DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7639 and samm50l

DIOPT Version :9

Sequence 1:	NP_995838.1	Gene:	CG7639 / 36675	FlyBaseID:	FBgn0033989	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001007344.1	Gene:	samm50l / 492471	ZFINID:	ZDB-GENE-041114-30	Length:	469	Species:	Danio rerio

Alignment Length:	469	Identity:	158/469 - (33%)
Similarity:	233/469 - (49%)	Gaps:	39/469 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PKSGRDGGASKDSKYDLSKISAR-----------VDRVNVSGLLRTHNDYVMRAADGLFKASNFQ 55
            |..|||.|.:.|....:..:...           |..||:.||.||..||:......:|.|.|..
Zfish    13 PMYGRDLGVNTDDMEVMEAVQETKQEVLENKDVVVQHVNIEGLGRTKEDYLGYEISDVFTARNLV 77

  Fly    56 DLMLEAMSTKSYLHELGIFKDVSVHIDVSRGADASPQGYEVTFKGNEMSRMMGSAGTEIGQNEGS 120
            ::|.::...:..|..||||:||.|.||:|.||||.|.|.:|||:..|:.|:.||..|.:|.||||
Zfish    78 EVMRKSHEARQRLLRLGIFRDVEVVIDISEGADALPNGLDVTFEVTELKRLTGSYNTMVGNNEGS 142

  Fly   121 LRTELTIPNILGRGENISLQGSYSSTRANDLQLKFWKP---FFHTRFKENRPEMSFSIFRQTDRF 182
            :...:.:||:|||||.::.|.|| .|:.....|.|:||   :|...|..|       :::.|.:|
Zfish   143 MVLGIKLPNMLGRGEKLTFQFSY-GTKETSYGLSFFKPQSGYFERNFTVN-------LYKVTGQF 199

  Fly   183 DISSFQTTNIGYLVDFSAHTMVGVDLTHSLQYENAIRDVGLLNKSVPFAIRDHCGPKLASLLRYS 247
            ..||.:.|:.|...:.|....:   ..|:|::|...|::|.|.:|..||:|:..|..|.|.|.::
Zfish   200 PWSSLKETDRGVSTELSLPLWM---TDHTLKWEGVWRELGCLARSASFAVREESGHTLKSALSHT 261

  Fly   248 VVYDNRDGNVFPTRGIYLKSVNEYCG-LGGNVAYTSSTAHGELNVPLFAGLVAQFCARVGVVKET 311
            :|.|.|:..:.|.:|..|:...|..| .||:..:.......:||.....|.|.......|::...
Zfish   262 MVVDTRNSAILPRKGALLRINQELAGYTGGDANFLKEDVELQLNKQFIWGSVLSASLWGGMIYPL 326

  Fly   312 KNTTQLPISSLFYCGGPLTLRGFKFGGAGPVVESTPIGAQSFWCTGAHLWAPLPFAGVFKNLASH 376
             ......|:..||.|||.::|||.....||..|...:|.:::|..|.||:.||||......||..
Zfish   327 -GAQPTSIADRFYLGGPTSVRGFGMYSIGPQSEGDYLGGEAYWAGGLHLYTPLPFRSNKGGLADL 390

  Fly   377 FRMHFFYNIGN--NNSFS----------TENMRSAFGMGLAVKLAERARIELNYCVPVRHQDTDR 429
            ||.|||.|.||  |.::.          .|.:|.::|.|:.::|...||:|||||.|:..|..||
Zfish   391 FRTHFFLNAGNICNLNYGEGPRAHLQKLAECIRWSYGAGIILRLGNIARLELNYCFPMGVQSGDR 455

  Fly   430 ILNGFQFGIGYEFV 443
            |.:|.|||.|..|:
Zfish   456 ICDGVQFGAGIRFL 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7639	NP_995838.1	Bac_surface_Ag	129..442	CDD:279448	107/328 (33%)
samm50l	NP_001007344.1	POTRA	45..124	CDD:284624	33/78 (42%)
samm50l	NP_001007344.1	Bac_surface_Ag	151..468	CDD:279448	107/328 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581928
Domainoid	1	1.000	165	1.000	Domainoid score	I3869
eggNOG	1	0.900	-	-		E1_COG4775
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133961
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3239
OMA	1	1.010	-	-		QHG56599
OrthoDB	1	1.010	-	-		D242907at33208
OrthoFinder	1	1.000	-	-		FOG0003150
OrthoInspector	1	1.000	-	-		otm25946
orthoMCL	1	0.900	-	-		OOG6_102372
Panther	1	1.100	-	-	O	PTHR12815
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1283
SonicParanoid	1	1.000	-	-		X4093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800