DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chn and rest

DIOPT Version :9

Sequence 1:	NP_001246331.1	Gene:	chn / 36678	FlyBaseID:	FBgn0015371	Length:	1286	Species:	Drosophila melanogaster
Sequence 2:	XP_031759548.1	Gene:	rest / 734016	XenbaseID:	XB-GENE-955466	Length:	1453	Species:	Xenopus tropicalis

Alignment Length:	1032	Identity:	180/1032 - (17%)
Similarity:	299/1032 - (28%)	Gaps:	384/1032 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 LVAAAAAEPQLVQWTS---GGKLQSYAHVNQQQQQQQQPHQSTPKSKKHRQEHAAELIYASPST- 249
            |..|..|.|:|:...:   .|:|.| ...:...:.::|..:.|..:.....:...|.:..|||.
Frog    86 LSKADMAAPRLIMLANVALTGELSS-GCCDYTLEGERQMAELTTVNDNSFSDSEGERLEDSPSNA 149

  Fly   250 --SANAAQNLAQSTPTSAPSNSSGGSTSSSGGGGGRKKAAQAAAAAAAANGVHIQKRYACTHCPY 312
              |.|....:..:..:...:..:.|:..||......:|..:|.:.....|.....|.:.|..|.|
Frog   150 IQSPNFTMEMEPAERSKEGTYENDGTLLSSTLEVVAQKDNEAPSTTEDKNKCIKSKPFRCKPCQY 214

  Fly   313 STDRRDLYTRHENIH-------KDEK--------------------PFQCYACLKQFNRADHVKK 350
            ..:..:.:..|..||       .|.|                    |.||..|....||.||...
Frog   215 KAESEEEFVHHIKIHSAKIYTDNDNKKTQGKESDSNIPEESDISKGPIQCDRCGYNTNRFDHYLA 279

  Fly   351 HFLRMHRELQYDINKTRRHVSAGSGSSGSGSSGSGSHHSGGRGNVTINSAGVNIDNAFLEA--QR 413
            |.                                 .||:....|..:....:.......|.  ::
Frog   280 HL---------------------------------KHHNKAGENERVYKCTICTYTTVSEYHWKK 311

  Fly   414 HPTSSSMSIVETIEAVASATDMPLAQLKQEKMDDGAGVVLPLHVGVMQQPVASSSSGSSGSHGGN 478
            |..:....|:.|....:..:|.....::.          :..|.|
Frog   312 HLRNHYPRILYTCSQCSYFSDRKNNYIQH----------IRTHTG-------------------- 346

  Fly   479 GNGGSGSGLLKPKREKRFTCCYCPWSGADKWGLKRHLNTHT--KPFVCLLCDYKAARSERLATHV 541
                          |:.:.|..||:|.:.|..|.||:.||:  |||.|..|.|.|:....:..|.
Frog   347 --------------ERPYQCIICPYSSSQKTHLTRHMRTHSGEKPFKCEQCSYVASNQHEVTRHA 397

  Fly   542 LKVHN---KRACSKCSYLADTQEEYQAHMS-DVHPH-------DNRPARSGNGNQSGGSSSGNSN 595
            .:|||   ...|..|.|....:..::.|:. .|:|.       |...::..|......|.
Frog   398 RQVHNGPKPLTCPHCDYKTADRSNFKKHVELHVNPRQFLCPVCDYAASKKCNLQYHIKSR----- 457

  Fly   596 GNGGGNGNNNANAGGHSQNLNVLRTIGNSLVANNQLNTYAGNAFGSSSGNVGNANGGGGAVTIYT 660
                           ||...|:...     |:..:|.|        ..|.||.|:
Frog   458 ---------------HSGCTNITMD-----VSKVKLRT--------KKGEVGVAD---------- 484

  Fly   661 TTTNEGVAGGGGGGGGGISGNISGGGPLQEIIVNPSSMVGWRLSANGSLIPPHDLLTGGLPNAAT 725
            |.||                                     :.:.||::|
Frog   485 TDTN-------------------------------------KQTENGNII--------------- 497

  Fly   726 QKRGSERLFQYLEAEGSD--PEDYARLLKMDAISRNTASVAQDFHKAGGVHELKIPANHQLLFNN 788
                .::|.:.::||..:  .:...|::......::..|..|...||..|...||         .
Frog   498 ----KKKLEETVKAEKKERCVKSKKRMIDGQVAKKSRLSSTQKKIKASEVRAEKI---------E 549

  Fly   789 KLPSQWTTREAAALLYSLSN----------MGGGSASSVSGSQ-------RQKFGMRARQHSTGE 836
            |.......:..|.||.:.|:          :....||.|..|:       :.|..::.:::|..:
Frog   550 KFRKSSCVKRKADLLENPSDTLTSTVKKKKLKNSPASKVITSEIKDDIPKKVKGLVKKKENSAVK 614

  Fly   837 DDENTPSSASSSSFSGDEFNMSATSPLKLSRHAIKLEKMDEMDAK-DMGPTKAMMATAFLEAANY 900
            ......:.|.||       |.....|.|::..  |::|.:::|:| .:.|.        :|
Frog   615 SKHKKKTGAQSS-------NGKRNMPKKITEQ--KVDKGNKLDSKIPVAPD--------IE---- 658

  Fly   901 EQTAIELLASKRKIKVENDNDEDQENQQHQPHQQHHSQQQQQQRLQLIKSSPAYKLNNNNNNNSN 965
            ||..:.        ||.|:||.:                      |.:.:..|          |.
Frog   659 EQMIVG--------KVANENDSE----------------------QFVATDIA----------SI 683

  Fly   966 NNNYYKDKTSHRNAVHHHRQDDKENNKTKSPGTAAVSVAAAAATSPPSI---------SGPSNQT 1021
            |||...:.....|.|.|   .|...|.|.....:|.|.:.:...|...|         :|.|.|.
Frog   684 NNNLSTESCGLLNEVVH---TDLSINTTLETKLSAGSESKSEHVSKAIIELAMQVDVKAGISKQE 745

  Fly  1022 PFLTQMEYQNLNRIGTQFQNYVKDIINKYYAAETPLMLAAAAAALPTATTTGQQQQPELDIENLS 1086
            .              || .||:.||       ||              .:|..::..::.::|..
Frog   746 K--------------TQ-DNYLMDI-------ET--------------ISTDLEKPNQVLLQNGI 774

  Fly  1087 PSKRRR----LLSETEEYIEYLRNKEDITLTIAPKVQPPAPVTSLLKRQLDLSTPRR 1139
            |.|:..    ||.::.:...||              |...|.:.|||   |...|.:
Frog   775 PPKKGNTIADLLVDSAKTTVYL--------------QISKPTSCLLK---DCCQPNK 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chn	NP_001246331.1	C2H2 Zn finger	307..327	CDD:275368	4/19 (21%)
		C2H2 Zn finger	335..356	CDD:275368	7/20 (35%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		C2H2 Zn finger	524..545	CDD:275368	5/20 (25%)
rest	XP_031759548.1	zf-H2C2_5	322..346	CDD:404746	3/33 (9%)
		C2H2 Zn finger	324..344	CDD:275368	1/29 (3%)
		zf-H2C2_2	336..361	CDD:404364	7/68 (10%)
		C2H2 Zn finger	352..372	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..389	CDD:404364	12/24 (50%)
		C2H2 Zn finger	380..398	CDD:275368	5/17 (29%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		zf-H2C2_5	409..429	CDD:404746	4/19 (21%)
		C2H2 Zn finger	437..458	CDD:275368	3/40 (8%)
		PTZ00121	<498..>639	CDD:173412	28/156 (18%)
		PHA03307	850..>1185	CDD:223039
		FAP	952..>1026	CDD:399866
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24392
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100