DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7639 and SAMM50

DIOPT Version :9

Sequence 1:	NP_995838.1	Gene:	CG7639 / 36675	FlyBaseID:	FBgn0033989	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_056195.3	Gene:	SAMM50 / 25813	HGNCID:	24276	Length:	469	Species:	Homo sapiens

Alignment Length:	477	Identity:	163/477 - (34%)
Similarity:	249/477 - (52%)	Gaps:	53/477 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPKSGRD-GGASKDSKYDLSKISAR----------VDRVNVSGLLRTHNDYVMRAADGLFKASNF 54
            :|.||.| ||..:::::...:..|:          |..|:..||.||.:|.::.....:|||.|.
Human    12 LPSSGPDFGGLGEEAEFVEVEPEAKQEILENKDVVVQHVHFDGLGRTKDDIIICEIGDVFKAKNL 76

  Fly    55 QDLMLEAMSTKSYLHELGIFKDVSVHIDVSRGADASPQGYEVTFKGNEMSRMMGSAGTEIGQNEG 119
            .::|.::...:..|..||||:.|.|.||..:|.||.|.|.:|||:..|:.|:.||..|.:|.|||
Human    77 IEVMRKSHEAREKLLRLGIFRQVDVLIDTCQGDDALPNGLDVTFEVTELRRLTGSYNTMVGNNEG 141

  Fly   120 SLRTELTIPNILGRGENISLQGSYSSTRANDLQLKFWKPFFHTRFKENRP---EMSFSI--FRQT 179
            |:...|.:||:|||.|.::.|.|| .|:.....|.|:||         ||   |.:||:  ::.|
Human   142 SMVLGLKLPNLLGRAEKVTFQFSY-GTKETSYGLSFFKP---------RPGNFERNFSVNLYKVT 196

  Fly   180 DRFDISSFQTTNIGYLVDFSAHTMVGVDLTHSLQYENAIRDVGLLNKSVPFAIRDHCGPKLASLL 244
            .:|..||.:.|:.|...::|....   ..:|::::|...|::|.|:::..||:|...|..|.|.|
Human   197 GQFPWSSLRETDRGMSAEYSFPIW---KTSHTVKWEGVWRELGCLSRTASFAVRKESGHSLKSSL 258

  Fly   245 RYSVVYDNRDGNVFPTRGIYLKSVNEYCG-LGGNVAYTSSTAHGELNVPLFAGLV--AQFCARVG 306
            .:::|.|:|:.::.|.||..||...|..| .||:|::.......:||..|....|  |.|...:.
Human   259 SHAMVIDSRNSSILPRRGALLKVNQELAGYTGGDVSFIKEDFELQLNKQLIFDSVFSASFWGGML 323

  Fly   307 VVKETKNTTQLPISSLFYCGGPLTLRGFKFGGAGPVVESTPIGAQSFWCTGAHLWAPLPF---AG 368
            |....|.::   |:..||.|||.::|||.....||..|...:|.:::|..|.||:.||||   .|
Human   324 VPIGDKPSS---IADRFYLGGPTSIRGFSMHSIGPQSEGDYLGGEAYWAGGLHLYTPLPFRPGQG 385

  Fly   369 VFKNLASHFRMHFFYNIGN--NNSFS----------TENMRSAFGMGLAVKLAERARIELNYCVP 421
            .|..|   ||.|||.|.||  |.::.          .|.:|.::|.|:.::|...||:|||||||
Human   386 GFGEL---FRTHFFLNAGNLCNLNYGEGPKAHIRKLAECIRWSYGAGIVLRLGNIARLELNYCVP 447

  Fly   422 VRHQDTDRILNGFQFGIGYEFV 443
            :..|..|||.:|.|||.|..|:
Human   448 MGVQTGDRICDGVQFGAGIRFL 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7639	NP_995838.1	Bac_surface_Ag	129..442	CDD:279448	114/335 (34%)
SAMM50	NP_056195.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		4/7 (57%)
		POTRA	45..124	CDD:284624	29/78 (37%)
		Bac_surface_Ag	151..468	CDD:279448	114/335 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148016
Domainoid	1	1.000	165	1.000	Domainoid score	I3922
eggNOG	1	0.900	-	-		E1_COG4775
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3351
Isobase	1	0.950	-	0	Normalized mean entropy	S3114
OMA	1	1.010	-	-		QHG56599
OrthoDB	1	1.010	-	-		D242907at33208
OrthoFinder	1	1.000	-	-		FOG0003150
OrthoInspector	1	1.000	-	-		oto91228
orthoMCL	1	0.900	-	-		OOG6_102372
Panther	1	1.100	-	-	LDO	PTHR12815
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1283
SonicParanoid	1	1.000	-	-		X4093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750