DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8089 and zfx

DIOPT Version :9

Sequence 1:	NP_611014.1	Gene:	CG8089 / 36679	FlyBaseID:	FBgn0033993	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	XP_002935227.1	Gene:	zfx / 100038167	XenbaseID:	XB-GENE-479751	Length:	793	Species:	Xenopus tropicalis

Alignment Length:	389	Identity:	85/389 - (21%)
Similarity:	145/389 - (37%)	Gaps:	70/389 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 CYKCENLPWKKLQDVEDHQKTHRYS-------DNFHCQICYRRFYLQHSLTSHIIRKSTSSRELH 228
            |..|:....||: .:.:|.::|:.:       .:..|:.|.:.|...::|.:|    ..:.:|..
Frog   443 CTDCDYTTNKKV-SLHNHLESHKLTAAVIKTEKDLECEECGKIFLHANALFAH----KLTHKEKA 502

  Fly   229 ENKRYKRLLENQKSQEEKELELSLNKVEDILVP-VAEDLQSYFKDESKHPIQKRK---TSSLSK- 288
            .||.::....:.::.|:..|...|..|.....| :..:....|    :||.:.:|   |.:..|
Frog   503 GNKMHRCKFCDYETAEQGLLNRHLLAVHSKSFPHICVECGKGF----RHPSELKKHMRTHTGEKP 563

  Fly   289 --CPSCAQNYGFSFSHQLHM-VKHRRERLYTNFPFHCSFCNRSFLTRKFLRKHQQRVRTFSTLLY 350
              |..|......|.:.:.|: .||.:|     .||.|..|.::|...|.|:.|        .:|:
Frog   564 YLCQYCDYRSADSSNLKTHVKTKHSKE-----MPFKCDICLQTFADSKDLQAH--------AILH 615

  Fly   351 RPFK---CPHCTWRFQLKSALDSHVLRIHERRKPCLICKLPTSRLCCSAHTSKECNRAMQKYRDK 412
            :..|   |.||..:....|.|..|::.:|.:..|               |..:.|.:...: ..:
Frog   616 QESKSHQCLHCDHKSSNSSDLKRHIISVHTKDYP---------------HKCEVCEKGFHR-PSE 664

  Fly   413 MRPLREPPKGGCRKQPTPVCKICNRKFTRKFFLEEHMNKAHLNKRNFTCEICGANFYSQGTMQTH 477
            ::......||....|    |:.|..:....|.|..|:...|..:..|.|:.|...|..|..::.|
Frog   665 LKKHEAAHKGKKMHQ----CRHCEFQIADPFVLSRHILSVHTKELPFRCKRCKKGFRQQMELKKH 725

  Fly   478 RKAVHLLVHTVQCEVCDLTIKSKGNYRRHCKSQSHKDNLVKFGKNNDKTKDSNRRKGARTTDEK 541
            .| .|......|||.|:........::||..|...||    :....|..|     ||.|...||
Frog   726 MK-THSGKKVYQCEYCEYNTTDASGFKRHVISIHTKD----YPHRCDYCK-----KGFRRPSEK 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8089	NP_611014.1	C2H2 Zn finger	289..309	CDD:275368	4/20 (20%)
		C2H2 Zn finger	322..343	CDD:275368	6/20 (30%)
		C2H2 Zn finger	355..376	CDD:275368	6/20 (30%)
		C2H2 Zn finger	432..453	CDD:275368	5/20 (25%)
		C2H2 Zn finger	461..486	CDD:275368	7/24 (29%)
		C2H2 Zn finger	490..506	CDD:275368	3/15 (20%)
zfx	XP_002935227.1	Zfx_Zfy_act	71..395	CDD:368066
		zf-C2H2	410..432	CDD:333835
		C2H2 Zn finger	412..435	CDD:275368
		C2H2 Zn finger	443..463	CDD:275368	5/20 (25%)
		C2H2 Zn finger	478..498	CDD:275368	5/23 (22%)
		C2H2 Zn finger	509..530	CDD:275368	3/20 (15%)
		COG5048	534..>789	CDD:227381	67/293 (23%)
		C2H2 Zn finger	538..558	CDD:275368	4/23 (17%)
		C2H2 Zn finger	566..587	CDD:275368	4/20 (20%)
		C2H2 Zn finger	595..615	CDD:275368	6/27 (22%)
		C2H2 Zn finger	623..644	CDD:275368	6/20 (30%)
		C2H2 Zn finger	652..701	CDD:275368	9/53 (17%)
		C2H2 Zn finger	709..729	CDD:275368	6/20 (30%)
		C2H2 Zn finger	737..758	CDD:275368	6/20 (30%)
		C2H2 Zn finger	766..786	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24406
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100