DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lap1 and f-cup

DIOPT Version :9

Sequence 1:	NP_001188938.1	Gene:	Lap1 / 36670	FlyBaseID:	FBgn0033984	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_001262544.1	Gene:	f-cup / 41677	FlyBaseID:	FBgn0028487	Length:	802	Species:	Drosophila melanogaster

Alignment Length:	873	Identity:	194/873 - (22%)
Similarity:	308/873 - (35%)	Gaps:	261/873 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EVWQHERTLEELYLSTTRLQALPPQLFYCQGLRVLHVNSNNLESIPQAIGSLRQL--QHLDLNRN 96
            |:|:..|....|.||...|..:|.:|:          :.|..::..:|: :|.||  :..|...|
  Fly   101 ELWKLARKSGTLNLSNKALARVPKRLY----------DINEADADSKAV-NLEQLTIKEEDAWWN 154

  Fly    97 LIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITSLISLQELLLNETYLEFLPANFGRLVNLRILE 161
               .||        |.:||||.|:|..:...|.:|.||..|.|::..|..||...|:|..|..|.
  Fly   155 ---QVP--------LNNLDLSSNTLTHISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLN 208

  Fly   162 LRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPEVVGELKSLRELWIDFNQIRRVSANIGKLRDL 226
            :..|.|..||::|..|..|:.|:|..|||.||...:.:|..|..|....|.|:.:...||.|..|
  Fly   209 VSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRL 273

  Fly   227 QHFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAFPFSVGMLKSLVTFKCESNGLTELPDSISY 291
            .......|.:..||.:|.|.|:::.:.:..|.|.:.|..:|:|:.|.....:.|.:.|||: ...
  Fly   274 TALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPE-FEG 337

  Fly   292 LEQLEELVLSHNKLIRLPSTI-GMLRSLRFLFADDNQLRQLPDELCSCQQLSVLSVANNQLSALP 355
            .|.|.||..|:|.:..:|..: ..|..|:.|...||::.:||||||..:.|:.|.|:||.:|.||
  Fly   338 NEALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLP 402

  Fly   356 QNIGNLSKMKVLNVVNNYINALPVSMLNLVNLTSMWLSDNQSQPLVPLQ-----YLDASTKTQLT 415
            ..:.:|:.:..|.|..|.|..:...:|...  |:..|.....:.:...:     ..||||...::
  Fly   403 VTLSSLAHLISLQVEGNPIKTIRRDILQCG--TTRILKTLHDRAVAKAKEEGGGVDDASTSAGIS 465

  Fly   416 CFML----------PQVTFKMNSIQAQQQAQEQYEFVYANQQQPHASPSRRICFAEEATILSNAK 470
            ...|          |. .|..:....|||...|....|..|||   ...::.|..|
  Fly   466 VTRLRGGQMDDGDIPG-NFPDSFHHQQQQNGFQCPCSYPCQQQ---QMQQQFCVYE--------- 517

  Fly   471 AQPAPNYPSFVAAPPTPTPDQMAGSVRLMRSPTPYPKELRQMSKYVRQAQAATSSANASEVREAR 535
                                                 .||...:|.||
  Fly   518 -------------------------------------PLRNCQEYDRQ----------------- 528

  Fly   536 VVTNGQIHCDSNNANQDVVDQATTSAIYGIAPETTHIYGVYQQPQQMAHPVPTQEYYGLPLVNYE 600
              |.|:|:...|...|.  ...:..:::           |.||.|:|.:|.|          .|.
  Fly   529 --TQGRIYEPENYQQQH--QNGSLRSLF-----------VQQQQQRMEYPYP----------GYF 568

  Fly   601 AHYQQLYVEANTPLPTTHLNGDQDYELQPLQQQPMQQQALPTPRLEPPPYHIARVYTKKTPEDLN 665
            .:.||                         |||....:..|:.|....|..:
  Fly   569 MYQQQ-------------------------QQQQFSYEQDPSSRSAVHPRWV------------- 595

  Fly   666 LYESMRQRKQQQQLQEQT-----IYQDALN--------SNSNFKTTAIGAQDVEESVDQLDYQNN 717
             |:....|.....|:|.|     ::|.|.:        :.:...|...|.|.:::.|.:|...||
  Fly   596 -YKLRHTRTLAVNLEELTSVPDQVFQIARDEGVHVVDFARNQLSTLPNGLQHMKDLVTELVLSNN 659

  Fly   718 I-------------------SNNLEPNPEEEDQELDDTMSQHS-LNSTATNNTSKASHKKSTWIF 762
            :                   ||||          |:|..::.. ||:....|.:.
  Fly   660 VIGYVPQFISQFTRISFLNLSNNL----------LNDLPTEFGVLNTLRELNIAN---------- 704

  Fly   763 GVHKNPTVK---------QVTLKWENSIGFDIAELLNQVGIFVSSITPNTNAARLLNLNDKLLEI 818
              ::.|.:.         ::.:..||.|     ::||..|:        .|..||..|
  Fly   705 --NRFPCIPNCVYELQGLEILIASENHI-----KMLNVSGL--------QNMRRLSTL------- 747

  Fly   819 DGYDLTNANLSDAKRVLLNCGTVMNIML 846
               ||.|.::.....:|.|...:.::.|
  Fly   748 ---DLRNNDIETVPPILGNLTNITHLEL 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_001188938.1	LRR_RI	<21..200	CDD:238064	52/167 (31%)
		leucine-rich repeat	21..41	CDD:275380	2/6 (33%)
		LRR_8	40..98	CDD:290566	14/59 (24%)
		leucine-rich repeat	42..64	CDD:275380	6/21 (29%)
		leucine-rich repeat	65..87	CDD:275380	3/21 (14%)
		LRR_8	86..140	CDD:290566	18/55 (33%)
		leucine-rich repeat	88..110	CDD:275380	5/23 (22%)
		leucine-rich repeat	111..133	CDD:275380	9/21 (43%)
		leucine-rich repeat	134..156	CDD:275380	8/21 (38%)
		LRR_8	156..213	CDD:290566	20/56 (36%)
		leucine-rich repeat	157..179	CDD:275380	8/21 (38%)
		leucine-rich repeat	180..202	CDD:275380	9/21 (43%)
		leucine-rich repeat	203..225	CDD:275380	7/21 (33%)
		leucine-rich repeat	226..248	CDD:275380	6/21 (29%)
		leucine-rich repeat	272..294	CDD:275380	5/21 (24%)
		LRR_8	279..328	CDD:290566	16/49 (33%)
		leucine-rich repeat	295..317	CDD:275380	7/22 (32%)
		leucine-rich repeat	318..340	CDD:275380	10/21 (48%)
		LRR_8	340..396	CDD:290566	16/55 (29%)
		leucine-rich repeat	364..386	CDD:275380	5/21 (24%)
		PDZ_signaling	770..846	CDD:238492	15/84 (18%)
f-cup	NP_001262544.1	leucine-rich repeat	111..140	CDD:275380	8/39 (21%)
		LRR_RI	155..>377	CDD:238064	73/230 (32%)
		leucine-rich repeat	158..180	CDD:275380	9/21 (43%)
		LRR_8	180..235	CDD:290566	20/54 (37%)
		leucine-rich repeat	181..203	CDD:275380	8/21 (38%)
		leucine-rich repeat	204..226	CDD:275380	8/21 (38%)
		LRR_8	225..283	CDD:290566	18/57 (32%)
		leucine-rich repeat	227..249	CDD:275380	9/21 (43%)
		leucine-rich repeat	250..272	CDD:275380	7/21 (33%)
		LRR_8	272..329	CDD:290566	14/56 (25%)
		leucine-rich repeat	273..295	CDD:275380	6/21 (29%)
		leucine-rich repeat	296..318	CDD:275380	5/21 (24%)
		LRR_8	317..375	CDD:290566	17/58 (29%)
		leucine-rich repeat	319..340	CDD:275380	5/21 (24%)
		leucine-rich repeat	341..364	CDD:275380	7/22 (32%)
		leucine-rich repeat	389..410	CDD:275380	8/20 (40%)
		leucine-rich repeat	411..430	CDD:275380	4/18 (22%)
		leucine-rich repeat	627..650	CDD:275380	3/22 (14%)
		leucine-rich repeat	651..669	CDD:275380	4/17 (24%)
		leucine-rich repeat	697..719	CDD:275380	2/33 (6%)
		LRR_8	719..777	CDD:290566	16/77 (21%)
		leucine-rich repeat	720..743	CDD:275380	7/35 (20%)
		leucine-rich repeat	744..766	CDD:275380	7/31 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47116
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910