DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lap1 and SHOC2

DIOPT Version :9

Sequence 1:NP_001188938.1 Gene:Lap1 / 36670 FlyBaseID:FBgn0033984 Length:849 Species:Drosophila melanogaster
Sequence 2:NP_001311265.1 Gene:SHOC2 / 8036 HGNCID:15454 Length:582 Species:Homo sapiens


Alignment Length:450 Identity:130/450 - (28%)
Similarity:211/450 - (46%) Gaps:56/450 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LSKCFPCFKFKREEVIDKLDYSNTPLTDFPEVWQHERTLEELYLSTTRLQALPPQLFYCQGLRVL 68
            |:||       |||...:||.|...:...|...:....|.||||.:.:||:||.::.....|..|
Human    94 LNKC-------REENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTL 151

  Fly    69 HVNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITSLIS 133
            .::.|:|.|:|.::.:|::|:.|||..|.:..:|..:.....||.|.|..|.:..:...|.:|..
Human   152 ALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSK 216

  Fly   134 LQELLLNETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPEVVG 198
            |..|.:.|..::.|||..|.|.||..|::..|.|..|||.:.....:..||:..||..:||:.:|
Human   217 LSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIG 281

  Fly   199 ELKSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSEL-------------------- 243
            .|.||..|.:.:|::..:..::.|...|:......|.:.|||..|                    
Human   282 NLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLY 346

  Fly   244 -----------------------------SNWRNVEVLSICSNSLEAFPFSVGMLKSLVTFKCES 279
                                         |..:.:..|::..|.|.:.|...|...|:|.....:
Human   347 PVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLAT 411

  Fly   280 NGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLFADDNQLRQLPDELCSCQQLSVL 344
            |.||::|:.:|.|..||.|:||:|.|.:||..:|.||.||.|..::|:|..||:|:...:.|..|
Human   412 NQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKL 476

  Fly   345 SVANNQLSALPQNIGNLSKMKVLNVVNNYINALPVSMLNLVNLTSMWLSDNQSQPLVPLQ 404
            .:.||||:.||:.||:|:.:..|.:..|.:..||..:..|.||..::|:||.:...:|.:
Human   477 VLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFE 536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lap1NP_001188938.1 LRR_RI <21..200 CDD:238064 56/178 (31%)
leucine-rich repeat 21..41 CDD:275380 4/19 (21%)
LRR_8 40..98 CDD:290566 21/57 (37%)
leucine-rich repeat 42..64 CDD:275380 9/21 (43%)
leucine-rich repeat 65..87 CDD:275380 7/21 (33%)
LRR_8 86..140 CDD:290566 15/53 (28%)
leucine-rich repeat 88..110 CDD:275380 6/21 (29%)
leucine-rich repeat 111..133 CDD:275380 7/21 (33%)
leucine-rich repeat 134..156 CDD:275380 8/21 (38%)
LRR_8 156..213 CDD:290566 20/56 (36%)
leucine-rich repeat 157..179 CDD:275380 7/21 (33%)
leucine-rich repeat 180..202 CDD:275380 8/21 (38%)
leucine-rich repeat 203..225 CDD:275380 4/21 (19%)
leucine-rich repeat 226..248 CDD:275380 7/70 (10%)
leucine-rich repeat 272..294 CDD:275380 7/21 (33%)
LRR_8 279..328 CDD:290566 22/48 (46%)
leucine-rich repeat 295..317 CDD:275380 11/21 (52%)
leucine-rich repeat 318..340 CDD:275380 8/21 (38%)
LRR_8 340..396 CDD:290566 20/55 (36%)
leucine-rich repeat 364..386 CDD:275380 5/21 (24%)
PDZ_signaling 770..846 CDD:238492
SHOC2NP_001311265.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..88
LRR 1 101..122 4/20 (20%)
leucine-rich repeat 104..124 CDD:275380 4/19 (21%)
PLN00113 <115..>483 CDD:215061 103/367 (28%)
LRR 2 124..145 9/20 (45%)
leucine-rich repeat 125..147 CDD:275380 9/21 (43%)
LRR 3 147..169 6/21 (29%)
leucine-rich repeat 148..170 CDD:275380 7/21 (33%)
LRR 4 170..191 6/20 (30%)
leucine-rich repeat 171..193 CDD:275380 6/21 (29%)
LRR 5 193..214 6/20 (30%)
leucine-rich repeat 194..216 CDD:275380 7/21 (33%)
LRR 6 216..237 7/20 (35%)
leucine-rich repeat 217..239 CDD:275380 8/21 (38%)
LRR 7 239..260 8/20 (40%)
leucine-rich repeat 240..262 CDD:275380 7/21 (33%)
LRR 8 262..283 7/20 (35%)
leucine-rich repeat 263..285 CDD:275380 8/21 (38%)
LRR 9 285..307 5/21 (24%)
leucine-rich repeat 286..332 CDD:275380 10/45 (22%)
LRR 10 308..329 6/20 (30%)
LRR 11 332..353 0/20 (0%)
leucine-rich repeat 333..380 CDD:275380 1/46 (2%)
LRR 12 356..377 0/20 (0%)
LRR 13 380..400 4/19 (21%)
leucine-rich repeat 381..403 CDD:275380 5/21 (24%)
LRR 14 403..424 7/20 (35%)
leucine-rich repeat 404..426 CDD:275380 7/21 (33%)
LRR 15 426..448 10/21 (48%)
leucine-rich repeat 427..449 CDD:275380 11/21 (52%)
LRR 16 449..470 8/20 (40%)
leucine-rich repeat 450..472 CDD:275380 8/21 (38%)
PLN03150 <453..527 CDD:178695 25/73 (34%)
LRR 17 472..494 10/21 (48%)
leucine-rich repeat 473..495 CDD:275380 11/21 (52%)
LRR 18 495..516 4/20 (20%)
leucine-rich repeat 496..519 CDD:275380 5/22 (23%)
LRR 19 518..540 6/18 (33%)
LRR 20 542..563
leucine-rich repeat 543..563 CDD:275380
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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