DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ckn and Sash1

DIOPT Version :9

Sequence 1:	NP_611009.1	Gene:	ckn / 36673	FlyBaseID:	FBgn0033987	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_030101115.1	Gene:	Sash1 / 70097	MGIID:	1917347	Length:	1392	Species:	Mus musculus

Alignment Length:	509	Identity:	100/509 - (19%)
Similarity:	161/509 - (31%)	Gaps:	188/509 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LRHHQNHQADDGISMSGSSIVSSPSLEEGGFNLPRETSVALRLKDEVGGTSTAAPTTGGPGGGGA 131
            ||.||                .|.:...|||:|   |:.:|.:     |::.:.|
Mouse   552 LRIHQ----------------KSRTCSFGGFDL---TNRSLHV-----GSNNSDP---------- 582

  Fly   132 TVVGAPPPGAGKPG------VAMVPPPPVF-----CATLREPLTHKAAVYYHQQLALQEDQGID- 184
                     |||.|      |...||.|..     ..:::|.:..:.:..|...:: ::|.|:|
Mouse   583 ---------AGKEGDFVYKEVIKSPPAPRISLGKKVRSVKETMRKRMSKKYSSPVS-EQDSGLDG 637

  Fly   185 LTQSPGRDSPGS------------------SSGSAGSGSRHSTASLDSGRASSYLTGVSSSGASI 231
            :..||....|.|                  ||.|..|.....|.|......|:..:..|..|...
Mouse   638 MPSSPASGKPDSEHVDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDE 702

  Fly   232 RAPLSSPRCS--------SVSSCSIGSVDRQRNDELIID---------W--LLEMKHEEYAQLFI 277
            ..|...|.|.        :.|.....|:..::.|  |||         |  ||..|...:..:::
Mouse   703 EPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGD--IIDIISKPPMGTWMGLLNNKVGTFKFIYV 765

  Fly   278 AAGYDLPTIARMTPEDLTAIGIKNPHHRERIKQRIDKLQVLDNLPHFVPGSIEEWLQLLRLEEYI 342
                |:.......|:..|         |.|.|.|..:           |.|:|:.|..:.|:|::
Mouse   766 ----DVLNEEEEKPKRPT---------RRRKKGRPSQ-----------PKSVEDLLDRINLKEHM 806

  Fly   343 QPLLEQNYKTVRDVTQVTWEDLEDIGIVKLGHQKKILLAIKRVKDIISGKWNPGGANAYQQQEYQ 407
            ...|...|:.:.....:..|||:::.|....|:..:|.|::.:                  |||.
Mouse   807 PTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELL------------------QEYD 853

  Fly   408 RKPWQFNVPIPSTPSYVPTTRVSWDDTKIYATSSVLNSTAPSGSSCLNSS--LANGDAYYCTGSN 470
            ....|                 |....|:...:..|:..:|..|.|..||  |.|.
Mouse   854 SNSDQ-----------------SGSQEKLLVDNQGLSGRSPRDSGCYESSENLENA--------- 892

  Fly   471 HECCSGNDVVLIKVRQPRGKSLESLEDIHDNSTRSHLTFSHYTTTDYGHFGPPT 524
                        |..:|...|.:|       ||.|:|  ..:|.:..|::  ||
Mouse   893 ------------KTHKPSVLSTKS-------STESNL--KSFTRSQPGNY--PT 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	15/75 (20%)
		SAM	260..316	CDD:197735	14/66 (21%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897	15/69 (22%)
		SAM	326..387	CDD:197735	15/60 (25%)
		Caskin-tail	<887..912	CDD:293238
Sash1	XP_030101115.1	SLY	559..710	CDD:372142	35/178 (20%)
		SH3_SASH1	712..768	CDD:212900	11/61 (18%)
		SAM_SASH1_repeat1	789..853	CDD:188958	17/92 (18%)
		PHA03307	855..>1214	CDD:223039	23/118 (19%)
		SAM_SASH1_repeat2	1318..1387	CDD:188891
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900