Protein Alignment ckn and Caskin1

DIOPT Version :10

• Sequence 1: NP_611009.1
• Gene: ckn / 36673
• FlyBaseID: FBgn0033987
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_006245957.1
• Gene: Caskin1 / 140722
• RGDID: 620191
• Length: 1437
• Species: Rattus norvegicus
• Alignment Length: 966
• Identity: 219/966 - (22%)
• Similarity: 346/966 - (35%)
• Gaps: 293/966 - (30%)

  Fly    45 QHPNHHHPHHQPSIPLYRLSGPLRHHQNHQADDGI----SMSGSSIV--------SSPSLEEGGF 97
            |||:.            |..|.:  |.|...:|.:    |..|.:||        |.||..:||.
  Rat   321 QHPDG------------RWKGCI--HDNRTGNDRVGYFPSSLGEAIVKRAGSRTGSEPSPPQGGG 371

  Fly    98 NL----PRETSVALRLKDEVGG--TSTAAPTTGGPGGGGATVVGAPPPGAGKPGVAMVPPPPVFC 156
            :|    |.|....|| |...||  :.:.:...||...||..:      .||..||.::
  Rat   372 SLGPSAPPEEIWVLR-KPFAGGDRSGSLSNVAGGRSTGGHAL------HAGAEGVKLL------- 422

  Fly   157 ATLREPLTHKAAVYYHQQLALQEDQGIDLTQSPGRDSPGSSSGSAGSGSRHSTASLDSGRASSYL 221
            ||:   |:.|                     |....|||.|......||        ||.|.|..
  Rat   423 ATV---LSQK---------------------SVSESSPGDSPVKPPEGS--------SGAARSQP 455

  Fly   222 TGVSSSGASIRAPLSSPRCSSVSSCSIGSVDRQRNDELIIDWLLEMKHEEYAQLFIAAGYDLPTI 286
            ....:.......|   |:....||.|.|     ::.|.:..||...:.:.||..|.:||||||||
  Rat   456 PAAHAGQVYGEQP---PKKLESSSASEG-----KSAEAVSQWLATFQLQLYAPNFTSAGYDLPTI 512

  Fly   287 ARMTPEDLTAIGIKNPHHRERIKQRIDKLQVLDNLPHFVPGSIEEWLQLLRLEEYIQPLLEQNYK 351
            :|||||||||||:..|.||::|...|..|.:.|.||...|.::..||.::.|.:|.:.|::..|:
  Rat   513 SRMTPEDLTAIGVTKPGHRKKITAEISGLNIPDCLPEHKPANLAVWLSMIGLAQYYKVLVDNGYE 577

  Fly   352 TVRDVTQVTWEDLEDIGIVKLGHQKKILLAIKRVKDIISGKWNPGGANAYQQQEYQRKPWQ---- 412
            .:..:|.:|||||::|||.|||||||::||::::.::...::     :.|:....:||..|
  Rat   578 NIDFITDITWEDLQEIGITKLGHQKKLMLAVRKLAELQKAEY-----SKYEGGPLRRKAPQSLEM 637

  Fly   413 --FNVPIPSTPSYV----PTTRVSWDDTKIYATSSVLNSTAPSGSSCLNSSLANGDAYYCTGSNH 471
              ...|.||.|:..    |......|........:.|:..|.:|::....|           |||
  Rat   638 MAIESPPPSEPAAAECQSPKMTTFQDSELSGELQAALSGPAEAGAAAAEKS-----------SNH 691

  Fly   472 ECCSGNDVVLIKVRQPRGKSLESLEDIHDNSTRSHLTFSHYTTTDYGHFGPPTTAAAAAAMAAAA 536
            ...:                                              |.||:...::::..|
  Rat   692 LPAT----------------------------------------------PRTTSRQESSLSGRA 710

  Fly   537 TLQQQHHHQQLLHQQQQQAAAARLLGNNAPGIGWRRSYDDGDITPTNDATRELLYEQEGGGTLPR 601
                           :..:::..|||:...|.|          :|.:.:...||.|....||.|:
  Rat   711 ---------------RHMSSSQELLGDGPQGPG----------SPMSRSQEYLLDEGPAPGTPPK 750

  Fly   602 QQRG-----ILQRAVLNTMPP------------LEHHHYMNAAAAAEYGAASGVEGGANYMGGSP 649
            :.|.     .::||   ::||            :.|.........|:.|:...: ||.:    .|
  Rat   751 EVRSSRHGHSVKRA---SVPPVPGKPRQVLPSGVSHFTPPQTPTKAQPGSPQAL-GGPH----GP 807

  Fly   650 LTGK-KIAPE--PPRRHCSIRNSRTLSGEGVPSGAAAQAHQQAAQQQQGQHMFYGHTAQHWQQQQ 711
            .|.| |..|:  ||       ..|.:|...:|              |...|..:.:...  |..:
  Rat   808 ATAKVKPTPQLLPP-------TDRPMSPRSLP--------------QSPTHRGFAYVLP--QPVE 849

  Fly   712 QQAG---AGTGQQPIYANYATI-QQTTAEIH----------CEKYHDSKSTSSIDSIDTIPFANE 762
            .:||   .|....|:.|...|: ....|::.          ..:|..|.|....|.: .:|.|..
  Rat   850 GEAGPPAPGPVPPPVPAAVPTLCLPPEADVEPGRPKKRAHSLNRYAASDSEPERDEL-LVPAAAG 913

  Fly   763 NTGTIKQRLLNRQELQGGGAGNNNV------------PGGGHPAHLHSSSSSSSSSSTNTIANIA 815
            ...|:::|:.....::.....:.||            .|...|....|||:.:|       ||:|
  Rat   914 PYATVQRRVGRSHSVRAPAGTDKNVNRSQSFAVRPRKKGPPPPPPKRSSSAMAS-------ANLA 971

  Fly   816 HSFHSLKSSSSLHDATLA------RSESMGSTASGGSALHLRS--PTLDMSNAGGS--------- 863
               ..........|..|.      |:..:..:...|||..::|  ..|::|:.||.
  Rat   972 ---DEPSPDVETEDGRLGVRAQRRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAIRRPPE 1033

  Fly   864 ---TAEPASSPEAAVPTVAINNGVPPKVSVNVLNDIGNMLANLTDELDAMLEEEKR 916
               |..|||.....|.||..:  |..|.::....::.|....|:..:..:|...:|
  Rat  1034 GHPTPRPASPDPGRVATVLAS--VKHKEAIGPDGEVVNRRRTLSGPVTGLLATARR 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	31/64 (48%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897	27/69 (39%)
		Caskin-tail	<887..912	CDD:465209	3/24 (13%)
Caskin1	XP_006245957.1	ANK repeat	260..294	CDD:293786
		SH3_Caskin1	291..352	CDD:212995	10/44 (23%)
		Caskin1-CID	380..428	CDD:465190	17/64 (27%)
		SAM_caskin1,2_repeat1	480..545	CDD:188896	32/69 (46%)
		SAM_caskin1,2_repeat2	547..616	CDD:188897	27/68 (40%)
		PTZ00449	<707..>835	CDD:185628	34/181 (19%)
		Caskin-Pro-rich	884..955	CDD:465308	11/71 (15%)
		PRK12323	<1224..>1413	CDD:481241
		Caskin-tail	1375..1437	CDD:465209
		Ank_2	7..86	CDD:463710
		ANK repeat	56..86	CDD:293786
		ANKYR	59..298	CDD:440430
		ANK repeat	88..119	CDD:293786
		ANK repeat	121..152	CDD:293786
		ANK repeat	154..193	CDD:293786
		ANK repeat	195..225	CDD:293786
		ANK repeat	228..258	CDD:293786