DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ckn and CASKIN2

DIOPT Version :9

Sequence 1:	NP_611009.1	Gene:	ckn / 36673	FlyBaseID:	FBgn0033987	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_065804.2	Gene:	CASKIN2 / 57513	HGNCID:	18200	Length:	1202	Species:	Homo sapiens

Alignment Length:	992	Identity:	210/992 - (21%)
Similarity:	318/992 - (32%)	Gaps:	353/992 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 ATVVGAPPPGAGKPGVAMVPPPPVFCATLREPLTHKAAVYYHQQLALQEDQGIDLTQSPGRDSPG 195
            |.:..||.|  .:||.:..|.||.     .|| .|........::.|          ||  |||.
Human   354 ARLPSAPTP--LRPGFSRTPQPPA-----EEP-PHPLTYSQLPRVGL----------SP--DSPA 398

  Fly   196 SSSGSAGS-GSRHSTASLDSGRASSYLTGVSSSGASIRAPLSSPRCSS----------------- 242
            ....|.|| ||..|..|..||::|.   |.:..|..:....:.|..|:
Human   399 GDRNSVGSEGSVGSIRSAGSGQSSE---GTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADN 460

  Fly   243 -----VSSCSIGS---VDRQRNDEL--------IIDWLLEMKHEEYAQLFIAAGYDLPTIARMTP 291
                 :::|..|.   ....|.::|        |.:||.|.:.|.|...|:.||||:|||:||||
Human   461 LSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTP 525

  Fly   292 EDLTAIGIKNPHHRERIKQRIDKLQVLDNLPHFVPGSIEEWLQLLRLEEYIQPLLEQNYKTVRDV 356
            |||||||:..|.||::|...|.:|.:.:.||.::|..:.|||..|.|.:|.:.|:...|.::..|
Human   526 EDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLV 590

  Fly   357 TQVTWEDLEDIGIVKLGHQKKILLAIKRVKDI-------------------------ISGKWN-P 395
            ..:|||:|::||:.|||||||::|.:||:.::                         |.|..| .
Human   591 ADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGE 655

  Fly   396 GGANA------YQQQEYQRK---------PWQFNVPIPSTPSYVPTTRVSWDDTKIYATSSVLNS 445
            |.|.|      :|..|...:         |    .|:|..|:..|:.......::....|....:
Human   656 GPATAGPRLLTFQGSELSPELQAAMAGGGP----EPLPLPPARSPSQESIGARSRGSGHSQEQPA 716

  Fly   446 TAPSG---SSCLNSSLANGDAYYCTGSNHECCS---GNDVVLIKVRQPRGKSLESLEDIHDNSTR 504
            ..|||   |.....:|..|     |....:.||   |..........|:|............:.
Human   717 PQPSGGDPSPPQERNLPEG-----TERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAP- 775

  Fly   505 SHLTFSHYTTTDYGHFGPPTT-----------------------------AAAAAAMAAAATLQQ 540
              ..||:..       |||.|                             ....:.:.:.|||.:
Human   776 --WAFSYLA-------GPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTR 831

  Fly   541 QHHHQQLLH--------------QQQQQAAAARLLG----------------------NNAPG-- 567
            :.....|:.              :.|..|..||..|                      :.:||
Human   832 RPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPK 896

  Fly   568 ---IGWRR---------SYDDGDITPTNDA--TRE------------------LLYEQEGGGTLP 600
               .|.||         |...|...|...|  |.|                  |.:.:||..|:.
Human   897 EGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIK 961

  Fly   601 RQQR-----------------GILQRAVLNTMPPLEHHHYMNAAAAAEYGAASGVEGGANYMGGS 648
            ::.:                 .:.:...:...|.......:..|..| :|.||...|.|     :
Human   962 QRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLA-FGVASATPGPA-----A 1020

  Fly   649 PLTGKKIAPEPPRRHCSIRNSRTLSGEGVPSG-AAAQAHQQAAQQQQGQHMFYGHTAQHWQQQQQ 712
            ||........||..........:|..:|||:. |.:.|.|.......|..: ....|..|..:.:
Human  1021 PLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGL-ESSAASRWNGETE 1084

  Fly   713 Q----------AGAGTGQQPIYANYATIQQTTAEIHCEK--YHDSKSTSSIDSIDTIPFANENTG 765
            .          .||||..:|:            .:.|.:  :...|....:......|...|:||
Human  1085 PPAAPAALLKVPGAGTAPKPV------------SVACTQLAFSGPKLAPRLGPRPVPPPRPESTG 1137

  Fly   766 TIKQRLLNRQELQGGGAGNNNVPGGGHPAHLHSSSSSSSSSSTNTIANIAHSFHSLKSSSSLHDA 830
            |:           |.|.....:.                                 ::||||..|
Human  1138 TV-----------GPGQAQQRLE---------------------------------QTSSSLAAA 1158

  Fly   831 TLARSESMGSTASGGSALHLRSPTLDMSNAGGSTAEPASSPEAAVPTVAINNGVPPKVSVNVLND 895
            ..|..:|:|                        |.|...:|.|:              :.::|:|
Human  1159 LRAAEKSIG------------------------TKEQEGTPSAS--------------TKHILDD 1185

  Fly   896 IGNMLANLTDELDAMLE 912
            |..|...|.|:|||||:
Human  1186 ISTMFDALADQLDAMLD 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	33/72 (46%)
		SAM	260..316	CDD:197735	30/55 (55%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897	28/94 (30%)
		SAM	326..387	CDD:197735	26/60 (43%)
		Caskin-tail	<887..912	CDD:293238	10/24 (42%)
CASKIN2	NP_065804.2	ANK	7..135	CDD:238125
		ANK repeat	7..46	CDD:293786
		ANK repeat	48..79	CDD:293786
		ANK 1	48..77
		Ank_2	53..145	CDD:289560
		ANK	76..209	CDD:238125
		ANK 2	81..110
		ANK repeat	85..112	CDD:293786
		ANK repeat	114..145	CDD:293786
		ANK 3	114..143
		ANK 4	147..176
		Ank_2	152..251	CDD:289560
		ANK repeat	158..219	CDD:293786
		ANK	183..311	CDD:238125
		ANK 5	188..217
		ANK 6	220..249
		ANK repeat	221..251	CDD:293786
		SH3_Caskin2	284..345	CDD:212996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..460		31/127 (24%)
		SAM_caskin1,2_repeat1	488..553	CDD:188896	31/64 (48%)
		SAM	494..549	CDD:197735	30/54 (56%)
		SAM_caskin1,2_repeat2	554..624	CDD:188897	28/69 (41%)
		SAM	560..621	CDD:197735	26/60 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..1104		74/453 (16%)
		Caskin-Pro-rich	798..883	CDD:293512	9/84 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1181		20/146 (14%)
		Caskin-tail	1145..1202	CDD:293238	22/127 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9825
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002692
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.770