DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ckn and Inppl1

DIOPT Version :9

Sequence 1:	NP_611009.1	Gene:	ckn / 36673	FlyBaseID:	FBgn0033987	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_075233.1	Gene:	Inppl1 / 65038	RGDID:	68396	Length:	1257	Species:	Rattus norvegicus

Alignment Length:	293	Identity:	63/293 - (21%)
Similarity:	96/293 - (32%)	Gaps:	119/293 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 VSSPSLEEGGFNLPRETSVALRLKDEVGGTSTAAPTTGGPGGGGATVVGAPPPGAGKP------- 144
            ::.|:.:.|....||           ||..|::...:||.         .|||....|
  Rat  1020 ITVPAPQLGRHRTPR-----------VGEGSSSDEDSGGT---------LPPPDFPPPPLPDSAI 1064

  Fly   145 -------------------GVAMVPPPPVFCATLREPL---THKAAVYYHQQLALQEDQGIDLTQ 187
                               |.|..||||.  |..|.||   |..|:.:. :::|..:|:...:.|
  Rat  1065 FLPPNLDPLSMPVVRGRSVGEARGPPPPK--AHPRPPLPPGTSPASTFL-EEVASADDRSCSVLQ 1126

  Fly   188 ----------SPGRDSPGSSSGSAGSGSRHSTASLDSGRASSYLTGVSSSGASIRAPLSSP---- 238
                      |||   ||.|            |.|.:........|.|..|    .|||.|
  Rat  1127 MAKTLSEVDYSPG---PGRS------------ALLPNPLELQLPRGPSDYG----RPLSFPPPRI 1172

  Fly   239 ------------------RCSSVSSCSIGSVDRQRNDELIIDWLLEMKHEEYAQLFIAAGY-DLP 284
                              |.|.:....:|:            ||..:..|.|.:..:..|: ||.
  Rat  1173 RESIQEDLAEEAPCPQGGRASGLGEAGMGA------------WLRAIGLERYEEGLVHNGWDDLE 1225

  Fly   285 TIARMTPEDLTAIGIKNPHHRERIKQRIDKLQV 317
            .::.:|.|||...|:::|.|:..:   :|.||:
  Rat  1226 FLSDITEEDLEEAGVQDPAHKRLL---LDTLQL 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	17/65 (26%)
		SAM	260..316	CDD:197735	15/56 (27%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897
		SAM	326..387	CDD:197735
		Caskin-tail	<887..912	CDD:293238
Inppl1	NP_075233.1	SH2_SHIP	17..119	CDD:198206
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..181
		INPP5c_SHIP2-INPPL1	425..728	CDD:197335
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..986
		SH3-binding	945..950
		NPXY motif	984..987
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1115		25/117 (21%)
		SAM_Ship2	1193..1255	CDD:188890	18/76 (24%)
		SAM	1201..1257	CDD:197735	18/70 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810