DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ckn and caskin2

DIOPT Version :9

Sequence 1:	NP_611009.1	Gene:	ckn / 36673	FlyBaseID:	FBgn0033987	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_004918519.2	Gene:	caskin2 / 100487214	XenbaseID:	XB-GENE-1008062	Length:	1208	Species:	Xenopus tropicalis

Alignment Length:	1074	Identity:	245/1074 - (22%)
Similarity:	370/1074 - (34%)	Gaps:	342/1074 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LRHHQNHQADDGISMSGSSIVSSPSLEEGGFNLPRETSVALRLKDEVGGTSTAAPTTGGPGGGG- 130
            :|:..|..|.|.::...::..|:...:     |.||.|..|:::......:...||......|.
Frog   249 IRNTYNQTALDIVNQFTTTHASTDIKQ-----LLREASGILKVRALKDFWNAHDPTALNVRAGDL 308

  Fly   131 ATVVGAPPPG----------AGKPGVAMVPPP--PVFCATLREPLTHKAAVYYHQQLALQEDQGI 183
            .||:...|.|          .|...|...||.  .|....|...|:....|..||:||...
Frog   309 ITVLEQHPDGRWKGHIHDLQKGTDRVGFFPPSIVEVISKRLGSTLSRNITVPSHQRLAKSA---- 369

  Fly   184 DLTQSPGRDSP--GSSSG----SAGSGSRHSTASLDSGRASSYLTGVSSSGASIRAPLSSPRC-- 240
             || .|.:.||  ||..|    ::.:|.|||..|..|.|::.  :|.|..|..|...|.....
Frog   370 -LT-LPIQHSPITGSQLGINPETSVAGDRHSVGSESSIRSAG--SGQSCEGQLINTALLIENAQT 430

  Fly   241 -----SSVSSC-------------SIGSVDRQ-------RNDELIIDWLLEMKHEEYAQLFIAAG 280
                 .::.:|             :|.||::.       ::.|.|..||...:.|.|.:.||:||
Frog   431 MHFGSENLQNCQTFPGPVSGHLLSTILSVEKDPGVYLQGKDAEQIYCWLRSFQMESYVENFISAG 495

  Fly   281 YDLPTIARMTPEDLTAIGIKNPHHRERIKQRIDKLQVLDNLPHFVPGSIEEWLQLLRLEEYIQPL 345
            ||||||.|:|||||||||:..|.||::|...|.||.|.|.||...|..:.:||..|.|.||.:.|
Frog   496 YDLPTIMRVTPEDLTAIGVTKPGHRKKISTEIGKLIVADGLPQQTPVDLWDWLSQLGLPEYHKQL 560

  Fly   346 LEQNYKTVRDVTQVTWEDLEDIGIVKLGHQKKILLAIKRVKDIISGKWNPGGANAYQQQEYQRK- 409
            .|..|:::..||::|||.|::|||.:||||||:||.:||:.|:..| :..||.       .:|:
Frog   561 SENGYESLSTVTELTWEGLQEIGIHRLGHQKKLLLGVKRLTDLQKG-YPIGGT-------LRRRI 617

  Fly   410 -PWQFNVPIPSTPSYVPTTRVSWDDTKIYATSSVLNSTAPSGSSCLNSSLANGDAYYCTGSNHEC 473
             ..|..|.:..:|          ::..:..|..:|.......|..|.|:|..|:...|||.
Frog   618 LGSQDTVALVESP----------ENGDLPVTPKLLTFQGGELSRELQSALTRGNEPLCTGR---- 668

  Fly   474 CSGNDVVLIKVRQPRGKSLESLEDIHDNSTRSHLTFSHYTTTDYGHFGPPTTAAAAAAMAAAATL 538
                          |..|.||:......|..|..:.:.:..       ||     .........|
Frog   669 --------------RSFSQESISSRSQGSGHSQESATSFPV-------PP-----VPPQGVELNL 707

  Fly   539 QQQHH---HQQLLHQQQ----------------QQAAAARLLGNNAPGIGWRRSYDDGDITPTND 584
            .|::|   .:|.||..:                :.|...|.|.      ..|.:..||:    .|
Frog   708 PQRNHPEGTEQTLHHHRVPNGCLIQPEPPAPPPKPALKKRSLS------ACRYALSDGE----PD 762

  Fly   585 ATRELLYEQEGGGTLPRQQRGILQRAVLNTMPPLEHHHYMNAAAAAEYGAASGVEGGANYMGGSP 649
            ...|......|.|||.       ..|.|...|                |..|...|...
Frog   763 EEEEKKMATSGTGTLS-------SYATLTRRP----------------GRCSLTNGQLE------ 798

  Fly   650 LTGKKI---------------APEPPRRHCSIRNSRTLSGEGVPSGAAAQAHQQAAQQQQGQHMF 699
               ||:               .|.||:|..|:.     |.|| ||.....:.:..|.|.:.....
Frog   799 ---KKVQRSQSFAVRARRKGPPPPPPKRLSSMS-----SVEG-PSPEVQSSVRTIAAQLEDLSKG 854

  Fly   700 YGHTAQHWQQQQQQA--GAGTGQQPIYANYA------TIQQTTAEIHCEKYHDSKSTSSIDSIDT 756
            .|.:|...:....:.  .:||.::.:..:.|      ::...|.::..|:..:...:|...|.::
Frog   855 AGFSASTSKASHTEVLESSGTRRRTVSESAAGLGGRLSLPLATKKVEEEERKEEPISSQHSSSES 919

  Fly   757 IPFANENTGTIKQRLLNRQELQGGGAGNNNVPGGGHP----------AHLHSSSSS--------- 802
            ||||.|...|||||     ....|......||....|          ..|||.:||
Frog   920 IPFAEEGNLTIKQR-----PKPPGAKLEQEVPSELSPTLDSQLPSSETQLHSEASSILAKPVSVA 979

  Fly   803 ----------------------SSSSSTNTIANIAHSFHSLKSSSSLHDATL-ARSESMGSTASG 844
                                  .:.::.:|..|:.|.|:..:|.:......| .:.|.....|..
Frog   980 PPQARPQIAAKPQIGPKPDTGVRAPTAASTPKNVEHDFNLTESDTVKRRPKLKEKEEESPKAAME 1044

  Fly   845 GSALHLRSP----TLD----------------------MSNAGGSTAE----------------- 866
            .|:|.|..|    |.|                      :...|.||..
Frog  1045 NSSLSLFPPQEPLTQDTLTTKIADIDKRLLSLEVREDPVKKTGISTRSTGVSISQTHLVISGPQQ 1109

  Fly   867 --------------PASS------------PEAAVP--TVAINNGVPP----------------- 886
                          ||.|            ....:|  :::|::..||
Frog  1110 VLQKPSKAVTGPLLPAGSILWDRESVALSRERTCIPQQSISISDKGPPVLTNPLQNTEEPQDNRE 1174

  Fly   887 --------KVSVNVLNDIGNMLANLTDELDAMLE 912
                    :::.|:|:||..|..:|.::|:|||:
Frog  1175 KSCSRENVQLTKNILDDISTMFDDLAEQLEAMLD 1208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckn	NP_611009.1	SAM_caskin1,2_repeat1	254..319	CDD:188896	34/71 (48%)
		SAM	260..316	CDD:197735	31/55 (56%)
		SAM_caskin1,2_repeat2	320..390	CDD:188897	32/69 (46%)
		SAM	326..387	CDD:197735	29/60 (48%)
		Caskin-tail	<887..912	CDD:293238	9/24 (38%)
caskin2	XP_004918519.2	Ank_4	7..69	CDD:372654
		ANK repeat	7..46	CDD:293786
		PHA02875	40..>279	CDD:165206	6/34 (18%)
		ANK repeat	48..79	CDD:293786
		ANK repeat	81..112	CDD:293786
		ANK repeat	114..145	CDD:293786
		ANK repeat	150..186	CDD:293786
		Ank_2	152..251	CDD:403870	0/1 (0%)
		ANK repeat	188..219	CDD:293786
		ANK repeat	221..251	CDD:293786	0/1 (0%)
		SH3_Caskin2	284..345	CDD:212996	12/60 (20%)
		SAM_caskin1,2_repeat1	469..534	CDD:188896	34/64 (53%)
		SAM_caskin1,2_repeat2	535..605	CDD:188897	32/69 (46%)
		Caskin-Pro-rich	747..831	CDD:407141	25/130 (19%)
		FtsN	<932..>1010	CDD:225629	11/82 (13%)
		Caskin-tail	<1175..1208	CDD:406925	9/32 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9482
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002692
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910