DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ckn and Caskin1

DIOPT Version :9

Sequence 1:	NP_611009.1	Gene:	ckn / 36673	FlyBaseID:	FBgn0033987	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_006524376.1	Gene:	Caskin1 / 268932	MGIID:	2442952	Length:	1438	Species:	Mus musculus

Alignment Length:	974	Identity:	216/974 - (22%)
Similarity:	337/974 - (34%)	Gaps:	308/974 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 QHPNHHHPHHQPSIPLYRLSGPLRHHQNHQADDGI----SMSGSSIV--------SSPSLEEGGF 97
            |||:.            |..|.:  |.|...:|.:    |..|.:||        |.||..:||.
Mouse   321 QHPDG------------RWKGCI--HDNRTGNDRVGYFPSSLGEAIVKRAGSRTGSEPSPPQGGG 371

  Fly    98 NL----PRETSVALRLKDEVGG--TSTAAPTTGGPGGGG-------------ATVVGAPPPGAGK 143
            :|    |.|....|| |...||  :.:.:...||...||             |||:.........
Mouse   372 SLGPSAPPEEIWVLR-KPFAGGDRSGSLSNVAGGRSTGGHALHAGSEGVKLLATVLSQKSVSESS 435

  Fly   144 PGVAMVPPPPVFCATLRE--PLTHKAAVYYHQQLALQEDQGIDLTQSPGRDSPGSSSGSAGSGSR 206
            ||.:.|.||.......|.  |..|...||..|.....|                |:|.||..|
Mouse   436 PGDSPVKPPEGSSGAARSQPPAAHAGQVYGEQPPKKLE----------------SASASASEG-- 482

  Fly   207 HSTASLDSGRASSYLTGVSSSGASIRAPLSSPRCSSVSSCSIGSVDRQRNDELIIDWLLEMKHEE 271
                                                            ::.|.:..||...:.:.
Mouse   483 ------------------------------------------------KSAEAVSQWLATFQLQL 499

  Fly   272 YAQLFIAAGYDLPTIARMTPEDLTAIGIKNPHHRERIKQRIDKLQVLDNLPHFVPGSIEEWLQLL 336
            ||..|.:||||||||:|||||||||||:..|.||::|...|..|.:.|.||...|.::..||.::
Mouse   500 YAPNFTSAGYDLPTISRMTPEDLTAIGVTKPGHRKKITAEISGLNIPDWLPEHKPANLAVWLSMI 564

  Fly   337 RLEEYIQPLLEQNYKTVRDVTQVTWEDLEDIGIVKLGHQKKILLAIKRVKDIISGKWNPGGANAY 401
            .|.:|.:.|::..|:.:..:|.:|||||::|||.|||||||::||::::.::...::     :.|
Mouse   565 GLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVRKLAELQKAEY-----SKY 624

  Fly   402 QQQEYQRKPWQ------FNVPIPSTPSYV----PTTRVSWDDTKIYATSSVLNSTAPSGSSCLNS 456
            :....:||..|      ...|.||.|:..    |......|........:.|:..|.:|::.:..
Mouse   625 EGGPLRRKTPQSLEMMAIESPPPSEPAAAECQSPKMTTFQDSELSGELQAALSGPAEAGAAAVEK 689

  Fly   457 SLANGDAYYCTGSNHECCSGNDVVLIKVRQPRGKSLESLEDIHDNSTRSHLTFSHYTTTDYGHFG 521
            |           |||.
Mouse   690 S-----------SNHL------------------------------------------------- 694

  Fly   522 PPT--TAAAAAAMAAAATLQQQHHHQQLLHQQQQQAAAARLLGNNAPGIGWRRSYDDGDITPTND 584
            |||  |.:..::::..|               :..:::..|||:..||.|          :|.:.
Mouse   695 PPTPRTTSRESSLSGRA---------------RHISSSQELLGDGPPGPG----------SPMSR 734

  Fly   585 ATRELLYEQEGGGTLPRQQRG-----ILQRAVLNTMPPL------------EHHHYMNAAAAAEY 632
            :...||.|....||.|::.|.     .::||   ::||:            .|.........|:.
Mouse   735 SQEYLLDEGMAPGTPPKEVRSSRHGHSVKRA---SVPPVPGKPRQVLPSGASHFTPPQTPTKAQP 796

  Fly   633 GAASGVEGGANYMGGSPLTGK-KIAPE--PPRRHCSIRNSRTLSGEGVPSGAAAQAHQQAAQQQQ 694
            |:...: ||.:    .|.|.| |..|:  ||       ..|.:|...:|              |.
Mouse   797 GSPQAL-GGPH----GPATAKVKPTPQLLPP-------TDRPMSPRSLP--------------QS 835

  Fly   695 GQHMFYGHTAQHWQQQQQQAG---AGTGQQPIYANYATI---QQTTAE-------IH-CEKYHDS 745
            ..|..:.:...  |..:.:.|   .|....|:.|...|:   .:|..|       .| ..:|..|
Mouse   836 PTHRGFAYVLP--QPVEGEVGPPAPGPAPPPVPAAVPTLCLPPETDVEPGRPKKRAHSLNRYAAS 898

  Fly   746 KSTSSIDSIDTIPFANENTGTIKQRLLNRQELQGGGAGNNNV---------PGGGHPAHLHSSSS 801
            .|....|.: .:|.|.....|:::|:.....::.....:.||         |....|.......|
Mouse   899 DSEPERDEL-LVPAAAGPYATVQRRVGRSHSVRAPAGTDKNVNRSQSFAVRPRKKGPPPPPPKRS 962

  Fly   802 SSSSSSTNTIANIAHSFHSLKSSSSLHDATLARSESMGS--TASGGSALHLRSPTLDMSNAGGS- 863
            ||:.:|.|.....|....:......:.......|:..||  |.|.||...: :..|::|:.||.
Mouse   963 SSAMASANLADEPAPDVEAEDGRLGVRAQRRRASDLAGSVDTGSAGSVKSI-AAMLELSSIGGGG 1026

  Fly   864 -----------TAEPASSPEAAVPTVAINNGVPPKVSVNVLNDIGNMLANLTDELDAMLEEEKR 916
                       |..|||.....|.||..:  |..|.::....::.|....|:..:..:|...:|
Mouse  1027 RAIRRPPEGHPTPRPASPEPGRVATVLAS--VKHKEAIGPDGEVVNRRRTLSGPVTGLLATARR 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	31/64 (48%)
		SAM	260..316	CDD:197735	29/55 (53%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897	27/69 (39%)
		SAM	326..387	CDD:197735	25/60 (42%)
		Caskin-tail	<887..912	CDD:293238	3/24 (13%)
Caskin1	XP_006524376.1	Ank_2	7..86	CDD:393464
		ANKYR	55..258	CDD:223738
		ANK repeat	56..86	CDD:293786
		ANK repeat	88..119	CDD:293786
		ANK repeat	121..152	CDD:293786
		Ank_2	126..225	CDD:372319
		ANK repeat	154..193	CDD:293786
		ANK repeat	195..225	CDD:293786
		ANK repeat	228..258	CDD:293786
		Ank_2	232..>289	CDD:393464
		ANK repeat	260..294	CDD:293786
		SH3_Caskin1	291..352	CDD:212995	10/44 (23%)
		Caskin1-CID	380..428	CDD:374660	13/48 (27%)
		SAM_caskin1,2_repeat1	482..547	CDD:188896	32/114 (28%)
		SAM_caskin1,2_repeat2	548..618	CDD:188897	27/69 (39%)
		PTZ00449	<694..>836	CDD:185628	39/244 (16%)
		Caskin-Pro-rich	885..956	CDD:374879	13/71 (18%)
		Caskin-tail	1376..1438	CDD:374688
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9778
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002692
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3720
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.900