DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment chn and ZNF518A

DIOPT Version :9

Sequence 1:	NP_001246331.1	Gene:	chn / 36678	FlyBaseID:	FBgn0015371	Length:	1286	Species:	Drosophila melanogaster
Sequence 2:	NP_001265453.1	Gene:	ZNF518A / 9849	HGNCID:	29009	Length:	1483	Species:	Homo sapiens

Alignment Length:	1014	Identity:	195/1014 - (19%)
Similarity:	324/1014 - (31%)	Gaps:	325/1014 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   472 SGSHGGNGNGGSGSGLLKPKREKRFTCCYCPWSGAD---------------------------KW 509
            :.:|..|||               |.|..|.:|..|                           |.
Human   198 TSTHCVNGN---------------FQCEKCKFSTQDVGTFVQHIHRHNEIHYKCGKCHHVCFTKG 247

  Fly   510 GLKRHLNTH--TKPFVCLLCDYKAARSERLATHVLKVHNKRACSKCSYLAD-------------- 558
            .|::||:.|  |.||.|..|.|.|.|.|.|..||:.:|.:...:|.....|
Human   248 ELQKHLHIHSGTFPFTCQYCSYGATRREHLVRHVITLHKEHLYAKEKLEKDKYEKRMAKTSAGLK 312

  Fly   559 -------------------------------------------TQEEYQAHMSDVHPHDNRPAR- 579
                                                       |:.|.|:|:...|..:.:..|
Human   313 LILKRYKIGASRKTFWKRKKINSGSDRSIEKNTQVLKKMNKTQTKSEDQSHVVQEHLSEEKDERL 377

  Fly   580 -SGNGNQSGGSSSGNSNGNGGGNGN---NNANAGGHSQNLNVL-RTIGNSLVANNQL-------N 632
             ..|.:::..|.|........|.||   ...||........|| .|:.|.::.||:|       .
Human   378 HCENNDKAPESESEKPTPLSTGQGNRAEEGPNASSGFMKTAVLGPTLKNVMMKNNKLAVSPNYNA 442

  Fly   633 TYAGNAF---------------------GSSSGNV--GNAN------GGGGAVTIYTTTTNEGVA 668
            |:.|...                     ||.||..  |.||      ...|.:|..||..|:.|.
Human   443 TFMGFKMMDGKQHIVLKLVPIKQNVCSPGSQSGAAKDGTANLQPQTLDTNGFLTGVTTELNDTVY 507

  Fly   669 GGGGGGGGGISGNISGGGPLQE---IIVNPSSM---VGWRLSANGSLIPPHDLLTGGLPNAATQK 727
            ..........|..:||....::   :|...::|   :.:..|.: ||....:|:|..: |..|:.
Human   508 MKAATPFSCSSSILSGKASSEKEMTLISQRNNMLQTMDYEKSVS-SLSATSELVTASV-NLTTKF 570

  Fly   728 RGSERL-FQYLEAEGSDPEDYARLL----KMDAISRNTASVAQDFHK---AGGVHELKIPANHQ- 783
            ...:.: |.......|.||.....:    |::.:::..|..:.|.|.   ..|..||.:.:::|
Human   571 ETRDNVDFWGNHLTQSHPEVLGTTIKSPDKVNCVAKPNAYNSGDMHNYCINYGNCELPVESSNQG 635

  Fly   784 -LLFNNKLP---SQWTTREAAALLYSLSNMGGGSASSVSGSQR---QKFGMRARQHSTGED---- 837
             |.|:|...   |....|.:...:|  .|....|:||.:..|:   :.|....||.|:..|
Human   636 SLPFHNYSKVNNSNKRRRFSGTAVY--ENPQRESSSSKTVVQQPISESFLSLVRQESSKPDSLLA 698

  Fly   838 ------DENTPSSASS-----------SSFSGDEFNMSATSPLKLSRHAIKLEKMDEMDAKDMGP 885
                  |::....|.|           .:..|.....:....|:.:....|.|....:|:..|..
Human   699 SISLLNDKDGTLKAKSEIEEQYVLEKGQNIDGQNLYSNENQNLECATEKSKWEDFSNVDSPMMPR 763

  Fly   886 TKAMMATAFLEAANYEQTAI-ELLASKRKIKVENDNDEDQENQQHQPHQQHHSQQQQQQRLQLIK 949
            ..::.:....:|:.:....: :||....|||.:...|......:..|.....|.|:.::..::::
Human   764 ITSVFSLQSQQASEFLPPEVNQLLQDVLKIKPDVKQDSSNTPNKGLPLHCDQSFQKHEREGKIVE 828

  Fly   950 SSPAYKLNN-----------NNNNNSNNNNYYKDKTSHRNAVHHHRQDDKENNKTKSPGTAAVSV 1003
            ||..:|:..           |...|..|..:.|:|     .|....||.:::.|.
Human   829 SSKDFKVQGIFPVPPGSVGINVPTNDLNLKFGKEK-----QVSSIPQDVRDSEKM---------- 878

  Fly  1004 AAAAATSPPSISGPSNQTPFLTQMEYQNLNRIGTQFQNYVKD-------IINKYYAAETPLMLAA 1061
                    |.|||      |.|.::.|: :.|.|  |..|||       .:..:| .::||:.:.
Human   879 --------PRISG------FGTLLKTQS-DAIIT--QQLVKDKLRATTQNLGSFY-MQSPLLNSE 925

  Fly  1062 AAAALPTATTTG------QQQQPELDIENLSPSKRRRLL-SETEEYIEYLRNKEDITLTI----- 1114
            ....:...|:.|      ...:|.|.:   .|.....|: |:......::..|..:.||:
Human   926 QKKTIIVQTSKGFLIPLNITNKPGLPV---IPGNALPLVNSQGIPASLFVNKKPGMVLTLNNGKL 987

  Fly  1115 ----------AP---------------KVQP------PAPVTSL-----LKRQLDLSTPRRSPKK 1143
                      ||               ||:|      |...:|:     :|...:.:.|.:.|..
Human   988 EGVSAVKTEGAPARGTVTKEPCKTPILKVEPNNNCLTPGLCSSIGSCLSMKSSSENTLPLKGPYI 1052

  Fly  1144 AAPAHS-------NSASNASRKSLN---------------QLATLLP-------LLADAASQQEY 1179
            ..|..|       |..|......||               .|.|.||       |.....::.|.
Human  1053 LKPTSSVKAVLIPNMLSEQQSTKLNISDSVKQQNEIFPKPPLYTFLPDGKQAVFLKCVMPNKTEL 1117

  Fly  1180 LAAPLDFSKKSSSRKQAQPKKIRLTPEAVVTLLRDKYLN 1218
            |...|   .::|:.:..||||...||:.::..:.:..||
Human  1118 LKPKL---VQNSTYQNIQPKKPEGTPQRILLKIFNPVLN 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chn	NP_001246331.1	C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	335..356	CDD:275368
		C2H2 Zn finger	498..518	CDD:275368	8/46 (17%)
		C2H2 Zn finger	524..545	CDD:275368	9/20 (45%)
ZNF518A	NP_001265453.1	C2H2 Zn finger	179..201	CDD:275368	0/2 (0%)
		C2H2 Zn finger	209..229	CDD:275368	4/19 (21%)
		C2H2 Zn finger	236..256	CDD:275368	4/19 (21%)
		C2H2 Zn finger	264..281	CDD:275368	7/16 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..415		14/64 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1164..1188
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24392
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100