DRSC/TRiP Functional Genomics Resources

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Protein Alignment pcs and SH3BP5

DIOPT Version :9

Sequence 1:NP_611010.4 Gene:pcs / 36674 FlyBaseID:FBgn0033988 Length:477 Species:Drosophila melanogaster
Sequence 2:NP_004835.2 Gene:SH3BP5 / 9467 HGNCID:10827 Length:455 Species:Homo sapiens


Alignment Length:412 Identity:145/412 - (35%)
Similarity:212/412 - (51%) Gaps:82/412 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EDGELDPQIQIELENLNSATDEINKLEIELEEANSTFRILLNESTRRLKVSSKKLGNCIEKARPY 69
            |:.|:||:||.|||.||.:||:||:.|.|||:|...||.:|.|:|.:|....||:|..:|.::||
Human    37 EEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELVKKIGKAVEDSKPY 101

  Fly    70 YEALDKAREAQIECQKAAVKFQRANEIHAAAKETVALAEQRFMSNSHEWQFDNAWQEMLNHATQK 134
            :||...||:||:|.|||...||||.|:..|||||::|||||.:.:... |||:|||||||||||:
Human   102 WEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKR-QFDSAWQEMLNHATQR 165

  Fly   135 VMDAETQKADCHAEHQRLTKLFNAAEQKLQQLEDRFRRSINKSRPYFEEKQVCQDQLQTQKNRIQ 199
            ||:||..|......|:.....:|||..:::|||.:.:|:||||:||||.|.....||:..|..:.
Human   166 VMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVD 230

  Fly   200 ELQQQVAGAKSTYSTALRNLERISEDIHRQRGDFPTPPGPREPGVGAELNSPTSSALP------- 257
            :||.::..||..|..||:|||.||::||.:|..  :..|||..|||||.:|.:...||       
Human   231 DLQAKLTLAKGEYKMALKNLEMISDEIHERRRS--SAMGPRGCGVGAEGSSTSVEDLPGSKPEPD 293

  Fly   258 --SLPDFQLELEKC----------------------------------------DYPS-IAGSQM 279
              |:.....|.:.|                                        |.|| ::.|:.
Human   294 AISVASEAFEDDSCSNFVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEF 358

  Fly   280 SL------------GAKTPQAAAETEDEEDACDYDETG--AGELRGVVDER-------------- 316
            .:            ||.:|:...|..|..:..: ::|.  |...||:....              
Human   359 GMMFPVLGPRSECSGASSPECEVERGDRAEGAE-NKTSDKANNNRGLSSSSGSGGSSKSQSSTSP 422

  Fly   317 DLEALRQKVKILAVRPIEGGDG 338
            :.:||..::|.|:::..:|.||
Human   423 EGQALENRMKQLSLQCSKGRDG 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pcsNP_611010.4 SH3BP5 8..235 CDD:283045 110/226 (49%)
SH3BP5NP_004835.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63 15/25 (60%)
Sufficient for interaction with RAB11A and for guanine nucleotide exchange activity. /evidence=ECO:0000269|PubMed:30217979 31..265 111/230 (48%)
SH3BP5 41..269 CDD:310118 110/230 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..293 12/35 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 306..345 1/38 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 369..435 12/66 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151990
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2008
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0.917438 Normalized mean entropy S5575
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D258813at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_104684
Panther 1 1.100 - - LDO PTHR19423
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.660

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