DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lap1 and lrrc7

DIOPT Version :9

Sequence 1:	NP_001188938.1	Gene:	Lap1 / 36670	FlyBaseID:	FBgn0033984	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	XP_005166019.1	Gene:	lrrc7 / 566023	ZFINID:	ZDB-GENE-130530-876	Length:	1556	Species:	Danio rerio

Alignment Length:	797	Identity:	257/797 - (32%)
Similarity:	395/797 - (49%)	Gaps:	179/797 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLSKCFPCFKFK-REEVIDKLDYSNTPLTDFP-EVWQHERTLEELYLSTTRLQALPPQLFYCQGL 65
            ::.:..||..|: .||||..||||:..|...| |::..|||||||||...:::.||.|||.||.|
Zfish    20 IIGRLVPCRCFRGEEEVISVLDYSHCSLQQVPKEIFSFERTLEELYLDANQIEELPKQLFNCQAL 84

  Fly    66 RVLHVNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITS 130
            :.|.:..|:|.::|..|.||..|:.||:::|.|...|:.||.||.|:.::.|.|.:.:||:..|.
Zfish    85 KKLSMPDNDLSNLPTTIASLVNLKELDISKNGIQEFPDNIKCCKCLSVVEASVNPIAKLPEGFTQ 149

  Fly   131 LISLQELLLNETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPE 195
            |::|.:|.||:.:||:||||||||..|||||||.|:|.|:|||:.||..|:|||:|.|||:||||
Zfish   150 LLNLTQLFLNDAFLEYLPANFGRLSKLRILELRENHLKTMPKSIHRLSQLERLDLGSNEFSELPE 214

  Fly   196 VVGELKSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLE 260
            |:.::.||:|||:|.|.::.:..:|||||.|::.:...|.:::|.:::|...::|.|.:.:|.|:
Zfish   215 VLEQIHSLKELWLDNNSLQTIPGSIGKLRQLRYLDLAKNRIESLDADISGCESLEDLLLSANMLQ 279

  Fly   261 AFPFSVGMLKSLVTFKCESNGLTELPDSISY------LEQLEELVLSHNKLIRLPSTIGMLRSLR 319
            ..|.|:|.||.|.|.|.:.|.||.||::|..      |..|||...|.|:|..||.|||.|.|||
Zfish   280 QLPDSIGKLKKLTTLKVDDNQLTSLPNTIGSAHGKFGLSLLEEFDCSCNELESLPPTIGYLHSLR 344

  Fly   320 FLFADDNQLRQLPDELCSCQQLSVLSVANNQLSALPQNIGNLSKMKVLNVVNNYINALPVSMLNL 384
            ...||:|.|..||.|:.:|:.::|:|:.:|:|..||..||.::|::|||:.:|.:..||.:...|
Zfish   345 TFAADENFLSDLPREIGNCRNVTVMSLRSNKLEFLPDEIGQMTKLRVLNLSDNRLKNLPFTFTKL 409

  Fly   385 VNLTSMWLSDNQSQPLVPLQYLDASTKTQ---LTCFMLPQVTFKMNSIQAQQQAQEQYE------ 440
            .:|.::|||||||:.|:||| .:|..:|:   ||.:|.||          |.:..|.|:
Zfish   410 KDLAALWLSDNQSKALIPLQ-TEAHPETKQRVLTNYMFPQ----------QPRHDEDYQSDTDSF 463

  Fly   441 --FVYANQQQPHASPSRRICFAEEATILSNAKAQPAPNYPSFVAAPPTPTPDQMAGSVR----LM 499
              .::..|:|      :|:..|.|   ..:.|.:                 :..:|.|:    |.
Zfish   464 NPTLWEEQRQ------QRMTVAFE---FEDKKEE-----------------EDNSGKVKVEINLK 502

  Fly   500 RSPTPYPKELRQMSKYVRQAQAATSSANASEVREARVVTNGQIHCDSNNANQDVVDQATTSAIYG 564
            |.|||||::|:.|.|.|                                  |::|.:.|
Zfish   503 RYPTPYPEDLKNMVKSV----------------------------------QNLVGKTT------ 527

  Fly   565 IAPETTHIYGVYQQPQQMAHPVPTQEYYGLPLVNYEAHYQQLYVEANTPL-PTTHLNGD-QDYEL 627
                               ||:.|::...  ..|.|.|.|..| |...|: |......| :||..
Zfish   528 -------------------HPLNTEKCSS--GTNMELHSQDKY-EPKWPIAPKEVTERDVKDYSN 570

  Fly   628 QPLQQQ-PMQQQALPTPR-----LEPPPYHIARVYTK-KTPEDLNLYES---------------- 669
            ||:..| .:...|:..|:     .|.....:.||..| :.||:.:|..|
Zfish   571 QPMSDQGVILNSAIDIPKRKEDLTESSEISLHRVVPKPQQPENTSLAVSSSSCFCLIDSMGGSPN 635

  Fly   670 -MRQRKQQQQLQEQTIYQDALNSNSNFKTTAIGAQDVEESVDQLDYQNNISNNLEPNPEEEDQEL 733
             :|....:..|.|..:|:.        |...:| ::.:||.|            |..|::
Zfish   636 DIRISDMRPTLVEPPMYKP--------KVVLLG-KEKKESTD------------ESEPDK----- 674

  Fly   734 DDTMSQHSLNSTATNNT 750
                 .|.||::.::.|
Zfish   675 -----MHCLNNSGSSAT 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_001188938.1	LRR_RI	<21..200	CDD:238064	90/179 (50%)
		leucine-rich repeat	21..41	CDD:275380	8/20 (40%)
		LRR_8	40..98	CDD:290566	27/57 (47%)
		leucine-rich repeat	42..64	CDD:275380	12/21 (57%)
		leucine-rich repeat	65..87	CDD:275380	8/21 (38%)
		LRR_8	86..140	CDD:290566	19/53 (36%)
		leucine-rich repeat	88..110	CDD:275380	9/21 (43%)
		leucine-rich repeat	111..133	CDD:275380	7/21 (33%)
		leucine-rich repeat	134..156	CDD:275380	14/21 (67%)
		LRR_8	156..213	CDD:290566	35/56 (63%)
		leucine-rich repeat	157..179	CDD:275380	15/21 (71%)
		leucine-rich repeat	180..202	CDD:275380	13/21 (62%)
		leucine-rich repeat	203..225	CDD:275380	10/21 (48%)
		leucine-rich repeat	226..248	CDD:275380	4/21 (19%)
		leucine-rich repeat	272..294	CDD:275380	10/27 (37%)
		LRR_8	279..328	CDD:290566	25/54 (46%)
		leucine-rich repeat	295..317	CDD:275380	12/21 (57%)
		leucine-rich repeat	318..340	CDD:275380	10/21 (48%)
		LRR_8	340..396	CDD:290566	21/55 (38%)
		leucine-rich repeat	364..386	CDD:275380	7/21 (33%)
		PDZ_signaling	770..846	CDD:238492
lrrc7	XP_005166019.1	LRR_RI	<37..269	CDD:238064	107/231 (46%)
		leucine-rich repeat	39..60	CDD:275380	8/20 (40%)
		LRR_8	59..117	CDD:290566	27/57 (47%)
		leucine-rich repeat	61..83	CDD:275380	12/21 (57%)
		leucine-rich repeat	84..106	CDD:275380	8/21 (38%)
		leucine-rich repeat	107..152	CDD:275380	17/44 (39%)
		leucine-rich repeat	153..175	CDD:275380	14/21 (67%)
		LRR_8	174..232	CDD:290566	35/57 (61%)
		leucine-rich repeat	176..198	CDD:275380	15/21 (71%)
		leucine-rich repeat	199..221	CDD:275380	13/21 (62%)
		LRR_8	221..278	CDD:290566	19/56 (34%)
		leucine-rich repeat	222..244	CDD:275380	10/21 (48%)
		leucine-rich repeat	245..267	CDD:275380	4/21 (19%)
		LRR_4	266..306	CDD:289563	16/39 (41%)
		leucine-rich repeat	291..319	CDD:275380	10/27 (37%)
		leucine-rich repeat	343..365	CDD:275380	10/21 (48%)
		LRR_8	364..421	CDD:290566	21/56 (38%)
		LRR_4	365..403	CDD:289563	13/37 (35%)
		leucine-rich repeat	366..388	CDD:275380	8/21 (38%)
		LRR_4	387..429	CDD:289563	18/41 (44%)
		leucine-rich repeat	389..411	CDD:275380	7/21 (33%)
		PDZ_signaling	1468..1551	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10481
eggNOG	1	0.900	-	-		E33208_3BA7S
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105355
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.680