DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ckn and SAMSN1

DIOPT Version :9

Sequence 1:	NP_611009.1	Gene:	ckn / 36673	FlyBaseID:	FBgn0033987	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001382787.1	Gene:	SAMSN1 / 64092	HGNCID:	10528	Length:	701	Species:	Homo sapiens

Alignment Length:	462	Identity:	97/462 - (20%)
Similarity:	161/462 - (34%)	Gaps:	132/462 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 HHPHHQPSIPLYRL-------SGPLRHHQNHQADDGISMSGSSIVSSPSLEEGGF-NLPRETSVA 106
            ||....|..||:..       .||..|..:......:..|.|.:....|.....| |..|..:.:
Human   298 HHWKPFPENPLWTCLDFQIAQVGPWDHCSSCIRHTRLKSSCSDMDLLHSWRSSSFGNFDRFRNNS 362

  Fly   107 LRLKDEVGGTSTAAPTTGG------PGGGGATVVGAPPPGAGKPGVAMVPPPPVFCATLREPLTH 165
            |...|:........||.|.      ...||         |.||...|:       ..|:::.:..
Human   363 LSKPDDSTEAHEGDPTNGSGEQSKTSNNGG---------GLGKKMRAI-------SWTMKKKVGK 411

  Fly   166 KAAVYYHQQLALQEDQGIDLTQSPGRDSP---GSSSGSAGSGSRHSTASLDSGRASSYLTGVS-- 225
            |    |.:.|:.::|:.......|.|:|.   |:.:......:..|..||.||::||  :|::
Human   412 K----YIKALSEEKDEEDGENAHPYRNSDPVIGTHTEKVSLKASDSMDSLYSGQSSS--SGITSC 470

  Fly   226 SSGASIR--------APLSSPRCS--------SVSSCSIGSVDRQRNDELIID---------W-- 263
            |.|.|.|        .|.|.|.|.        :.|.....|:..::.|  |||         |
Human   471 SDGTSNRDSFRLDDDGPYSGPFCGRARVHTDFTPSPYDTDSLKIKKGD--IIDIICKTPMGMWTG 533

  Fly   264 LLEMKHEEYAQLFIAAGYDLPTIARMTPEDLTAIGIKNPHHRERIKQRIDKLQVLDNLPHFVPGS 328
            :|..|...:..:::    |:.:.....|:.:.|      :.|...|:               ..:
Human   534 MLNNKVGNFKFIYV----DVISEEEAAPKKIKA------NRRSNSKK---------------SKT 573

  Fly   329 IEEWLQLLRLEEYIQPLLEQNYKTVRDVTQVTWEDLEDIGIVKLGHQKKILLAIKRV--KDIISG 391
            ::|:|:.:.|:||...||...|:|:.|:..:....|.::.|.....::::|.|.:..  ::||
Human   574 LQEFLERIHLQEYTSTLLLNGYETLEDLKDIKESHLIELNIENPDDRRRLLSAAENFLEEEII-- 636

  Fly   392 KWNPGGANAYQQQEYQRKPWQFNVPIP-STPSYVPTTRVSWDDTKIYATSSVLNSTAPSGSSCLN 455
                      |:||        |.|.| |..|.:...:...||             .|..|.|..
Human   637 ----------QEQE--------NEPEPLSLSSDISLNKSQLDD-------------CPRDSGCYI 670

  Fly   456 SSLANGD 462
            || .|.|
Human   671 SS-GNSD 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	12/75 (16%)
		SAM	260..316	CDD:197735	11/66 (17%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897	15/71 (21%)
		SAM	326..387	CDD:197735	14/62 (23%)
		Caskin-tail	<887..912	CDD:293238
SAMSN1	NP_001382787.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810