DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ckn and SASH1

DIOPT Version :9

Sequence 1:	NP_611009.1	Gene:	ckn / 36673	FlyBaseID:	FBgn0033987	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_016866087.1	Gene:	SASH1 / 23328	HGNCID:	19182	Length:	1410	Species:	Homo sapiens

Alignment Length:	366	Identity:	86/366 - (23%)
Similarity:	122/366 - (33%)	Gaps:	98/366 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RSLKPHASTAQAKKVQPPTIPGDSPQDLH-LYQQPQQLHHHHHQHPNHHHP-----------HHQ 55
            |.|.|.....:....|||...       | |.:.|.:.|...|:....|||           ..|
Human  1083 RGLSPPQCLPRNYDAQPPGAK-------HGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQ 1140

  Fly    56 PSIPLYRLSGPLRHHQNHQAD--DGISMSGSSIVSSPSLEEGGFNLPRETSVALRLKDEVGGTST 118
            |.||......|.:..:...|:  ..:.|..|..:.||...    .||            |...|.
Human  1141 PKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAP----CLP------------VKRGSP 1189

  Fly   119 AAPTTGGPGGGGATVVGAPPPGAGK-PGVAMVPPPPVFCATLRE-------------PLTHKAAV 169
            |:||:  |......:  ||.|.:|: ||......||.:.:.|.|             .||.|.:.
Human  1190 ASPTS--PSDCPPAL--APRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSC 1250

  Fly   170 YYHQQL-ALQED----QGIDLTQSPGRDSPGSS----------SGSAGSGSRHSTASLDSGRA-- 217
            .....| .|.|:    :|||||:.|..|..|..          :.......|...|::|..|.
Human  1251 ARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQ 1315

  Fly   218 --SSYLTGVSSSGAS--IRAPLSSPRC-SSVSSCSIGSVDRQRNDELIIDWLLEMKHEEYAQLFI 277
              ..:...:.|.|.:  .|.|: ||.| ||||                 |||:.:....||....
Human  1316 LRKQHRMAIPSGGLTEICRKPV-SPGCISSVS-----------------DWLISIGLPMYAGTLS 1362

  Fly   278 AAGYD-LPTIARMTPEDLTAIGIKNPHHRERI--KQRIDKL 315
            .||:. |..:..::...|...||....|..::  ..|:.||
Human  1363 TAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKL 1403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	15/65 (23%)
		SAM	260..316	CDD:197735	15/59 (25%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897
		SAM	326..387	CDD:197735
		Caskin-tail	<887..912	CDD:293238
SASH1	XP_016866087.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810