DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ckn and caskin1

DIOPT Version :9

Sequence 1:	NP_611009.1	Gene:	ckn / 36673	FlyBaseID:	FBgn0033987	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_009297876.1	Gene:	caskin1 / 563678	ZFINID:	ZDB-GENE-071115-3	Length:	1555	Species:	Danio rerio

Alignment Length:	1128	Identity:	250/1128 - (22%)
Similarity:	382/1128 - (33%)	Gaps:	411/1128 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SLKPHAS--------TAQAKKVQ------PPTIP------GDSPQDLHLYQQPQQLHHHHHQHPN 48
            |.:|.|:        |.|.:|:|      .|..|      |||..::|:...|.       ..|.
Zfish   350 SKRPGAAGSWSTVTCTQQYQKIQLCAPVCGPVSPAVAMVNGDSYHEIHILPPPP-------PPPP 407

  Fly    49 HHHPHHQPSIPLYRLSG-------PLRHHQNHQA---DDGISMSGSSIVSSPSLEEGGFNLPRET 103
            |.|      :||:...|       |...|...:|   .|..|..||.  |||.
Zfish   408 HSH------LPLFTSFGYNRSPNTPEEPHSGQEAKNDQDLASSRGSE--SSPH------------ 452

  Fly   104 SVALRLKDEVGGTSTAAPTTGGPGGGGATVVGAPPPGAGKPGVAMVPPPPVFCATLREPLTHKAA 168
                       |:.|.|   |||.||.:..:.                      .||:|:.
Zfish   453 -----------GSPTPA---GGPQGGSSEEIW----------------------VLRKPVA---- 477

  Fly   169 VYYHQQLALQEDQGIDLTQSPGRDSPGSSSG-----SAGSGSRHSTASL---------------- 212
                         |.|      |.|.|||..     |:|||....:.|:
Zfish   478 -------------GGD------RSSVGSSGSVASARSSGSGQSAGSTSILHAQAEGVKLLATVLS 523

  Fly   213 DSGRASSYLTGVSSS------GASIRAPLSSPRCSSVSSCSI-----GSVDRQR---------ND 257
            .|.:|..:|...:.|      .:|.:.|  |.|..|:|||.:     |....||         :.
Zfish   524 QSAKAKEHLLEQTKSLDHPSHASSNKGP--SSRSQSLSSCPLHEQPYGEAVSQRKGEAPPEGKSS 586

  Fly   258 ELIIDWLLEMKHEEYAQLFIAAGYDLPTIARMTPEDLTAIGIKNPHHRERIKQRIDKLQVLDNLP 322
            |.:|:||.|.:.:.||..||.||||:|||:|||||||||||:..|.||::|...|:|:.|.:.||
Zfish   587 EAVIEWLSEFQLQVYAPNFINAGYDIPTISRMTPEDLTAIGVTKPGHRKKITSEINKISVNEWLP 651

  Fly   323 HFVPGSIEEWLQLLRLEEYIQPLLEQNYKTVRDVTQVTWEDLEDIGIVKLGHQKKILLAIKRVKD 387
            ...|.|:.|||.::.|.:|.|.|::..|:.:..:|.:|||||::|||.|||||||::||:|::.:
Zfish   652 DQKPASLGEWLAMIGLSQYHQVLVQNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVKKLAE 716

  Fly   388 IISGKWNPGGANAYQQQEYQRKPWQFNVPIPSTPSYVPTTRVSWDDTKIYATSSVLNSTAPSGSS 452
            |   |....|.|.     .::||              |            |...|:...:|...|
Zfish   717 I---KKASDGRNT-----LRKKP--------------P------------AAQEVMAIESPPHDS 747

  Fly   453 --CLNSSLA-------NGDAYYCTGSNHECCSGNDVVLIKVRQPRGKSLESLEDIHDNSTRSHLT 508
              |::..::       :|:.........:...|.:|......|.|.:||      |:||    :.
Zfish   748 GECMSPKMSTFQDSELSGELQAALTRPADVQDGTEVRTNSGPQHRARSL------HENS----IN 802

  Fly   509 FSHYTTTDYGHFGPPTTAAAAAAMAAAATLQQQHHHQQLLHQQQQQAAAARLLGNNAPGIGWRRS 573
            .|..|..   |.|||...|..                    .:|......|.:.::.|..  |:|
Zfish   803 KSRDTEE---HSGPPKKEART--------------------MRQSSQGGQRNVSSSQPKP--RQS 842

  Fly   574 YDDG---DITPTNDATR--------------------ELLYEQE------GGGTLPRQQ------ 603
            |..|   ..||....|:                    :::.:.|      |....|.|:
Zfish   843 YPQGTGPPYTPPQTPTKTKPPASQTTSNPPGKPKPSPQIVQQTEKPITPRGHPQSPTQRSHPHPA 907

  Fly   604 -----------RGILQRAVLNTMP------------PLEHHHYMNAAAAAE-------------- 631
                       :|......|..:|            |.:..|.:|..|.::
Zfish   908 AQPVESIEAPPQGPAVSVPLLCLPPDGDEACDEYGLPKKRAHSLNRYAVSDGEQERDELNVPDSG 972

  Fly   632 --YGAASGVEGGANYMGGS-----------PLTGKKIA--PEPPRRHCSIRNSRTLS-------- 673
              |.......|.:|.|.|.           .|..||..  |.||:|..|..:|.:.:
Zfish   973 GKYATVQPRVGRSNSMKGQADKNVNRSQSFALRQKKKGPPPPPPKRSSSAISSSSSNLTEVPKET 1037

  Fly   674 -------------------GEGVPSGAAAQAHQQAAQQQQ------GQHMFYGHTAQHWQQQQQQ 713
                               |..|.:|:|......||..:.      .:.:....:|.|:    .|
Zfish  1038 NSGPLLDIPYQPQRRASDLGGTVDTGSAGSVRSIAAMLEMSSIGGGAKGLALQKSAGHY----LQ 1098

  Fly   714 AGAGTGQQ------------------PIYANYATIQQTTAEIHCEKYHDSKSTSSIDSIDTIPFA 760
            .|:|..|:                  |:....|..::....|...:..:::.:||..|.:.:|||
Zfish  1099 VGSGAKQRDAIGLDGEVVNRRRTISGPVTDLVAAAKRGPELIQDRQCTEAQPSSSGSSAENLPFA 1163

  Fly   761 NENTGTIKQR-LLNRQELQGGGAGNNNVPGGGHPAHLHSSSSSSSSSSTNTIANIAH-----SFH 819
            .:...||||| ...:.|.:.|...:.::|      |...|.:.|::|...::....|     .||
Zfish  1164 EDGNLTIKQRPRQGKDEAEEGLEISYSLP------HEDLSRADSTASLKRSVQTTRHQPNGTKFH 1222

  Fly   820 SLKSS-------SSLHDATLARSESMGSTASGGSALHLRSPTLD--MSNAGGSTAEPASSPE--- 872
            ..:|:       |...||...:...|......|:....|.|..|  :|........|.:||.
Zfish  1223 LTESNTVKRRPKSKDKDAEELQDGQMPVPYENGTGTIKRRPASDVTVSEQPRPQEHPENSPRRDS 1287

  Fly   873 --------AAVPTVAINNGVPPK 887
                    .:.|..::...|.||
Zfish  1288 ADLEGHVTESTPRKSVKPPVSPK 1310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	36/73 (49%)
		SAM	260..316	CDD:197735	32/55 (58%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897	32/69 (46%)
		SAM	326..387	CDD:197735	29/60 (48%)
		Caskin-tail	<887..912	CDD:293238	1/1 (100%)
caskin1	XP_009297876.1	Ank_4	7..69	CDD:290365
		ANK repeat	7..46	CDD:293786
		ANK	43..168	CDD:238125
		ANK repeat	48..79	CDD:293786
		Ank_2	53..145	CDD:289560
		ANK repeat	81..112	CDD:293786
		ANK	109..241	CDD:238125
		ANK repeat	114..145	CDD:293786
		Ank_2	119..218	CDD:289560
		ANK repeat	147..186	CDD:293786
		ANK repeat	188..218	CDD:293786
		Ank_5	208..261	CDD:290568
		ANK repeat	221..251	CDD:293786
		SH3	288..349	CDD:302595
		Caskin1-CID	467..524	CDD:293208	15/101 (15%)
		SAM	581..644	CDD:197735	32/62 (52%)
		SAM_caskin1,2_repeat1	583..648	CDD:188896	34/64 (53%)
		SAM_caskin1,2_repeat2	649..719	CDD:188897	32/72 (44%)
		SAM	655..716	CDD:197735	29/60 (48%)
		Caskin-Pro-rich	944..1013	CDD:293512	12/68 (18%)
		Caskin-tail	1496..1555	CDD:293238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9374
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002692
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3720
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.900