Protein Alignment ckn and Caskin2

DIOPT Version :9

• Sequence 1: NP_611009.1
• Gene: ckn / 36673
• FlyBaseID: FBgn0033987
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_001100535.1
• Gene: Caskin2 / 303678
• RGDID: 1309738
• Length: 1200
• Species: Rattus norvegicus
• Alignment Length: 1005
• Identity: 215/1005 - (21%)
• Similarity: 319/1005 - (31%)
• Gaps: 356/1005 - (35%)

  Fly   130 GATVVGAPPPG--------AGKPGVAMVPPPPVFCATLREP----LTHKAA------VYYHQ--Q 174
            |...||..|||        .|.| |..:|..|    ||..|    ::..:|      :.|.|  :
  Rat   330 GTDRVGYFPPGIVEVVSKRVGIP-VTRLPSAP----TLLRPSFSRISQPSADDPLPSLTYGQLPR 389

  Fly   175 LALQEDQGIDLTQSPGRDSPGSSSGSAGSG------SRHSTA-------SLDSGRASSYLTGV-- 224
            :.|..|.......|.|.:....|..|||||      :.|||.       .|.|......|.|:
  Rat   390 VGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHSTGLLIENAQPLPSANEDQVLPGLHA 454

  Fly   225 -SSSGASIRAPLSSPRCSSVSSCSIGSVDRQRNDEL--------IIDWLLEMKHEEYAQLFIAAG 280
             |.:......||:|.|...:.:..:      |.::|        |.:||.|.:.|.|...|:.||
  Rat   455 PSPADNLSHRPLASYRSGEIFTQDV------RPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAG 513

  Fly   281 YDLPTIARMTPEDLTAIGIKNPHHRERIKQRIDKLQVLDNLPHFVPGSIEEWLQLLRLEEYIQPL 345
            ||:|||:|||||||||||:..|.||::|...|.:|.:.:.||:::|..:.|||..|.|.:|.:.|
  Rat   514 YDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPNYIPVDLLEWLCALGLPQYHKQL 578

  Fly   346 LEQNYKTVRDVTQVTWEDLEDIGIVKLGHQKKILLAIKRVKDIISGKWNPGGANAYQQQEYQRKP 410
            :...|.::..|..:|||:|::||:.|||||||::|.:||:.::..|
  Rat   579 VSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRG------------------- 624

  Fly   411 WQFNVPIPSTPSYVPTTRVSWDDTKIYATSSVLNSTAPSGSSCLNSSLANGDAYYCTGSNHECCS 475
                                                           |.:|:|....|.
  Rat   625 -----------------------------------------------LLHGEALGEGGR------ 636

  Fly   476 GNDVVLIKVRQPRGKSLESLEDIHDNSTRSH-----LTFSHYTTTDYGHFGPPTTAAAAAAMAAA 535
                     |..||..|.::|.:.:..:.:.     |||.          |...:....||||..
  Rat   637 ---------RMTRGPELMAIEGLENGDSPATAGPRLLTFQ----------GSELSPELQAAMAGG 682

  Fly   536 ATLQQQHHHQQL----LHQQQQQAAAARLLGN-----------NA--PGIGWRRSYDDGDITPTN 583
            ..       :.|    .....|::..||..|:           ||  |.....|:..:|...|..
  Rat   683 GP-------EPLPLPPARSPSQESIGARSRGSGHSQGQPGSQPNAGEPSAPQERNLPEGTERPFK 740

  Fly   584 DAT--------------RELLYEQEGGGTLPRQQRGILQRAVLNTMP-----PLEHHHYMNAAAA 629
            ..:              .:.|.........|...|.....|..:..|     |....|.::....
  Rat   741 PCSPLPGQGPAPYVFMCPQSLPSSPAPAPPPGVPRAFSYLAGSSAAPPDPPRPKRRSHSLSRPGP 805

  Fly   630 AEYGAASGVEGGANYMGGS---------------------PLTG-------------KKIAPEPP 660
            ||..|....||......||                     |..|             |...|.||
  Rat   806 AEGEAEGEAEGPVGSALGSYATLTRRPGRSTLARTSPSLTPTRGTPRSQSFALRARRKGPPPPPP 870

  Fly   661 RRHCSIRNS---RTLSGEGVPSGAAAQAHQQAAQQQQGQHMFYGHTAQHWQQQQQQAGAGTGQQP 722
            :|..|:..|   .:|.|...|...||...::...:..|            ..:.....|.||
  Rat   871 KRLSSVSGSTEPTSLEGTSGPKEGAAGPRRRTLSEPTG------------PSESPAPSAPTG--- 920

  Fly   723 IYANYATIQQTTAEIHCEKYHDSKSTSSIDSIDTIPFANENTGTIKQR----------------- 770
                  .:..|..|   |...:....|...|.:.:|||.|...|||||
  Rat   921 ------PVSDTEEE---EPVLEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETTVPPGL 976

  Fly   771 ---------------LLNRQELQGG----GAGNNNVPGGGHPAHLHSSSSSSSSSSTNTIANIAH 816
                           ...|:.|:..    |...::.||...|....:...:.|:.| |...:...
  Rat   977 DFNLTESDTVKRRPKCKEREPLRTALLAFGVVGSDTPGPSTPLSSQAPCEAPSAPS-NPPRSEPS 1040

  Fly   817 SFHSLKSSSSLHDATL-----ARSESMGSTASGGSALHLRS-----PTLDMSNAGGSTA------ 865
            |..|.::.:.|...|.     ..|...|...|.||..::.:     |...:...|..||
  Rat  1041 SLPSQEAPAPLSPVTQPPGHPGPSAGPGLETSTGSRQNVDTEPPAPPAALLKVPGAGTAPKPVSV 1105

  Fly   866 ------------------------------------------EPASSPEAAVPTVAIN------N 882
                                                      :.:||.|||:.....|      :
  Rat  1106 ACTQLAFSGPKLAPRLGPRPVPPPRPENTGPVCPGRAQQRLEQTSSSLEAALRAAEKNIGSEEQD 1170

  Fly   883 GVPPKVSVNVLNDIGNMLANLTDELDAMLE 912
            |.....:.::|:||..|...|.|:|||||:
  Rat  1171 GPTGPSTKHILDDISTMFDALADQLDAMLD 1200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	33/72 (46%)
		SAM	260..316	CDD:197735	30/55 (55%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897	28/69 (41%)
		SAM	326..387	CDD:197735	26/60 (43%)
		Caskin-tail	<887..912	CDD:293238	10/24 (42%)
Caskin2	NP_001100535.1	ANK	7..135	CDD:238125
		Ank_4	7..61	CDD:290365
		ANK repeat	7..46	CDD:293786
		ANK repeat	48..79	CDD:293786
		Ank_2	53..145	CDD:289560
		ANK	76..209	CDD:238125
		ANK repeat	85..112	CDD:293786
		ANK repeat	114..145	CDD:293786
		Ank_2	152..251	CDD:289560
		ANK repeat	158..219	CDD:293786
		ANK	183..>258	CDD:238125
		ANK repeat	221..251	CDD:293786
		SH3_Caskin2	284..345	CDD:212996	6/14 (43%)
		SAM_caskin1,2_repeat1	487..552	CDD:188896	31/64 (48%)
		SAM	493..548	CDD:197735	30/54 (56%)
		SAM_caskin1,2_repeat2	553..623	CDD:188897	28/69 (41%)
		SAM	561..620	CDD:197735	25/58 (43%)
		Caskin-Pro-rich	797..881	CDD:293512	17/83 (20%)
		Draxin	899..>1067	CDD:292187	32/192 (17%)
		Caskin-tail	1143..1200	CDD:293238	17/56 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9589
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002692
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.870