DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8089 and CG12942

DIOPT Version :9

Sequence 1:	NP_611014.1	Gene:	CG8089 / 36679	FlyBaseID:	FBgn0033993	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_610628.2	Gene:	CG12942 / 36158	FlyBaseID:	FBgn0033569	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	708	Identity:	139/708 - (19%)
Similarity:	229/708 - (32%)	Gaps:	220/708 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DLPVLSIDKKPYGCPASCHCKCKCCRGFREKYVAFNGEGETIFGT-DFSSELCEDVQKIMRFRSS 80
            |..:|:::|...|      .||:.|.....|.|..|.|...:..| .::..|.:.....:|..|.
  Fly     7 DPALLAMNKLNKG------SKCRACLSVDRKTVQLNAEVPNLQKTRTYAQSLKQCTNLDLRVISP 65

  Fly    81 -----DMLLLLRTAQLRDNFWTNEYFKADLQDDFRAIFDAFE------EKNRKVQLEKLAAILDT 134
                 .|.:.:|..                    ||:..|..      |.|.|:|.|..:..|.:
  Fly    66 GGYLWPMQICVRCC--------------------RALEVAMHFVEMALESNLKLQAEAKSVKLPS 110

  Fly   135 VSSGYRRSVSQ---------------LAGQEAHGALRPKIAALFL-----PGLRCDCYKCENLPW 179
            .:...:|..|.               :.|.|  |.:...:  |::     |.|..|.........
  Fly   111 PTGELKRKASNETIPWNQFSQEFEQFVEGYE--GPIEENV--LYMRGTKVPRLDVDASSSSETAP 171

  Fly   180 KK----LQDVE-DHQKTHRYSDNFHCQICYRRFYLQHSLT--SHIIRKSTSSRELHENKRY---- 233
            |:    |.||: |........:|..........:.::|:|  ..::..|.:.:.:..|..|
  Fly   172 KEDEVILFDVKYDTNDLEEEDENDGSDAKNNETFFENSITPGESVMVVSVAEKAVENNNNYNFNN 236

  Fly   234 -------------KRLLE----------NQKSQEEKELELSLNKVEDIL---------------V 260
                         :|.||          :.|::...|.:|..|.:|...               :
  Fly   237 KNGDVTDEECDLIQRALEMTLNDDGCSQSPKNEASNETQLKSNGIEVSSPLFIKLATTSSTTGNI 301

  Fly   261 PV------------AEDLQSYFKDESKHPIQKRKTSSLS-------KCPSCAQNYGFSFSH-QLH 305
            |:            ||.|:.::|  |.|.|...:...:.       ||..|........|. |.|
  Fly   302 PILKCNICQYTHTDAEQLKIHYK--SIHKISMMEDDIIGLNKNQNFKCRPCNSYETKDRSEMQKH 364

  Fly   306 MVKHRR----ERLYTNFPFHCSFCNRSFLTRKFLRKHQQRVRTFSTLLYRP---FKCPHCTWRFQ 363
            ::.|.:    ..:|.....:|..|:|.|..::..|||..||.|...:...|   :.|..|...|.
  Fly   365 LIDHHKIDGDFEMYCYMQANCPACDRIFKDQRSARKHYTRVHTPVQIAVSPTESYACTACDKVFN 429

  Fly   364 LKSALDSHVLRIHERRKPCLICKLPTSRLC-------CSAHTSKECNR---AMQKYRDKMRPLRE 418
            .|::|.||                  .|.|       ||.     |::   :|:||...::.|.
  Fly   430 QKASLHSH------------------QRFCQVKDVVHCSF-----CDQQFNSMRKYELHLQQLH- 470

  Fly   419 PPKGGCRKQPTPVCKICNRKFT--------RKFFLEE-------------------HMNKAHLNK 456
                  ..:....|:||.|.|.        ||...|.                   |..:||:|:
  Fly   471 ------AVETVHECEICRRSFKSAETLTMHRKRHSERHYQCGKCSLNYVNSAELRVHYERAHVNE 529

  Fly   457 RNFTCEICGANFYSQGTMQTHRKAVHLLVHTVQCEVCDLTIKSKGNYRRHCKSQSHKDNLVKFGK 521
            ...:|..||..|.:...::.|.:..|......:||||:...|::...|:|  ...|.|...|..|
  Fly   530 EPVSCLTCGNQFQNMTLLREHEQRSHQKSKVWRCEVCNFETKTRWRRRQH--QYEHMDYPYKCQK 592

  Fly   522 NNDKTKD-------SNRRKGARTTDEKLD---IEASSSTNTCMTSANKSTHNYKKMGI 569
            ...:..|       |.:..|...:||:|.   .|....||. ..:.|||.::.:..|:
  Fly   593 CTSEFADRSKFRQHSKKVHGIELSDEQLAEMFREKKGYTNR-HDAFNKSINSLEIPGL 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8089	NP_611014.1	C2H2 Zn finger	289..309	CDD:275368	5/20 (25%)
		C2H2 Zn finger	322..343	CDD:275368	8/20 (40%)
		C2H2 Zn finger	355..376	CDD:275368	7/20 (35%)
		C2H2 Zn finger	432..453	CDD:275368	9/47 (19%)
		C2H2 Zn finger	461..486	CDD:275368	6/24 (25%)
		C2H2 Zn finger	490..506	CDD:275368	6/15 (40%)
CG12942	NP_610628.2	zf-AD	22..101	CDD:285071	18/98 (18%)
		C2H2 Zn finger	385..406	CDD:275368	8/20 (40%)
		C2H2 Zn finger	421..470	CDD:275368	15/71 (21%)
		C2H2 Zn finger	449..466	CDD:275371	6/21 (29%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		C2H2 Zn finger	505..526	CDD:275368	1/20 (5%)
		C2H2 Zn finger	534..555	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930