCPSCAQNYGFSFSHQLHMVKHR-----------RERLYTNFPFHCSFCNRSFLTRKFLRK 337
            .:..|||.|..:...:::...|:.:|.           ||         |..|.::|:|..|...
  Fly   257 KTPYKCPLCESSVANAYAFTRHLREHTPPTPVQLLVLDRE---------CPLCKKTFVTNFFYNT 312

  Fly   338 HQQRV---------RTFST----LLYRPFKCP-----HCTW----------RFQLKSALDSHVLR 374
            |:..:         ||.:|    :.:.| .||     |...          :..:|:.::..:|.
  Fly   313 HRCAIRKRKCGGCSRTLNTEAAYMRHAP-TCPKIYLNHSKHIMPQVVTNEAQMLIKNEIEEELLG 376

  Fly   375 ------------IHERRKPCLICKLPTSRLCCS--------AHTSKECNR-AMQKYRDKMRPLRE 418
                        |.|..:|.::.:..:|.|..|        |..||..:| :.:.|..::..|.:
  Fly   377 LPPATTVPPDFVIDEGMQPVVVLERLSSPLLRSSSGTDQLVAAKSKNSDRVSARNYLKRVDQLLK 441

  Fly   419 ---------------------PPKGGCRKQPTPVCKICNRKFTRKFFLEEHMNKA-HLNKRNFTC 461
                                 ||:|.....|.|     .|.       |||.:.. .:...|..|
  Fly   442 NTINTLVSIKHEPEVHINDTGPPRGQAESDPEP-----ERN-------EEHPSFGDDIQAANDEC 494

  Fly   462 EICGANFYSQGTMQTHRKAVHLLVHTVQCEVCD----LTIKSKGNYRRHCKSQSHKDNLVKF--- 519
            :.|.....|.               .:....||    :::|.:..|..:.|....|...:|.
  Fly   495 QECQPETESD---------------KISVAACDDIPSVSVKQEPEYDGYEKQTGVKQEPLKLKLK 544

  Fly   520 -----GKNNDKTKD-----------SNRRKGARTTDEKLDIEASSSTNTCMTSANKSTHNYKKMG 568
                 ||.|....|           |:::|..|...|: :.|||:.|..|.|.:.      .:..
  Fly   545 ITKNHGKLNSSLIDDLDEAGQAFGRSSKKKKKRKHKER-EKEASNETENCRTESQ------NQPA 602

  Fly   569 IKTKQ 573
            ||.||
  Fly   603 IKIKQ 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8089	NP_611014.1	C2H2 Zn finger	289..309	CDD:275368	4/19 (21%)
		C2H2 Zn finger	322..343	CDD:275368	6/29 (21%)
		C2H2 Zn finger	355..376	CDD:275368	5/47 (11%)
		C2H2 Zn finger	432..453	CDD:275368	4/21 (19%)
		C2H2 Zn finger	461..486	CDD:275368	3/24 (13%)
		C2H2 Zn finger	490..506	CDD:275368	4/19 (21%)
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071	20/70 (29%)
		C2H2 Zn finger	203..224	CDD:275368	9/50 (18%)
		C2H2 Zn finger	233..253	CDD:275368	2/19 (11%)
		C2H2 Zn finger	262..282	CDD:275368	4/19 (21%)
		C2H2 Zn finger	297..314	CDD:275368	5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24406
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100