DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ckn and Sash3

DIOPT Version :9

Sequence 1:	NP_611009.1	Gene:	ckn / 36673	FlyBaseID:	FBgn0033987	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_006257592.1	Gene:	Sash3 / 317578	RGDID:	1560293	Length:	381	Species:	Rattus norvegicus

Alignment Length:	435	Identity:	87/435 - (20%)
Similarity:	144/435 - (33%)	Gaps:	126/435 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SGPLRHHQNHQADDGISMSGSSIVSSPSLEEGGFNLPRETSVAL--------------RLKDEVG 114
            |.|:...:....||.|....|.:::.....:.|..|.::....:              .|.:|:|
  Rat    37 SSPVVSEKEFNLDDNIPEDDSGVLTPEDSGKSGKKLGKKWRAVISRTMNRKMGKMMVKALSEEMG 101

  Fly   115 GT---STAAPTTGGPGGGGATVVGAPPPGAGKPGVAMVPPPPVFCATLREPLTHKAAVYYHQQLA 176
            .|   .:|:||:..        .....||..|..:|...|..      ||.|.          |:
  Rat   102 DTLEEGSASPTSPD--------CSLDSPGPEKMALAFSEPEE------RELLA----------LS 142

  Fly   177 LQEDQGIDLTQSPGRDSPGSSSGSAGSGSRHSTASLDSGRASSYLTGVSSSGASIRAPLSSPRCS 241
            .|...|.:|.      |||..|||          .::...|..| ||.....|.:....:.
  Rat   143 RQTSTGSELC------SPGPGSGS----------FIEESPAPQY-TGPFCGRARVHTDFTP---- 186

  Fly   242 SVSSCSIGSVDRQRNDEL-IID------W--LLEMKHEEYAQLFIAAGYDLPTIARMTPEDLTAI 297
              |.....|:..|:.|.: ||:      |  ||..|...:..:::          .:.||:  |:
  Rat   187 --SPYDHDSLKLQKGDVIQIIEKPPVGTWLGLLNGKLGSFKFIYV----------DVLPEE--AV 237

  Fly   298 GIKNPHHRERIKQRIDKLQVLDNLPHFVPGSIEEWLQLLRLEEYIQPLLEQNYKTVRDVTQVTWE 362
            |...|..|:...:|          |.  |.::.|.|:.:.|||:...||...|:|:.|..::...
  Rat   238 GPVRPSRRQSKSKR----------PK--PKTLHELLERIGLEEHTSTLLLNGYQTLEDFKELRET 290

  Fly   363 DLEDIGIVKLGHQKKILLAIKRVKDIISGKWNPGGANAYQQQEYQRKPWQFNVPIPSTPSYVPTT 427
            .|.::.|:...|:.|:|.|.:.:.|..:.    |...|.:..|..::|....|..|..
  Rat   291 HLNELNIMDPQHRAKLLTAAELLLDYDTA----GSEEAEEGAESSQEPALHTVSEPKV------- 344

  Fly   428 RVSWDDTKIYATSSVLNSTAPSGSSCLNSSLANGDAYYCTGSNHE 472
                              ..|..|.|...|.:..|....||:..:
  Rat   345 ------------------DIPRDSGCFEGSESGRDEAELTGTEEQ 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	15/73 (21%)
		SAM	260..316	CDD:197735	13/63 (21%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897	19/69 (28%)
		SAM	326..387	CDD:197735	17/60 (28%)
		Caskin-tail	<887..912	CDD:293238
Sash3	XP_006257592.1	SLY	21..174	CDD:289268	37/177 (21%)
		SH3_SASH3	176..231	CDD:212901	11/70 (16%)
		SAM_superfamily	250..317	CDD:301707	20/78 (26%)
		SAM	252..316	CDD:197735	18/65 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810