DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ckn and Sash1

DIOPT Version :9

Sequence 1:	NP_611009.1	Gene:	ckn / 36673	FlyBaseID:	FBgn0033987	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_038957407.1	Gene:	Sash1 / 365037	RGDID:	1566017	Length:	1397	Species:	Rattus norvegicus

Alignment Length:	877	Identity:	161/877 - (18%)
Similarity:	269/877 - (30%)	Gaps:	299/877 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 TLREPLTHKAAVYYHQQLALQEDQGIDLTQSPG-----------RDSPGSSSGSA---------- 201
            |:|:.::.|     :.....::|.|:|.|  ||           .|.|...:|.:
  Rat   619 TMRKRMSKK-----YSSPVTEQDSGLDGT--PGSPTSVKPDSEHMDKPKLKAGGSVESLRSSLSG 676

  Fly   202 -GSGSRHSTASLDSGRASSYLTGVSSSGASIRAPLSSPRCS--------SVSSCSIGSVDRQRND 257
             .|.|.|:.::.||. .|:..:..|..|.....|...|.|.        :.|.....|:..::.|
  Rat   677 QSSMSGHTVSTTDSS-TSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGD 740

  Fly   258 ELIID---------W--LLEMKHEEYAQLFIAAGYDLPTIARMTPEDLTAIGIKNPHHRERIKQR 311
              |||         |  ||..|...:..:::    |:.......|        |.|..|.| |.|
  Rat   741 --IIDIISKPPMGTWMGLLNNKVGTFKFIYV----DVLNEEEEKP--------KRPTRRRR-KGR 790

  Fly   312 IDKLQVLDNLPHFVPGSIEEWLQLLRLEEYIQPLLEQNYKTVRDVTQVTWEDLEDIGIVKLGHQK 376
            ..:           |.|:|:.|..:.|:|::...|...|:.:.....:..|||:::.|....|:.
  Rat   791 PSQ-----------PKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRA 844

  Fly   377 KILLAIKRVKDIISGKWNPGGANAYQQQEYQRKPWQFNVPIPSTPSYVPTTRVSWDDTKIYATSS 441
            .:|.|::.:                  |||.....|                 |....|:.|.|.
  Rat   845 VLLTAVELL------------------QEYDSNSDQ-----------------SGSQEKLLADSQ 874

  Fly   442 VLNSTAPSGSSCLNSS--LANGDAYYCTGSNHECCSGNDVVLIKVRQPRGKSLESLEDIHDNSTR 504
            .|:..:|..|.|..||  |.||                     |.::|...|.:|       ||.
  Rat   875 GLSGRSPRDSGCYESSENLENG---------------------KTQKPSALSTKS-------STE 911

  Fly   505 SHLTFSHYTTTDYGHFGPPTTAAAAAAMAAAATLQQQHHHQQL-------------------LHQ 550
            |:|  ..:..:..|::  ||     ..:..:..:::|....:|                   |.:
  Rat   912 SNL--KSFNRSQPGNY--PT-----LPLTKSGEVRKQGEESRLGRGLAPDTAKCCDVPCVTGLSK 967

  Fly   551 QQQQ-----AAAARLLGNNAPGIGWRRSYDDGDITPTNDATRELLYEQEGGGTLPRQQRGILQRA 610
            .::.     ..:...|....|...|.||:...|:....|..:::..|:.  .|.|.....:.|:|
  Rat   968 NRRSLPVSICRSCETLEGPEPVESWPRSHSLDDLQGDADVGKDVPTEKP--ETCPENVPEVPQKA 1030

  Fly   611 VLNTMPPLEHHHYMNAAAAAEYGAASGVEGGANYMGGSP-------LTGKKIAPEPPRRHCSIRN 668
            ...|...|..                         |..|       ||..|...:||:     ..
  Rat  1031 SACTSKALPR-------------------------GRDPTAEDVMFLTQSKRFSDPPK-----TM 1065

  Fly   669 SRTLSGEGVPSGAAAQAHQQAAQQQQGQ-------------HMFYGHTAQHWQQQQQQAGAGTGQ 720
            ::.|.|..|.|.......|...:..:.|             .:..||  .|.....::...|
  Rat  1066 AKKLEGSAVASNLGIAPPQCIPRNFEAQPPVKPGLTRTSLEGLRKGH--DHHSLGTKEGVDG--- 1125

  Fly   721 QPIYANYATIQQTTAEIHCEKYHDSKSTSSIDSIDTIPFANENTGTIKQRLLNRQELQGGGAGNN 785
                      :|:|.|...:..|.|:.       ..:|....     ::||.|         |.:
  Rat  1126 ----------EQSTPETRTQSRHPSQP-------PPVPAKKS-----RERLAN---------GLH 1159

  Fly   786 NVPGGGHP-AHLHSSSSSS--------------SSSSTNTIANIAHS----FHSLKSSSSLHDAT 831
            .||....| ..|..:|.:|              |||.|...:.:...    ...|..|:||.:..
  Rat  1160 LVPSPEAPILPLKKASPASPVSPSDCPSPREPRSSSGTEPGSPVCTRPPPWLAELPESTSLQEHG 1224

  Fly   832 LARSESMGSTASGGSALHLRSPTLDMSNAGG--STAEPASS-------PEAAVPTVAINNGVPPK 887
            :.....:....|....:.|...|.:...|.|  .|.||.|.       |||.|...|.:...|.:
  Rat  1225 VKLGPVLSRKVSCIRGVDLEMLTENKLQAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPER 1289

  Fly   888 VSVNVLNDIGNMLANLTDELDAMLEEEKRVGL 919
                      ::.||:......:|.::.|:.:
  Rat  1290 ----------DVAANMDQIRVKLLRKQHRMAI 1311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	16/75 (21%)
		SAM	260..316	CDD:197735	15/66 (23%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897	15/69 (22%)
		SAM	326..387	CDD:197735	15/60 (25%)
		Caskin-tail	<887..912	CDD:293238	2/24 (8%)
Sash1	XP_038957407.1	SLY	562..714	CDD:403621	21/102 (21%)
		SH3_SASH1	716..772	CDD:212900	11/61 (18%)
		SAM_SASH1_repeat1	793..857	CDD:188958	17/92 (18%)
		PHA03247	<981..1208	CDD:223021	51/294 (17%)
		SAM_SASH1_repeat2	1323..1392	CDD:188891
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900