DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8089 and Zfp160

DIOPT Version :9

Sequence 1:	NP_611014.1	Gene:	CG8089 / 36679	FlyBaseID:	FBgn0033993	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_663458.2	Gene:	Zfp160 / 224585	MGIID:	108187	Length:	650	Species:	Mus musculus

Alignment Length:	646	Identity:	130/646 - (20%)
Similarity:	213/646 - (32%)	Gaps:	197/646 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TTDLPVLSIDKKP----YGCPASCHCKCKCCRGFREKYVAFNGEGETIFGTDFSSELCEDVQKIM 75
            ::|..:.|.||.|    |...:|...|               |:..||.|..:.   |::..|:.
Mouse   109 SSDKILASGDKAPVVHEYDVYSSLRIK---------------GQKATIKGKPYQ---CKECDKVF 155

  Fly    76 RFRSSDMLLLLRTAQLRDNFWTNEYFKADLQDDFRAIFDAFEEKNRKVQLEKLAAILDTVSSGYR 140
            .:.||    |....|:...                               |||...|:...:.:|
Mouse   156 SYTSS----LAYHRQIHTG-------------------------------EKLYKCLECGKAFFR 185

  Fly   141 RSVSQLAGQEAHGALRPKIAALFLPGLRCDCYKCENL--PWKKLQDVEDHQKTHRYSDNFHCQIC 203
            ||. .|..:..|...:|              |||...  .:.:...::.|::.|.....|.|..|
Mouse   186 RSY-LLVHERHHTGAKP--------------YKCNECGKVFSQNSHLKSHRRIHTGEKPFKCNHC 235

  Fly   204 YRRFYLQHSLTSHIIRKSTSSRELHE-NKRYKRLLENQKSQEEKELELSLNKVEDILVPVAEDLQ 267
            .:.|.::.:||.|.:        :|. :|.||                            ..:..
Mouse   236 GKAFSVRSNLTHHQV--------IHTGDKPYK----------------------------CNECG 264

  Fly   268 SYFKDESKHPIQKRKTSSLS--KCPSCAQNYGFSFSHQLHMVKHRRERLYTNFPFHCSFCNRSFL 330
            ..|...|...|.:|..:...  :|..|.:.:....:...|...|..|:     |:.||.|.:.|.
Mouse   265 KVFSQTSSLTIHRRTHTGEKPYRCNECGKVFSSHSNLNTHQAIHTGEK-----PYKCSECGKVFT 324

  Fly   331 TRKFLRKHQQRVRTFSTLLYRPFKCPHCTWRFQLKSALDSHVLRIHERRKP--CLIC-KLPTSRL 392
            ....|..| .|:.|..    :|:||..|...|.:.|:|.:| ..||...||  |..| |:.|...
Mouse   325 QNSHLANH-WRIHTGE----KPYKCNECGKAFSVYSSLTTH-QAIHTGEKPYKCNECGKVFTQNS 383

  Fly   393 CCSAHTS----------KECNRAMQKYRDKMRPLR-----EPPKGGCRKQPTPVCKICNRKFTRK 442
            ..::|..          :||.:...:..:..|..|     :|.|          |..|.:.|:.:
Mouse   384 HLASHRGVHSGEKPYKCEECGKLFSQTSNLARHWRVHTGEKPYK----------CSECGKAFSVR 438

  Fly   443 FFLEEHMNKAHLNKRNFTCEICGANFYSQGTMQTHRKAVHLLVHT----VQCEVCDLTIKSKGNY 503
            ..|..| ...|..::.:.|..||..|     .||...::|..:||    .:|..|.....|..|.
Mouse   439 SSLIAH-QVIHTGEKPYKCTECGKVF-----SQTSSLSIHQRIHTGEKPYRCNECGKAFNSHSNL 497

  Fly   504 RRHCKSQSHKDNLVKFGKNNDK--------TKDSNRRKGART-TDEK----------LDIEASSS 549
            ..|        .::..|:...|        |::|:.....|| |.||          ..:.:|.:
Mouse   498 NTH--------QVIHTGQKPYKCMQCGKVFTQNSHLANHQRTHTGEKPYKCNECGKAFSVYSSLT 554

  Fly   550 TNTCMTSANKSTHNYK--KMG-IKTKQTHLKTPCRSKKRVKIKICETCGN--SIVGSMQRH 605
            |:..:.:..|.   ||  :.| :.|:.:||.:..|:....|...|..|..  |:..|:..|
Mouse   555 THQAIHTGEKP---YKCNECGKVFTQNSHLASHRRTHTGEKPYQCNKCDKAFSVRSSLTTH 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8089	NP_611014.1	C2H2 Zn finger	289..309	CDD:275368	3/19 (16%)
		C2H2 Zn finger	322..343	CDD:275368	7/20 (35%)
		C2H2 Zn finger	355..376	CDD:275368	6/20 (30%)
		C2H2 Zn finger	432..453	CDD:275368	5/20 (25%)
		C2H2 Zn finger	461..486	CDD:275368	7/24 (29%)
		C2H2 Zn finger	490..506	CDD:275368	4/15 (27%)
Zfp160	NP_663458.2	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	148..168	CDD:275368	6/23 (26%)
		C2H2 Zn finger	176..196	CDD:275368	5/20 (25%)
		zf-H2C2_2	188..213	CDD:290200	6/39 (15%)
		COG5048	200..635	CDD:227381	103/501 (21%)
		zf-C2H2	202..224	CDD:278523	4/21 (19%)
		C2H2 Zn finger	204..224	CDD:275368	2/19 (11%)
		zf-H2C2_2	216..240	CDD:290200	5/23 (22%)
		C2H2 Zn finger	232..252	CDD:275368	6/27 (22%)
		zf-H2C2_2	244..269	CDD:290200	8/60 (13%)
		C2H2 Zn finger	260..280	CDD:275368	4/19 (21%)
		zf-H2C2_2	272..297	CDD:290200	4/24 (17%)
		C2H2 Zn finger	288..308	CDD:275368	3/19 (16%)
		zf-H2C2_2	300..325	CDD:290200	8/29 (28%)
		C2H2 Zn finger	316..336	CDD:275368	7/20 (35%)
		C2H2 Zn finger	344..364	CDD:275368	6/20 (30%)
		zf-H2C2_2	356..381	CDD:290200	9/25 (36%)
		C2H2 Zn finger	372..392	CDD:275368	5/19 (26%)
		zf-H2C2_2	384..409	CDD:290200	3/24 (13%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		zf-H2C2_2	412..436	CDD:290200	6/33 (18%)
		C2H2 Zn finger	428..448	CDD:275368	5/20 (25%)
		zf-H2C2_2	440..465	CDD:290200	7/30 (23%)
		C2H2 Zn finger	456..476	CDD:275368	7/24 (29%)
		zf-H2C2_2	468..493	CDD:290200	5/24 (21%)
		C2H2 Zn finger	484..504	CDD:275368	5/27 (19%)
		zf-H2C2_2	496..521	CDD:290200	4/32 (13%)
		C2H2 Zn finger	512..532	CDD:275368	3/19 (16%)
		zf-H2C2_2	524..548	CDD:290200	5/23 (22%)
		C2H2 Zn finger	540..560	CDD:275368	2/19 (11%)
		zf-H2C2_2	552..577	CDD:290200	6/27 (22%)
		C2H2 Zn finger	568..588	CDD:275368	5/19 (26%)
		zf-H2C2_2	580..604	CDD:290200	6/23 (26%)
		C2H2 Zn finger	596..616	CDD:275368	5/17 (29%)
		zf-H2C2_2	608..633	CDD:290200	2/5 (40%)
		C2H2 Zn finger	624..644	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832274
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930