DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ckn and Inppl1

DIOPT Version :9

Sequence 1:	NP_611009.1	Gene:	ckn / 36673	FlyBaseID:	FBgn0033987	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001116211.1	Gene:	Inppl1 / 16332	MGIID:	1333787	Length:	1257	Species:	Mus musculus

Alignment Length:	369	Identity:	78/369 - (21%)
Similarity:	111/369 - (30%)	Gaps:	131/369 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKPHASTAQAKKVQPPTIPGDS---PQDLHLYQQPQQLHHHHHQHPNHHHPHHQPSI---PL--- 60
            ||...::.|.....||  |.:|   |....|...|.||           .|...||:   ||
Mouse   962 LKSEGTSEQEGVAAPP--PKNSFNNPAYYVLEGVPHQL-----------LPLEPPSLARAPLPPA 1013

  Fly    61 ------YRLSGP-LRHHQNHQADDGISMSGSSIVSSPSLEEGGFNLPRETSVALRLKDEVGGTST 118
                  ..:..| |..|:..:..:|   |.|...|..:|....|..|.....|:.|...:...|
Mouse  1014 TKNKVAITVPAPQLGRHRTPRVGEG---SSSDEDSGGTLPPPDFPPPPLPDSAIFLPPNLDPLS- 1074

  Fly   119 AAPTTGGPGGGGATVVGAPPPGAGKPGVAMVPPPPVFCATLREPLTHKAAVYYHQQLALQEDQGI 183
             .|...|..||.|.  |.|||.|.       |.||:
Mouse  1075 -MPVVRGRSGGEAR--GPPPPKAH-------PRPPL----------------------------- 1100

  Fly   184 DLTQSPGRDSPGSSSGSAGSGSRHSTASLDSGRASS---YLTGVSSSG--------------ASI 231
                .||.....:..|...||...|.:.|...:..|   |..|...|.              :..
Mouse  1101 ----PPGTSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPGPGRSALLPNPLELQPPRGPSDY 1161

  Fly   232 RAPLSSP----------------------RCSSVSSCSIGSVDRQRNDELIIDWLLEMKHEEYAQ 274
            ..|||.|                      |.|.:....:|:            ||..:..|.|.:
Mouse  1162 GRPLSFPPPRIRESIQEDLAEEAPCPQGGRASGLGEAGMGA------------WLRAIGLERYEE 1214

  Fly   275 LFIAAGY-DLPTIARMTPEDLTAIGIKNPHHRERIKQRIDKLQV 317
            ..:..|: ||..::.:|.|||...|:::|.|:..:   :|.||:
Mouse  1215 GLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLL---LDTLQL 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	17/65 (26%)
		SAM	260..316	CDD:197735	15/56 (27%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897
		SAM	326..387	CDD:197735
		Caskin-tail	<887..912	CDD:293238
Inppl1	NP_001116211.1	SH2_SHIP	17..119	CDD:198206
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..181
		INPP5c_SHIP2-INPPL1	425..728	CDD:197335
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..986		7/25 (28%)
		SH3-binding	945..950
		NPXY motif	984..987		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	999..1119		36/166 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1134..1196		9/61 (15%)
		SAM_Ship2	1193..1255	CDD:188890	18/76 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810