DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lap1 and lrrc1

DIOPT Version :9

Sequence 1:	NP_001188938.1	Gene:	Lap1 / 36670	FlyBaseID:	FBgn0033984	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_001013463.1	Gene:	lrrc1 / 541316	ZFINID:	ZDB-GENE-050320-1	Length:	526	Species:	Danio rerio

Alignment Length:	562	Identity:	192/562 - (34%)
Similarity:	292/562 - (51%)	Gaps:	48/562 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CFPCFKFKREEVIDKLDYSNTPLTDFP-EVWQHERTLEELYLSTTRLQALPPQLFYCQGLRVLHV 70
            |.|.::..|.  |:.:|..:..|...| |::::..:||||.|...:|:.||...|....||.|.:
Zfish     4 CIPLWRCNRH--IEAIDRRHCSLLFVPDEIYRYRGSLEELLLDANQLRDLPKPFFNLTKLRKLGL 66

  Fly    71 NSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITSLISLQ 135
            :.|.::.:|..|.:..||..||::||.|:.:||.|..||.|...|.|.|.|.|||::...|.:|.
Zfish    67 SDNEIQRLPGDIANFNQLVELDISRNDIMELPESISYCKTLQVADFSGNPLTRLPESFPELRNLA 131

  Fly   136 ELLLNETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPEVVGEL 200
            .|.:|:..|:.||.|.|.|.||..||||.|.|..||:|:.:|..|:.||:|.||...|||.:|.|
Zfish   132 CLSINDISLQALPDNIGNLCNLVSLELRENLLTYLPESLSQLQKLEELDVGSNELYNLPETIGCL 196

  Fly   201 KSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAFPFS 265
            .||::||:|.||:..:.|.:|.:|.|...:.:.|.|:.||.|:.|..::..|.:..|.::..|..
Zfish   197 VSLKDLWLDGNQLSDIPAEVGSMRSLTCLDVSENKLERLPEEMGNLLSLTDLLVSQNLIDLLPEG 261

  Fly   266 VGMLKSLVTFKCESNGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLFADDNQLRQ 330
            :|.||.|...|.:.|.|.:||:||.:.|.|.||||:.|:|:.||.:||.|:.|.....|.|:|..
Zfish   262 IGKLKRLSILKADQNRLVQLPESIGHCESLTELVLTENQLVNLPRSIGKLKKLSNFNCDRNRLAS 326

  Fly   331 LPDELCSCQQLSVLSVANNQLSALPQNIGNLSKMKVLNVVNNYINALPVSMLNLVNLTSMWLSDN 395
            ||.|:..|..|:||.|..|:|..:|..:...|::.||::..|.:..||:::.:| .|.::|||:|
Zfish   327 LPKEIGGCCSLNVLCVRENRLMRIPPELSQASELHVLDLSGNRLLYLPLTLTSL-RLKALWLSEN 390

  Fly   396 QSQPLVPLQY-LD-ASTKTQLTCFMLPQVTFKMNSIQAQQQAQEQYEFVYANQQQPHASPSRRIC 458
            |||||:..|. :| .|.:..|||.:|||...:..:..:...|:                     |
Zfish   391 QSQPLLTFQTDVDPESGEKVLTCVLLPQQPCESENTGSDNLAR---------------------C 434

  Fly   459 FA----EEATILSNAKAQPAPNYPSFVAAPPTPTPDQMAGSVRLMRSPTPYPKELRQMSKYVRQA 519
            .|    .|::||.:.....|.|..|.:.. .....|:......|:|..||:|.||:.|.|.   |
Zfish   435 GALESLVESSILDDTWDDKAANRMSTIRF-MEDDDDEDDEERTLLRRATPHPGELKNMKKV---A 495

  Fly   520 QAATSSANASEVREARVVTNGQIHCDSN-NANQDVVDQATTS 560
            ::.....||::            ..||| |...:.||:.|||
Zfish   496 ESIRKDMNAAK------------GLDSNKNEVNNAVDRVTTS 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_001188938.1	LRR_RI	<21..200	CDD:238064	71/179 (40%)
		leucine-rich repeat	21..41	CDD:275380	4/20 (20%)
		LRR_8	40..98	CDD:290566	21/57 (37%)
		leucine-rich repeat	42..64	CDD:275380	9/21 (43%)
		leucine-rich repeat	65..87	CDD:275380	6/21 (29%)
		LRR_8	86..140	CDD:290566	23/53 (43%)
		leucine-rich repeat	88..110	CDD:275380	10/21 (48%)
		leucine-rich repeat	111..133	CDD:275380	9/21 (43%)
		leucine-rich repeat	134..156	CDD:275380	9/21 (43%)
		LRR_8	156..213	CDD:290566	29/56 (52%)
		leucine-rich repeat	157..179	CDD:275380	11/21 (52%)
		leucine-rich repeat	180..202	CDD:275380	11/21 (52%)
		leucine-rich repeat	203..225	CDD:275380	8/21 (38%)
		leucine-rich repeat	226..248	CDD:275380	7/21 (33%)
		leucine-rich repeat	272..294	CDD:275380	8/21 (38%)
		LRR_8	279..328	CDD:290566	22/48 (46%)
		leucine-rich repeat	295..317	CDD:275380	12/21 (57%)
		leucine-rich repeat	318..340	CDD:275380	8/21 (38%)
		LRR_8	340..396	CDD:290566	18/55 (33%)
		leucine-rich repeat	364..386	CDD:275380	6/21 (29%)
		PDZ_signaling	770..846	CDD:238492
lrrc1	NP_001013463.1	LRR_RI	23..243	CDD:238064	88/219 (40%)
		LRR_8	37..94	CDD:290566	21/56 (38%)
		leucine-rich repeat	38..60	CDD:275380	9/21 (43%)
		leucine-rich repeat	61..83	CDD:275380	6/21 (29%)
		leucine-rich repeat	84..106	CDD:275380	10/21 (48%)
		leucine-rich repeat	107..129	CDD:275380	9/21 (43%)
		leucine-rich repeat	130..152	CDD:275380	9/21 (43%)
		LRR_8	152..209	CDD:290566	29/56 (52%)
		leucine-rich repeat	153..175	CDD:275380	11/21 (52%)
		leucine-rich repeat	176..198	CDD:275380	11/21 (52%)
		leucine-rich repeat	199..221	CDD:275380	8/21 (38%)
		leucine-rich repeat	222..244	CDD:275380	7/21 (33%)
		leucine-rich repeat	268..290	CDD:275380	8/21 (38%)
		leucine-rich repeat	291..313	CDD:275380	12/21 (57%)
		leucine-rich repeat	337..359	CDD:275380	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I4572
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920