DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ckn and Caskin2

DIOPT Version :9

Sequence 1:NP_611009.1 Gene:ckn / 36673 FlyBaseID:FBgn0033987 Length:924 Species:Drosophila melanogaster
Sequence 2:NP_542374.2 Gene:Caskin2 / 140721 MGIID:2157062 Length:1201 Species:Mus musculus


Alignment Length:1002 Identity:223/1002 - (22%)
Similarity:323/1002 - (32%) Gaps:349/1002 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 GATVVGAPPPG--------AGKPGVAMVP--PPPVFCATLR-------EPLTHKAAVYYHQ--QL 175
            |...||..|||        .|.| ||.:|  |.|:..:..|       :||   .:|.|.|  ::
Mouse   330 GTDRVGYFPPGIVEVVSKRVGIP-VARLPSAPTPLRPSFSRISQPAADDPL---PSVPYGQLPRV 390

  Fly   176 ALQEDQGIDLTQSPGRDSPGSSSGSAGS-GSRHSTASLDSGRAS----SYLTGVSSSGA------ 229
            .|          ||  |||.....|.|| ||..|..|..||::|    .:.||:....|      
Mouse   391 GL----------SP--DSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGTGLLIENAQPLPSA 443

  Fly   230 -------SIRAP-----LSSPRCSSVSSCSIGSVD-------RQRNDELIIDWLLEMKHEEYAQL 275
                   .:.||     ||....:...|..|.:.|       ..::.:.|.:||.|.:.|.|...
Mouse   444 SEDQGLPGLHAPSPADNLSHRPLAGYRSGEIFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAH 508

  Fly   276 FIAAGYDLPTIARMTPEDLTAIGIKNPHHRERIKQRIDKLQVLDNLPHFVPGSIEEWLQLLRLEE 340
            |:.||||:|||:|||||||||||:..|.||::|...|.:|.:.:.||:::|..:.|||..|.|.:
Mouse   509 FLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPNYIPVDLLEWLCALGLPQ 573

  Fly   341 YIQPLLEQNYKTVRDVTQVTWEDLEDIGIVKLGHQKKILLAIKRVKDIISGKWNPGGANAYQQQE 405
            |.:.|:...|.::..|..:|||:|::||:.|||||||::|.:||:.::..|              
Mouse   574 YHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRG-------------- 624

  Fly   406 YQRKPWQFNVPIPSTPSYVPTTRVSWDDTKIYATSSVLNSTAPSGSSCLNSSLANGDAYYCTGSN 470
                                                                |.:|:|....|. 
Mouse   625 ----------------------------------------------------LLHGEALGEGGR- 636

  Fly   471 HECCSGNDVVLIKVRQPRGKSLESLEDIHDNSTRSHLTFSHYTTTDYGHFGPPTTAAAAAAMAAA 535
                          |..||..|.::|.: :|............|.......|...||.|...:..
Mouse   637 --------------RMTRGPELMAIEGL-ENGEGPTTAGPRLLTFQGSELSPELQAAMAGGGSEP 686

  Fly   536 ATLQQQHHHQQLLHQQQQQAAAARLLGNN--------APGIG-----WRRSYDDGDITPTNDAT- 586
            ..|..       .....|::..||..|:.        .|.:|     ..|:..:|...|:...: 
Mouse   687 LPLPP-------ARSPSQESIGARSRGSGHSQEQPVPQPSVGDPSAPQERNLPEGTERPSKLCSP 744

  Fly   587 -------------RELLYEQEGGGTLPRQQRGILQRAVLNTMP-----PLEHHHYMNAAAAAEYG 633
                         .:.|......|..|...|.....|.....|     |....|.::....||..
Mouse   745 LPGQGPAPYVFMCPQNLPSSPAPGPPPGVPRAFSYLAGSPAAPPDPPRPKRRSHSLSRPGPAEGE 809

  Fly   634 AASGVEGGANYMGGS---------------------PLTG-------------KKIAPEPPRRHC 664
            |....||......||                     |..|             |...|.||:|..
Mouse   810 AEGEAEGPVGSALGSYATLTRRPGRSTLARTSPSLTPTRGTPRSQSFALRARRKGPPPPPPKRLS 874

  Fly   665 SIRNSR---TLSGEGVPSGAAAQAHQQAAQQQQGQHMFYGHTAQHWQQQQQQAGAGTGQQPIYAN 726
            |:..|.   :|.|...|...|....::...:..|            ..:.....|.||       
Mouse   875 SVSGSTEPPSLDGTSGPKEGATGPRRRTLSEPTG------------PSESPGPSAPTG------- 920

  Fly   727 YATIQQTTAEIHCEKYHDSKSTSSIDSIDTIPFANENTGTIKQR--------------------- 770
              .:..|..|...|....|:.:|.    :.:|||.|...|||||                     
Mouse   921 --PVSDTEEEPGPEGTPPSRGSSG----EGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNL 979

  Fly   771 -----------LLNRQELQGG------------GAGN--------------NNVPGGGHPAHLHS 798
                       ...|:.||..            |..|              :|.|....|:.|.|
Mouse   980 TESDTVKRRPKCKEREPLQTALLAFGVVGSDTPGPSNPLSTQAPCDPPSASSNPPQRSEPSVLPS 1044

  Fly   799 SSSSSSSSSTNT-------------IANIAHSFHSLKSSSSLHDATLARSESMGST--------- 841
            ..:|:||.|:.|             :||...|..::::......|.|.:....|:.         
Mouse  1045 QGTSASSLSSVTQSPGHPGPSAGPALANSTGSKPNVETEPPAPPAALLKVPGAGTAPKPVSVACT 1109

  Fly   842 --ASGGSALHLR-----SPTLDMSNAG--------GSTAEPASSPEAAVPTVAINNGV-----PP 886
              |..|..|..|     .|.....|.|        ....:.:||.|||:.....:.|.     |.
Mouse  1110 QLAFSGPKLAPRLGPRPVPPPRPENTGPVCPGRAQQRLEQTSSSLEAALRAAEKSIGTEERDGPT 1174

  Fly   887 KVSV-NVLNDIGNMLANLTDELDAMLE 912
            ..|. ::|:||..|...|.|:|||||:
Mouse  1175 GTSTKHILDDISTMFDALADQLDAMLD 1201

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cknNP_611009.1 SAM_caskin1,2_repeat1 254..319 CDD:188896 31/64 (48%)
SAM 260..316 CDD:197735 30/55 (55%)
SAM_caskin1,2_repeat2 320..390 CDD:188897 28/69 (41%)
SAM 326..387 CDD:197735 26/60 (43%)
Caskin-tail <887..912 CDD:293238 11/25 (44%)
Caskin2NP_542374.2 ANK 7..135 CDD:238125
Ank_4 7..61 CDD:290365
ANK repeat 7..46 CDD:293786
ANK repeat 48..79 CDD:293786
ANK 1 48..77
Ank_2 53..145 CDD:289560
ANK 76..209 CDD:238125
ANK 2 81..110
ANK repeat 85..112 CDD:293786
ANK repeat 114..145 CDD:293786
ANK 3 114..143
ANK 4 147..176
Ank_2 152..251 CDD:289560
ANK repeat 158..219 CDD:293786
ANK 183..311 CDD:238125
ANK 5 188..217
ANK 6 220..249
ANK repeat 221..251 CDD:293786
SH3_Caskin2 284..345 CDD:212996 6/14 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 355..466 32/125 (26%)
SAM_caskin1,2_repeat1 487..552 CDD:188896 31/64 (48%)
SAM 493..548 CDD:197735 30/54 (56%)
SAM_caskin1,2_repeat2 553..623 CDD:188897 28/69 (41%)
SAM 561..620 CDD:197735 25/58 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..1103 80/459 (17%)
Caskin-Pro-rich 797..881 CDD:293512 17/83 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1115..1179 14/63 (22%)
Caskin-tail 1144..1201 CDD:293238 18/56 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 67 1.000 Domainoid score I9778
eggNOG 1 0.900 - - E1_KOG4384
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002692
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
65.770

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