DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lap1 and CYR1

DIOPT Version :9

Sequence 1:NP_001188938.1 Gene:Lap1 / 36670 FlyBaseID:FBgn0033984 Length:849 Species:Drosophila melanogaster
Sequence 2:NP_012529.3 Gene:CYR1 / 853452 SGDID:S000003542 Length:2026 Species:Saccharomyces cerevisiae


Alignment Length:1050 Identity:222/1050 - (21%)
Similarity:349/1050 - (33%) Gaps:327/1050 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 PCFKFKREEVIDKLDYSNT-----PL-------------------TDFPEVWQHERTLEELYLST 49
            |...::....|:.||.||.     ||                   :.||........|..|.|..
Yeast   808 PIIFYQHTSEIESLDVSNNANIFLPLEFIESSIKLLSLRMVNIRASKFPSNITKAYKLVSLELQR 872

  Fly    50 TRLQALPPQLFYCQGLRVLHVNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHL 114
            ..::.:|..:.....|.:|::..|.|||:|.....|:.||.|||:.|..::.||.|..|.:|..:
Yeast   873 NFIRKVPNSIMKLSNLTILNLQCNELESLPAGFVELKNLQLLDLSSNKFMHYPEVINYCTNLLQI 937

  Fly   115 DLSCNSLQRLPDAITSLISLQELLLNETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLIN 179
            |||.|.:|.||.:...|:.|.::.|:...|.|: .:...:.:||.|.||.|.:.::   .....|
Yeast   938 DLSYNKIQSLPQSTKYLVKLAKMNLSHNKLNFI-GDLSEMTDLRTLNLRYNRISSI---KTNASN 998

  Fly   180 LQRLDIGGNEFTELPEVVGELKSLRELWIDFNQIRRVSAN------------------------I 220
            ||.|.:..|..:...:.   |..||.|.|..|.|..:|..                        :
Yeast   999 LQNLFLTDNRISNFEDT---LPKLRALEIQENPITSISFKDFYPKNMTSLTLNKAQLSSIPGELL 1060

  Fly   221 GKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAFPFSVGMLKSLVTFKCESNGLTEL 285
            .||..|:..|.|.|.|..||.|:|....:..||:..|.||..|..:..||||.|....||.:.:.
Yeast  1061 TKLSFLEKLELNQNNLTRLPQEISKLTKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNIRDF 1125

  Fly   286 PD--------------------------------------------------------------- 287
            .|                                                               
Yeast  1126 VDGMENLELTSLNISSNAFGNSSLENSFYHNMSYGSKLSKSLMFFIAADNQFDDAMWPLFNCFVN 1190

  Fly   288 ----SISY----------LEQLEELVLSHNKLIRLP-STIGMLRSLRFLFADDNQLRQLPDELCS 337
                ::||          ||.:.||.||.|||..|. .|:....||:.|..:.||:..||.||.:
Yeast  1191 LKVLNLSYNNFSDVSHMKLESITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAELSN 1255

  Fly   338 CQQLSVLSVANNQLSALPQNIGNL---------SKMKVLNVVNNY------------------IN 375
            ..||||..|..|||.   .||.|.         .::|.||...|.                  :.
Yeast  1256 LSQLSVFDVGANQLK---YNISNYHYDWNWRNNKELKYLNFSGNRRFEIKSFISHDIDADLSDLT 1317

  Fly   376 ALPVSMLNLVNLTSMWLSDNQSQPLVPLQYLDASTKTQLTCFMLPQVTFKMNSIQAQQQAQEQYE 440
            .||  .|.::.|..:.|:..:    ||.:.::...:|  |..::..:.:.:    |....|..| 
Yeast  1318 VLP--QLKVLGLMDVTLNTTK----VPDENVNFRLRT--TASIINGMRYGV----ADTLGQRDY- 1369

  Fly   441 FVYANQQQPHASPSRRICFA------EEATI-LSNAKAQPAPNYPSFVAAPPTPTPDQMAGSVRL 498
                       ..||.:.|.      :|..: |.::|.|.| :|...::              |:
Yeast  1370 -----------VSSRDVTFERFRGNDDECLLCLHDSKNQNA-DYGHNIS--------------RI 1408

  Fly   499 MRSPTPYPKEL-RQMSKYVRQAQAATSSANASEVREARVVTNGQIHCDSNNANQDVVDQATTSAI 562
            :|.  .|.|.| ||:.:|..:......:|......:.....||.::...|.|  ||.:.:....:
Yeast  1409 VRD--IYDKILIRQLERYGDETDDNIKTALRFSFLQLNKEINGMLNSVDNGA--DVANLSYADLL 1469

  Fly   563 YGIAPETTHIYGVYQQPQQMAHPVPTQEYYGLPLVNYEAHYQQLYVEANTPLPTTHLNGDQDYEL 627
            .|......:|.|              ::.:...|.:..|     .:..|        |||     
Yeast  1470 SGACSTVIYIRG--------------KKLFAANLGDCMA-----ILSKN--------NGD----- 1502

  Fly   628 QPLQQQPMQQQALPTPRLE-------------------------------PPPYH----IARVYT 657
                .|.:.:|.|||.|.|                               .|..|    |:.|..
Yeast  1503 ----YQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLLPHIHASPDISVVTL 1563

  Fly   658 KKTPEDL-----NLYESMRQRKQQQQLQEQTIYQDALNSNSNFKTTAIGAQDVEESV-------- 709
            .|..|.|     .|:|.|.........:|.:  .|.|.:.:..|..|: |....|::        
Yeast  1564 TKADEMLIVATHKLWEYMDVDTVCDIARENS--TDPLRAAAELKDHAM-AYGCTENITILCLALY 1625

  Fly   710 DQLDYQNNISNNLEPNPEEEDQELDDTMSQHSLN-STATNNTSK--ASHKKSTWIFGVHKNPTVK 771
            :.:..||..:.|............|.|:.:.... |..|.|.:.  ...|.||:::.:.  |...
Yeast  1626 ENIQQQNRFTLNKNSLMTRRSTFEDTTLRRLQPEISPPTGNLAMVFTDIKSSTFLWELF--PNAM 1688

  Fly   772 QVTLKWENSI---------GFDIAELLNQVGIFVSSITPNTNAARLLNLNDKLLEI--------- 818
            :..:|..|.|         |:::.  .......|:..||.:.....|::..|||:.         
Yeast  1689 RTAIKTHNDIMRRQLRIYGGYEVK--TEGDAFMVAFPTPTSGLTWCLSVQLKLLDAQWPEEITSV 1751

  Fly   819 -DGYDLTNAN 827
             ||..:|:.|
Yeast  1752 QDGCQVTDRN 1761

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lap1NP_001188938.1 LRR_RI <21..200 CDD:238064 54/202 (27%)
leucine-rich repeat 21..41 CDD:275380 8/43 (19%)
LRR_8 40..98 CDD:290566 18/57 (32%)
leucine-rich repeat 42..64 CDD:275380 4/21 (19%)
leucine-rich repeat 65..87 CDD:275380 8/21 (38%)
LRR_8 86..140 CDD:290566 20/53 (38%)
leucine-rich repeat 88..110 CDD:275380 10/21 (48%)
leucine-rich repeat 111..133 CDD:275380 9/21 (43%)
leucine-rich repeat 134..156 CDD:275380 4/21 (19%)
LRR_8 156..213 CDD:290566 17/56 (30%)
leucine-rich repeat 157..179 CDD:275380 6/21 (29%)
leucine-rich repeat 180..202 CDD:275380 5/21 (24%)
leucine-rich repeat 203..225 CDD:275380 9/45 (20%)
leucine-rich repeat 226..248 CDD:275380 9/21 (43%)
leucine-rich repeat 272..294 CDD:275380 8/98 (8%)
LRR_8 279..328 CDD:290566 20/126 (16%)
leucine-rich repeat 295..317 CDD:275380 9/22 (41%)
leucine-rich repeat 318..340 CDD:275380 8/21 (38%)
LRR_8 340..396 CDD:290566 20/82 (24%)
leucine-rich repeat 364..386 CDD:275380 7/39 (18%)
PDZ_signaling 770..846 CDD:238492 14/76 (18%)
CYR1NP_012529.3 Ad_cyc_g-alpha 368..418 CDD:369912
RA_PHLPP_like 678..776 CDD:340473
PLN00113 792..>1273 CDD:215061 119/474 (25%)
leucine-rich repeat 796..817 CDD:275380 1/8 (13%)
leucine-rich repeat 818..839 CDD:275380 7/20 (35%)
leucine-rich repeat 840..864 CDD:275380 2/23 (9%)
leucine-rich repeat 865..887 CDD:275380 4/21 (19%)
leucine-rich repeat 888..910 CDD:275380 8/21 (38%)
leucine-rich repeat 911..933 CDD:275380 10/21 (48%)
leucine-rich repeat 934..956 CDD:275380 9/21 (43%)
leucine-rich repeat 957..978 CDD:275380 4/21 (19%)
leucine-rich repeat 979..1018 CDD:275380 12/44 (27%)
leucine-rich repeat 1019..1041 CDD:275380 7/21 (33%)
leucine-rich repeat 1042..1065 CDD:275380 2/22 (9%)
leucine-rich repeat 1066..1088 CDD:275380 9/21 (43%)
leucine-rich repeat 1089..1111 CDD:275380 7/21 (33%)
leucine-rich repeat 1167..1187 CDD:275380 0/19 (0%)
leucine-rich repeat 1191..1211 CDD:275380 3/19 (16%)
leucine-rich repeat 1236..1258 CDD:275380 8/21 (38%)
leucine-rich repeat 1259..1287 CDD:275380 10/30 (33%)
PP2C 1374..1617 CDD:395385 55/300 (18%)
CYCc 1613..1825 CDD:214485 27/152 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm46761
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.