DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment chn and Zfp518b

DIOPT Version :9

Sequence 1:	NP_001246331.1	Gene:	chn / 36678	FlyBaseID:	FBgn0015371	Length:	1286	Species:	Drosophila melanogaster
Sequence 2:	NP_001074613.2	Gene:	Zfp518b / 100515	MGIID:	2140750	Length:	1082	Species:	Mus musculus

Alignment Length:	1003	Identity:	187/1003 - (18%)
Similarity:	306/1003 - (30%)	Gaps:	347/1003 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   493 EKRFTCCYCPWSGADKWGLKRHLNTHTK--PFVCLLCDYKAARSERLATHVLKVHNKRACSKCSY 555
            |.||.|.:|.:....|...:|||..||.  |:.|..|||.|.|::.:..|..:|| :||.:|..:
Mouse   162 EIRFICSHCSYISYTKGEFQRHLVKHTGIFPYRCEYCDYGAIRNDYIVKHRRRVH-ERAGAKRPF 225

  Fly   556 ---------------------------------LADTQEEYQAHMSDVHPHD------------- 574
                                             |:|....:..|.:....|:
Mouse   226 KTVAKLEPKRTSIPKQSMELSKGPSPRAAFQNKLSDQLSRFSLHANKDKTHNLMLLPELKKYQKD 290

  Fly   575 -----NRPARS--------GNGNQSGGSSSGNSNGNGGG-------------------------- 600
                 |:...|        ||.|......|.:......|
Mouse   291 VVCIPNKVTLSEPREVSLLGNKNVEVEVLSPSKEPVHPGMPLTVMAPSELVVPTNCLAQLMDVKV 355

  Fly   601 -NGNNNANAGGHSQNLNVLRTIGNSLVANNQLNTYAGNAFGSSSGNVGNANGGGGAVTIYTTTTN 664
             ||         :|.| ||:..  .|..|.:|.|..|:  |.:|..:....|.||...:.:...:
Mouse   356 VNG---------AQQL-VLKLF--PLEENARLETSRGD--GGTSECLSTEKGSGGQKKMLSPEAS 406

  Fly   665 EGVAGGGGGGGGGISGNISGGGPLQEIIVNPSSMVGWRLSANGSLIPPHDLLTGGLPNAATQKRG 729
            ..:|..|.      :|:..|...|..::......|.|..|.|..           :||:....:.
Mouse   407 RSLAVEGN------AGDFVGLDRLHSLVQKQLKNVKWVKSCNFF-----------MPNSGVHSQQ 454

  Fly   730 SERLFQYLEAEGSDPEDYARLLKMDAISRNTASVAQDFHKAGGVHELKIPANHQLLFNNKLPSQW 794
            ...|       |||.                            :.||:  .:|.|.....|||..
Mouse   455 ESFL-------GSDT----------------------------IKELQ--KSHSLCPPRALPSAA 482

  Fly   795 TTREAAALLYSLSNMGGGSASSVSGSQRQKFGMRARQHSTGEDDENTP--SSASSSSFSGD---- 853
            ....:.|.:.:....|.|:..|...|:........|:.:.....:..|  |..|...|||:
Mouse   483 IKSHSPASVQNSVPYGPGATVSHFLSKAAVAFADDRRGARSNSQQLLPLASLPSKVPFSGEKGLL 547

  Fly   854 ---EFNMSA----TSPLKLSRHAIKLEKMDEMDAKDMGPTKAMMATAFLEAANYEQTAIELLASK 911
               |.::.|    :.|..|.....|||. .:|::|.:|.|                ..:..:.:|
Mouse   548 PIGESDLEARNRISRPETLVSSDRKLED-KQMESKAVGNT----------------GQVSSVQNK 595

  Fly   912 RKIKVENDNDEDQENQQ--HQPHQQHHSQQQQQQRLQLIKSSPAYKLNNNNNN-------NSNNN 967
            ..:.:....::...:||  .||.|...|:.........|.|| .:.|::.:.|       ||:..
Mouse   596 EYLHINITGEDKPRSQQPGDQPGQPKTSETAGATFEGPIISS-VFSLSSGSENVPEAIKWNSSTT 659

  Fly   968 NYYK---------------DKTSHRNAVHHHRQDDKENNKTKSPGT------AAVSVAAAAATSP 1011
            ....               .|.|..:|....|:...:..|..|..|      .:||:.....|..
Mouse   660 KIKSIELLRRKIAQLIESCGKPSSLSANSAQRRSIGQAPKLTSKATPKAIQEMSVSLTGPGPTPG 724

  Fly  1012 PSISGPSNQTP-------------------FLTQMEYQNLNRIGTQF---------QNYVKDIIN 1048
            ||: ||..:.|                   |::..:.:..||:..:.         :..|..::|
Mouse   725 PSV-GPLQKPPNEDSITGSRQLVPQQVCPQFISANDGKMENRVTRKTPVATPVLIPKGAVLRVLN 788

  Fly  1049 KYYAA-------ETPLML----AAAAAALP--TATTTGQQQQP---ELDIENLSPSKRRRLLSET 1097
            ....|       :||:.:    |..|..||  ....||...||   .....::||.....|..::
Mouse   789 SSEDAHIIEATCDTPVSIPCSEAQLAGTLPFCPMKQTGSGSQPLTCRSGPADMSPGLETSLRPKS 853

  Fly  1098 EEYIEYLRNKEDITLTIAPKVQP---PAPVTS-------LLKRQLDLSTPRRSPKKAAPAHSNSA 1152
                   |.::.|....|.|:.|   .||.:|       .:.|.|.:|..:.....:....:...
Mouse   854 -------RKEDTICSATAKKMVPVYSTAPGSSDSIRQGRPVSRNLTVSKNKTKQVNSTKKKNKMQ 911

  Fly  1153 SNASR-----KSLNQLATLLPLLADAASQQEYLAAPLDFSKKSSSRKQAQPKKIRLTPEA----V 1208
            :|..|     .|..|:|..|.|:  ||...:.:..|          ::.||..:...|:.    |
Mouse   912 ANPGRYFKDPPSFFQVARQLRLI--AAKPDQLIKCP----------RRNQPVIVLNHPDVDSPEV 964

  Fly  1209 VTLLR--DKY---------------------------------LNRMVRQRLGCLKCNQLRKNSS 1238
            ..:::  :||                                 .|.|.||.:..:|..::.||
Mouse   965 TNVMKVINKYKGNVLKVVLSERTRCQLGVRRYHMRLTYQNVAETNHMKRQMMLKMKLKKVHKN-- 1027

  Fly  1239 ISFNYHTLGSL------ALHKYWRHGRL 1260
               ||..:||:      .:.|.|..|||
Mouse  1028 ---NYQVVGSMPDDPAQCVFKCWFCGRL 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chn	NP_001246331.1	C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	335..356	CDD:275368
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		C2H2 Zn finger	524..545	CDD:275368	7/20 (35%)
Zfp518b	NP_001074613.2	C2H2 Zn finger	140..160	CDD:275368
		zf-H2C2_5	167..189	CDD:372805	7/21 (33%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		C2H2 Zn finger	195..216	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24392
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100