DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pcs and SH3BP5L

DIOPT Version :9

Sequence 1:	NP_611010.4	Gene:	pcs / 36674	FlyBaseID:	FBgn0033988	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_085148.1	Gene:	SH3BP5L / 80851	HGNCID:	29360	Length:	393	Species:	Homo sapiens

Alignment Length:	367	Identity:	156/367 - (42%)
Similarity:	213/367 - (58%)	Gaps:	46/367 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSAEDGELDPQIQIELENLNSATDEINKLEIELEEANSTFRILLNESTRRLKVSSKKLGNCIEK 65
            :|..|:.||||:||.|||:||.|::|||::|::|:||.:|:|.:|.||.|:|......||:||||
Human    48 LSPREEEELDPRIQEELEHLNQASEEINQVELQLDEARTTYRRILQESARKLNTQGSHLGSCIEK 112

  Fly    66 ARPYYEALDKAREAQIECQKAAVKFQRANEIHAAAKETVALAEQRFMSNSHEWQFDNAWQEMLNH 130
            |||||||...|:|||.|.||||::::||..:|.||:|.|.:|||..|::.:  :.|..|||||||
Human   113 ARPYYEARRLAKEAQQETQKAALRYERAVSMHNAAREMVFVAEQGVMADKN--RLDPTWQEMLNH 175

  Fly   131 ATQKVMDAETQKADCHAEHQRLTKLFNAAEQKLQQLEDRFRRSINKSRPYFEEKQVCQDQLQTQK 195
            ||.||.:||.::.....||||:|:|...||.::|.|:...||:|.|||||||.|......|:..|
Human   176 ATCKVNEAEEERLRGEREHQRVTRLCQQAEARVQALQKTLRRAIGKSRPYFELKAQFSQILEEHK 240

  Fly   196 NRIQELQQQVAGAKSTYSTALRNLERISEDIH-RQRGDFPTPP-GPREPG-VGAELNSPTSSALP 257
            .::.||:||||.||:.||.||||||:|||.|| |:||..|..| |||... ||||..
Human   241 AKVTELEQQVAQAKTRYSVALRNLEQISEQIHARRRGGLPPHPLGPRRSSPVGAEAG-------- 297

  Fly   258 SLPDFQLELEKCDYPSIAGSQ-------MSLGAKTPQAAAETE-----------DEEDACDYDET 304
              |:   ::|..| ..|.|::       .|||   |..|.:|:           .:...||..|
Human   298 --PE---DMEDGD-SGIEGAEGAGLEEGSSLG---PGPAPDTDTLSLLSLRTVASDLQKCDSVE- 352

  Fly   305 GAGELRGVVDERDLEALRQKVKILAVRPIEGG--DGQQQNDV 344
               .|||:.|...|:......:....|..:||  .|:.|..|
Human   353 ---HLRGLSDHVSLDGQELGTRSGGRRGSDGGARGGRHQRSV 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pcs	NP_611010.4	SH3BP5	8..235	CDD:283045	120/227 (53%)
SH3BP5L	NP_085148.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		4/9 (44%)
		SH3BP5	55..283	CDD:310118	121/229 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..332		23/75 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..393		7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2524
eggNOG	1	0.900	-	-		E1_KOG2008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3375
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258813at33208
OrthoFinder	1	1.000	-	-		FOG0003963
OrthoInspector	1	1.000	-	-		oto89805
orthoMCL	1	0.900	-	-		OOG6_104684
Panther	1	1.100	-	-	O	PTHR19423
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3845
SonicParanoid	1	1.000	-	-		X5780
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.900