DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pcs and Sh3bp5

DIOPT Version :9

Sequence 1:	NP_611010.4	Gene:	pcs / 36674	FlyBaseID:	FBgn0033988	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_036024.2	Gene:	Sh3bp5 / 24056	MGIID:	1344391	Length:	458	Species:	Mus musculus

Alignment Length:	411	Identity:	147/411 - (35%)
Similarity:	212/411 - (51%)	Gaps:	80/411 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EDGELDPQIQIELENLNSATDEINKLEIELEEANSTFRILLNESTRRLKVSSKKLGNCIEKARPY 69
            |:.|:||:||.|||.||.:||:||:.|.|||:|...||.:|.|:|.:|...:||:|..:|.::||
Mouse    40 EEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELAKKIGKAVEDSKPY 104

  Fly    70 YEALDKAREAQIECQKAAVKFQRANEIHAAAKETVALAEQRFMSNSHEWQFDNAWQEMLNHATQK 134
            :||...||:||:|.|||...||||.|:..|||||::|||||.:.:... |||:|||||||||||:
Mouse   105 WEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKR-QFDSAWQEMLNHATQR 168

  Fly   135 VMDAETQKADCHAEHQRLTKLFNAAEQKLQQLEDRFRRSINKSRPYFEEKQVCQDQLQTQKNRIQ 199
            ||:||..|......|:.....:|||..:::|||.:.:|:||||:||||.|.....||:..|..:.
Mouse   169 VMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVD 233

  Fly   200 ELQQQVAGAKSTYSTALRNLERISEDIHRQRGDFPTPPGPREPGVGAE------LNSPTSSALP- 257
            :||.::|.||..|..||::|||||::||.:|..  ...|||..|||||      .|.|.|...|
Mouse   234 DLQAKLALAKGEYKAALKSLERISDEIHERRRS--NAMGPRGCGVGAEGSIASVENLPVSKPEPD 296

  Fly   258 --SLPDFQLELEKC-----------------------------DYPSIA-------GSQMSL--- 281
              |:.....|.:.|                             .:|::|       .|.:||
Mouse   297 AISVASEAFEDDNCSNLVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVARPGSLDLPSPVSLSEF 361

  Fly   282 --------------GAKTPQAAAETEDEEDACDYDET--------------GAGELRGVVD-ERD 317
                          ||.:|:...|..|..:..:...:              |:|..|.... ..:
Mouse   362 GMMFPILGPRSECSGASSPECEVERGDRAEGAENKMSDKANNNRVLGSTNGGSGRSRSQSSTSLE 426

  Fly   318 LEALRQKVKILAVRPIEGGDG 338
            .:||..::|.|:::..:|.||
Mouse   427 SQALETRMKQLSLQCSKGRDG 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pcs	NP_611010.4	SH3BP5	8..235	CDD:283045	111/226 (49%)
Sh3bp5	NP_036024.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..69		16/28 (57%)
		Sufficient for interaction with RAB11A and for guanine nucleotide exchange activity. /evidence=ECO:0000250\|UniProtKB:O60239	33..268		112/230 (49%)
		SH3BP5	44..270	CDD:283045	110/228 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..348		3/38 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..429		8/56 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842105
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S5575
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258813at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104684
Panther	1	1.100	-	-	LDO	PTHR19423
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.660