DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment chn and RBAK

DIOPT Version :9

Sequence 1:	NP_001246331.1	Gene:	chn / 36678	FlyBaseID:	FBgn0015371	Length:	1286	Species:	Drosophila melanogaster
Sequence 2:	NP_001191385.1	Gene:	RBAK / 57786	HGNCID:	17680	Length:	714	Species:	Homo sapiens

Alignment Length:	461	Identity:	91/461 - (19%)
Similarity:	144/461 - (31%)	Gaps:	149/461 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 VNQQQQQQQQPHQSTPKSK---------KHRQEHAAELIYASPSTSANAAQNLAQSTPTSA---- 265
            |:::...:::|::.....|         :|.:.|:.|    .|...:...:...|.|..:.
Human   306 VHRRSHLEEKPYKCNECGKTFCQKLHLTQHLRTHSGE----KPYECSECGKTFCQKTHLTLHQRN 366

  Fly   266 -------PSNSSGGSTSSSGGGGGRKKAAQAAAAAAAANGVHI-QKRYACTHCPYSTDRRDLYTR 322
                   |.|..|.|.|       ||      :|.:.....|. :|.|.|..|..|..|:.....
Human   367 HSGERPYPCNECGKSFS-------RK------SALSDHQRTHTGEKLYKCNECGKSYYRKSTLIT 418

  Fly   323 HENIHKDEKPFQCYACLKQFNRADHVKKHFLRMHRELQYDINKTRRHVSAGSGSSGSGSSGSGSH 387
            |:..|..|||:||..|.|.|:|..::..|:.....|..|:.|:..:
Human   419 HQRTHTGEKPYQCSECGKFFSRVSYLTIHYRSHLEEKPYECNECGK------------------- 464

  Fly   388 HSGGRGNVTINSAGVNIDNAFLEAQRHPTSSSMSIVETIEAVASATDMPLAQLKQEKMD------ 446
                  ...:|||.:.......|.:.|..|......:..     .||...|.|:::..:
Human   465 ------TFNLNSAFIRHRKVHTEEKSHECSECGKFSQLY-----LTDHHTAHLEEKPYECNECGK 518

  Fly   447 --------DGAGVVLPLHVGVM--------------------------QQPVASSSSGSSGSHGG 477
                    ||.   .||..|..                          ::|...|..|.:.||
Human   519 TFLVNSAFDGH---QPLPKGEKSYECNVCGKLFNELSYYTEHYRSHSEEKPYGCSECGKTFSH-- 578

  Fly   478 NGNGGSGSGLLKPKR----EKRFTCCYCPWSGADKWGLKRHLNTHT--KPFVCLLCDYKAARSER 536
                  .|.|.:.:|    ||.:.|..|....:.|..|..|...|:  ||:.|..|....:|...
Human   579 ------NSSLFRHQRVHTGEKPYECYECGKFFSQKSYLTIHHRIHSGEKPYECSKCGKVFSRMSN 637

  Fly   537 LATHVLKVHNKR--ACSKC-------SYLA------DTQEEYQA--------HMSDVHPHDNRPA 578
            |..|......::  .|::|       |||.      ..::.|:.        |.|..:.| .|..
Human   638 LTVHYRSHSGEKPYECNECGKVFSQKSYLTVHYRTHSGEKPYECNECGKKFHHRSAFNSH-QRIH 701

  Fly   579 RSGNGN 584
            |.||.|
Human   702 RRGNMN 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chn	NP_001246331.1	C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..356	CDD:275368	6/20 (30%)
		C2H2 Zn finger	498..518	CDD:275368	5/19 (26%)
		C2H2 Zn finger	524..545	CDD:275368	5/20 (25%)
RBAK	NP_001191385.1	KRAB	8..68	CDD:214630
		C2H2 Zn finger	165..199	CDD:275368
		Required for interaction with RB1. /evidence=ECO:0000269\|PubMed:10702291	171..260
		C2H2 Zn finger	207..227	CDD:275368
		C2H2 Zn finger	263..283	CDD:275368
		C2H2 Zn finger	291..311	CDD:275368	1/4 (25%)
		C2H2 Zn finger	319..339	CDD:275368	2/19 (11%)
		COG5048	343..701	CDD:227381	81/412 (20%)
		C2H2 Zn finger	347..367	CDD:275368	2/19 (11%)
		C2H2 Zn finger	375..395	CDD:275368	7/32 (22%)
		C2H2 Zn finger	403..423	CDD:275368	5/19 (26%)
		Interaction with AR. /evidence=ECO:0000269\|PubMed:14664718	417..714		67/333 (20%)
		C2H2 Zn finger	431..451	CDD:275368	6/19 (32%)
		C2H2 Zn finger	459..479	CDD:275368	4/44 (9%)
		C2H2 Zn finger	513..533	CDD:275368	3/22 (14%)
		C2H2 Zn finger	541..561	CDD:275368	0/19 (0%)
		C2H2 Zn finger	569..589	CDD:275368	7/27 (26%)
		C2H2 Zn finger	597..617	CDD:275368	5/19 (26%)
		C2H2 Zn finger	625..645	CDD:275368	5/19 (26%)
		C2H2 Zn finger	653..673	CDD:275368	5/19 (26%)
		C2H2 Zn finger	681..701	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24392
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100