DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lap1 and PIRL9

DIOPT Version :9

Sequence 1:	NP_001188938.1	Gene:	Lap1 / 36670	FlyBaseID:	FBgn0033984	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_187741.2	Gene:	PIRL9 / 820306	AraportID:	AT3G11330	Length:	499	Species:	Arabidopsis thaliana

Alignment Length:	323	Identity:	100/323 - (30%)
Similarity:	146/323 - (45%)	Gaps:	84/323 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EEVIDKLDYSNTPLTDFPEVWQHERTLEELYLSTTRLQALPPQLFYCQGLRVLHVNSNNLESIPQ 80
            |||:..|.:::.            ..::.:.||..:|:.||......|||.||::::|.|||||.
plant   186 EEVVGILQHASA------------NPVDRVDLSGRKLRLLPEAFGRIQGLLVLNLSNNKLESIPD 238

  Fly    81 AIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITSLISLQELLLNETYLE 145
            :|..|..                       |..||:|.|||:.|||:|
plant   239 SIAGLHS-----------------------LVELDVSTNSLETLPDSI----------------- 263

  Fly   146 FLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPEVVG-ELKSLRELWID 209
                  |.|..|:||.:..|.|.:||.|:.|..:|..||:..|..|.||..:| ||.:|.:|.:.
plant   264 ------GLLSKLKILNVSTNKLTSLPDSICRCGSLVILDVSFNRLTYLPTNIGPELVNLEKLLVQ 322

  Fly   210 FNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSN--SLEAFPFSVGMLKSL 272
            :|:||....:||::|.|:|.:|:.|.|:.||.......|:|.|::.||  .|:..|||.|.|.|
plant   323 YNKIRSFPTSIGEMRSLKHLDAHFNELNGLPDSFVLLTNLEYLNLSSNFSDLKDLPFSFGELIS- 386

  Fly   273 VTFKCESNGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLFADDNQLRQLPDEL 335
                                  |:||.||:|::..||.|.|.|.||..|..|.|.|...|:|:
plant   387 ----------------------LQELDLSNNQIHALPDTFGTLDSLTKLNVDQNPLVVPPEEV 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_001188938.1	LRR_RI	<21..200	CDD:238064	49/179 (27%)
		leucine-rich repeat	21..41	CDD:275380	1/19 (5%)
		LRR_8	40..98	CDD:290566	18/57 (32%)
		leucine-rich repeat	42..64	CDD:275380	5/21 (24%)
		leucine-rich repeat	65..87	CDD:275380	11/21 (52%)
		LRR_8	86..140	CDD:290566	11/53 (21%)
		leucine-rich repeat	88..110	CDD:275380	0/21 (0%)
		leucine-rich repeat	111..133	CDD:275380	11/21 (52%)
		leucine-rich repeat	134..156	CDD:275380	2/21 (10%)
		LRR_8	156..213	CDD:290566	22/57 (39%)
		leucine-rich repeat	157..179	CDD:275380	9/21 (43%)
		leucine-rich repeat	180..202	CDD:275380	10/22 (45%)
		leucine-rich repeat	203..225	CDD:275380	7/21 (33%)
		leucine-rich repeat	226..248	CDD:275380	7/21 (33%)
		leucine-rich repeat	272..294	CDD:275380	0/21 (0%)
		LRR_8	279..328	CDD:290566	16/48 (33%)
		leucine-rich repeat	295..317	CDD:275380	11/21 (52%)
		leucine-rich repeat	318..340	CDD:275380	7/18 (39%)
		LRR_8	340..396	CDD:290566
		leucine-rich repeat	364..386	CDD:275380
		PDZ_signaling	770..846	CDD:238492
PIRL9	NP_187741.2	leucine-rich repeat	202..222	CDD:275380	5/19 (26%)
		LRR_RI	205..397	CDD:238064	83/260 (32%)
		LRR_8	222..279	CDD:290566	29/102 (28%)
		leucine-rich repeat	223..245	CDD:275380	11/21 (52%)
		leucine-rich repeat	246..268	CDD:275380	13/44 (30%)
		leucine-rich repeat	269..291	CDD:275380	9/21 (43%)
		leucine-rich repeat	292..315	CDD:275380	10/22 (45%)
		LRR_8	315..370	CDD:290566	18/54 (33%)
		leucine-rich repeat	316..338	CDD:275380	7/21 (33%)
		leucine-rich repeat	339..361	CDD:275380	7/21 (33%)
		LRR_8	360..420	CDD:290566	28/82 (34%)
		leucine-rich repeat	362..386	CDD:275380	10/23 (43%)
		leucine-rich repeat	387..409	CDD:275380	11/21 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3538
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910