DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ckn and Y106G6H.14

DIOPT Version :9

Sequence 1:	NP_611009.1	Gene:	ckn / 36673	FlyBaseID:	FBgn0033987	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_492738.1	Gene:	Y106G6H.14 / 172926	WormBaseID:	WBGene00013724	Length:	220	Species:	Caenorhabditis elegans

Alignment Length:	244	Identity:	47/244 - (19%)
Similarity:	77/244 - (31%)	Gaps:	84/244 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 APPPGAGKPGVAMVPPPPVFCATLREPLTHKAAVYYHQQLALQEDQGIDLTQSPG------RDSP 194
            ||||.|.|||...|                ..|:|..|..:.||     ||.|.|      .:.|
Worm     8 APPPPAPKPGRVKV----------------YRALYDFQARSAQE-----LTFSEGDLMYVSDEQP 51

  Fly   195 GSSSGSAGSGSRHSTASLDSGRASSYLTGVSSSGASIRAPLSSP----RCSSVSSC-----SIGS 250
            ......|..|.:....      .::|:  :|.:...:..||...    ....::.|     |:.|
Worm    52 NKDWFQASIGGKKGLV------PANYV--ISENVEELPNPLHEAARRGNMDMLAECLRERVSVNS 108

  Fly   251 VDRQRNDELIIDWLLEMKHEEYAQLFIAAGYDLPTIARMTPEDLTAIGIKN-----PHHRERIKQ 310
            :|:.....|.  |   ..|..:|          |.:..:..:...|:.::|     |.|....|.
Worm   109 LDKSGATPLY--W---ASHGGHA----------PAVDTLLKDPKVAVSVQNKLGDTPLHAAAYKG 158

  Fly   311 RIDKLQVLDNLPHFVPGSIEEWLQLLRLEEYIQPLL-EQNYKTVRDVTQ 358
            .::.:::|                   |.....|.: .|:.|...|||:
Worm   159 HVECVRLL-------------------LASSANPFVRNQDQKLPSDVTK 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	10/69 (14%)
		SAM	260..316	CDD:197735	9/60 (15%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897	7/40 (18%)
		SAM	326..387	CDD:197735	7/34 (21%)
		Caskin-tail	<887..912	CDD:293238
Y106G6H.14	NP_492738.1	SH3_OSTF1	21..74	CDD:212706	14/81 (17%)
		ANK	82..196	CDD:238125	24/141 (17%)
		ANK repeat	83..110	CDD:293786	5/26 (19%)
		Ank_2	84..177	CDD:289560	18/126 (14%)
		ANK repeat	112..144	CDD:293786	6/46 (13%)
		ANK repeat	146..177	CDD:293786	6/49 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164088
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930