DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ckn and caskin2

DIOPT Version :9

Sequence 1:	NP_611009.1	Gene:	ckn / 36673	FlyBaseID:	FBgn0033987	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_009304988.1	Gene:	caskin2 / 564253	ZFINID:	ZDB-GENE-041001-137	Length:	1308	Species:	Danio rerio

Alignment Length:	1065	Identity:	231/1065 - (21%)
Similarity:	378/1065 - (35%)	Gaps:	298/1065 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PQQLHHHHHQ----HPNHHHPHHQPSIPLYRLSGP-LRHHQNHQADDGISMSGSSIVSSP----- 90
            |.|.||...:    |.:||..|...|..||..:.| :.||.:.....|......|.:..|
Zfish   354 PVQRHHILSRALPSHNSHHTSHTDDSYTLYSSTHPTVTHHNSLDQHSGALPDSPSALCKPEDIWV 418

  Fly    91 ---SLEEGGFNLPRETSVALRLKDEVGGTSTAAPTTGGPGGGGATVVGAPPPGAGKPGVAMVPPP 152
               ||..|..|     |:         |::.:..::...|.|.:|....|..|
Zfish   419 LRTSLNAGDRN-----SI---------GSAGSMGSSRSAGSGQSTEGNFPNNG------------ 457

  Fly   153 PVFCATLREPLTHKAAVYYHQQLALQEDQGIDLTQSP-----------GRDSPGSSSGSAGSGSR 206
                     |....:||..:.::.....:.::..|.|           ||..|.|||........
Zfish   458 ---------PYQSPSAVQDNSKMPPSAGELLEQNQDPTKHMDPHSGALGRRIPLSSSRPGEQHVI 513

  Fly   207 HSTASLDSGRASSYLTGVSSSGASIRAPLSSPRCSSVSSCSIGSVDRQRNDELIIDWLLEMKHEE 271
            |....||....|..:..|..:                          .|:.|.|..||.|.:.|:
Zfish   514 HQQLLLDGRHTSKQINAVKRA--------------------------LRDAEAIYQWLCEFQLEQ 552

  Fly   272 YAQLFIAAGYDLPTIARMTPEDLTAIGIKNPHHRERIKQRIDKLQVLDNLPHFVPGSIEEWLQLL 336
            |...|:.||||:|||:|||||||||||:..|.||::|...|..|.:.:.||.::|..|.:||..:
Zfish   553 YTSNFLTAGYDVPTISRMTPEDLTAIGVTKPGHRKKISMEIGNLNIPEWLPDYIPSDIGKWLSAI 617

  Fly   337 RLEEYIQPLLEQNYKTVRDVTQVTWEDLEDIGIVKLGHQKKILLAIKRVKDIISGKWNPGGANAY 401
            .|.:|.:.|.|..|.::..|..:|||||::|||.|||||||::||:||:.|:...:.......|.
Zfish   618 GLPQYQKKLAENGYDSISIVQDITWEDLQEIGITKLGHQKKLMLAVKRLSDVQKARKTQAEGQAL 682

  Fly   402 QQQEYQRKPWQFNV---------PIPSTPSYVPTTRVSWDDTKIYATSSVLNSTAPSGSSCLNSS 457
            .|  :::.|....:         ..||:|  :....:::.|:::  :..:.|:.|.||
Zfish   683 LQ--HRKAPPALELVAIEHHDTSDCPSSP--LSPKMLTFQDSEL--SMELQNAMARSG------- 734

  Fly   458 LANGDAYYCTGSNHECCSGNDVVL----IKVRQ---------------PRGKSLESLEDIHDNST 503
                   |..|.:....||..:.|    |.:|.               |..:|.|||..  .:|:
Zfish   735 -------YSGGQDGLSMSGIAMRLSQESIGIRSGGSGRSQERPMASVTPHSRSQESLGS--SDSS 790

  Fly   504 RSHLTFSHYTTTDYGHFGPPTTAAAAAAMAAAATLQQQHHHQQL--------------------L 548
            .|...::...:.|.....|       ..||....||...:....                    :
Zfish   791 PSKEQYAIRESQDKSQISP-------VRMAPVLPLQPHPNSSSSSPSRTPPILTGKTTRFAYPPI 848

  Fly   549 HQQQQQAAAARLLGNNAP---GIGWRRSYD-DGDITPTNDATRELLYEQEGGGTLPRQQRGILQR 609
            |.|.:...:.......:|   |..:.:..: |.:........|.....|:...:..::.:.:.:.
Zfish   849 HTQSRPVVSPSQPNQGSPLQRGFSYLQHQNCDANKQKNTGPVRAAQPNQDTSCSTKKRTQSLSRY 913

  Fly   610 AVLN--------TMPPLEHHHYMNAAAAAEYGAASGVEG-------------GANYMGGSPLTGK 653
            |:.:        :.|.      |.:|..|.|...:...|             |.::........|
Zfish   914 AMSDGENEDDDVSAPT------MTSANVASYATLTRKPGRSQPSFALSDRHVGRSHSFAIRAKRK 972

  Fly   654 KIAPEPPRRHCSIRNSRTLSGEGVPSGAAAQAHQQAAQQQQG-------QHMFYG---------- 701
            ...|.||:|..|.::..|..|....|..:.::.....:...|       ..:|..
Zfish   973 GPPPPPPKRLSSAQSGVTSCGVETESAGSVRSIAARLESSTGSPSKTCNSPVFKAMSPATPPKNT 1037

  Fly   702 ----------------HTAQHWQQQQQQAGAGTGQQPI-YA--NYATIQQTT----AEIHCEKYH 743
                            |..|:....:.|.|:|:.|:.| :|  ...||:|.|    |:...|...
Zfish  1038 ENRRRTTSDCSTYETKHADQNVSPLRHQQGSGSSQESIPFAEEGKVTIKQRTKLASAKSEAEAAV 1102

  Fly   744 D-SKSTSSI-DSIDTIPFANENTGTIKQRLLNR-------------------------QELQGGG 781
            | .|...|| .|::.:.|..:.:.|:|:|...:                         |.:|.||
Zfish  1103 DILKPAQSIKSSLEVLEFNLKESDTVKRRHKPKELQMKGQGISAQIGNERATETEMVLQCMQNGG 1167

  Fly   782 AGNNNV-------PGGGH----PAH-LHSSSSSSSSSSTNTIANIAHSFHSLKSSSSLHDATLAR 834
            ...|.:       ||..|    |:. :..|::::|..|.:.:.::|.:.....|..:........
Zfish  1168 LRKNPLKSGLAPKPGSPHKPPTPSKPIRHSAAATSGVSMSVVQSVAFAVSPPCSPLACCPPNATP 1232

  Fly   835 SESMGSTASGGSAL-HLRSPTLDMSNAGGSTA-----------EPASSPEAAVPTVAINNGVPPK 887
            ......||.|.:.| |.|   |:.::.....|           :|||   ..:.||        |
Zfish  1233 QGQSALTAEGQNVLVHKR---LEQTSTSLQAALQVVERKLAQDDPAS---RGINTV--------K 1283

  Fly   888 VSVNVLNDIGNMLANLTDELDAMLE 912
            .:.|:|:|||||..:|.|:|||||:
Zfish  1284 SAGNILDDIGNMFDDLADQLDAMLD 1308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	33/64 (52%)
		SAM	260..316	CDD:197735	30/55 (55%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897	32/69 (46%)
		SAM	326..387	CDD:197735	29/60 (48%)
		Caskin-tail	<887..912	CDD:293238	14/24 (58%)
caskin2	XP_009304988.1	Ank_4	7..69	CDD:290365
		ANK repeat	7..46	CDD:293786
		ANK	43..168	CDD:238125
		ANK repeat	48..79	CDD:293786
		Ank_2	53..145	CDD:289560
		ANK repeat	81..112	CDD:293786
		ANK	114..235	CDD:238125
		ANK repeat	114..145	CDD:293786
		Ank_2	152..245	CDD:289560
		ANK repeat	158..213	CDD:293786
		ANK repeat	215..245	CDD:293786
		ANK repeat	247..281	CDD:293786
		SH3_Caskin2	278..339	CDD:212996
		Caskin1-CID	414..>451	CDD:293208	9/50 (18%)
		SAM_caskin1,2_repeat1	536..600	CDD:188896	33/63 (52%)
		SAM	537..589	CDD:197735	29/51 (57%)
		SAM_caskin1,2_repeat2	601..671	CDD:188897	32/69 (46%)
		SAM	607..668	CDD:197735	29/60 (48%)
		Caskin-Pro-rich	904..991	CDD:293512	14/92 (15%)
		Caskin-tail	1248..1308	CDD:293238	23/73 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9374
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002692
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.870