DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lap1 and lrrc1

DIOPT Version :9

Sequence 1:	NP_001188938.1	Gene:	Lap1 / 36670	FlyBaseID:	FBgn0033984	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_989386.1	Gene:	lrrc1 / 395020	XenbaseID:	XB-GENE-943417	Length:	524	Species:	Xenopus tropicalis

Alignment Length:	564	Identity:	196/564 - (34%)
Similarity:	289/564 - (51%)	Gaps:	54/564 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CFPCFKFKREEVIDKLDYSNTPLTDFP-EVWQHERTLEELYLSTTRLQALPPQLFYCQGLRVLHV 70
            |.|.::..|.  ::.:|..:..|...| |::::.|:||||.|...:|:.||.|.|....||.|.:
Frog     4 CIPLWRCNRH--VESVDKRHCSLLAVPEEIYRYSRSLEELLLDANQLRELPKQFFQLVKLRKLGL 66

  Fly    71 NSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITSLISLQ 135
            :.|.::.:|..|.:..||..||::||.|..:||.|..||.|...|.|.|.|.||||:...|.||.
Frog    67 SDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPDSFPDLASLT 131

  Fly   136 ELLLNETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPEVVGEL 200
            .|.:|:..|:.||.|.|.|.||..||||.|.|..||:|:.:|..|:.||||.||...|||.:|.|
Frog   132 CLSINDISLQVLPENIGNLSNLVSLELRENLLTFLPESLAQLHRLEELDIGNNELYNLPETIGSL 196

  Fly   201 KSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAFPFS 265
            ..|::||:|.||:..:...||.|::|...:.:.|.|:.||.|:|..:::..|.:..||:|..|..
Frog   197 YKLKDLWLDGNQLADLPPEIGHLKNLLCLDLSENKLERLPEEISGLKSLTDLLVSHNSIEVLPDG 261

  Fly   266 VGMLKSLVTFKCESNGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLFADDNQLRQ 330
            :|.||:|...|.:.|.|.:|.|.|...|.|.||:|:.|:|:.||.:||.|:.|..|..|.|:|..
Frog   262 IGKLKNLSILKVDQNRLMQLTDCIGECESLTELILTENQLLVLPRSIGKLKKLCNLNIDRNKLMS 326

  Fly   331 LPDELCSCQQLSVLSVANNQLSALPQNIGNLSKMKVLNVVNNYINALPVSMLNLVNLTSMWLSDN 395
            ||.|:..|..|:|..|..|:||.:|..|...:::.||:|..|.:..||:|:.:| .|.::|||||
Frog   327 LPKEIGGCCGLNVFCVRENRLSRIPSEIAKATELHVLDVAGNRLTHLPLSLTSL-KLKALWLSDN 390

  Fly   396 QSQPLVPLQ--YLDASTKTQLTCFMLPQVTFKMNSIQAQQQAQEQYEFVYANQQQPHASPSRRIC 458
            ||:||:..|  ....|.:..|||.:.||:                       ..:|....:...|
Frog   391 QSKPLLTFQTDIEPESGEKILTCVLFPQM-----------------------PSEPSGQDNLPRC 432

  Fly   459 FAEEATILS------NAKAQPAPNYPSFVAAPPTPTPDQMAGSVRLMRSPTPYPKELRQMSKYVR 517
            .|.|:.:..      |.||....:...|:........|:   |..|:|..||:|.||:.|.|.|.
Frog   433 GAFESLVNDMSDETWNEKAMNRISAIRFLDDTKEEDDDE---SATLLRRATPHPGELKNMKKTVE 494

  Fly   518 QAQAATSSANASEVREARVVTNGQIHCDSN-NANQDVVDQATTS 560
            ..:   |:.||::            ..||| |...:..|:.|||
Frog   495 NIR---SNLNAAK------------GLDSNKNEVNNATDRVTTS 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_001188938.1	LRR_RI	<21..200	CDD:238064	76/179 (42%)
		leucine-rich repeat	21..41	CDD:275380	4/20 (20%)
		LRR_8	40..98	CDD:290566	23/57 (40%)
		leucine-rich repeat	42..64	CDD:275380	10/21 (48%)
		leucine-rich repeat	65..87	CDD:275380	6/21 (29%)
		LRR_8	86..140	CDD:290566	25/53 (47%)
		leucine-rich repeat	88..110	CDD:275380	10/21 (48%)
		leucine-rich repeat	111..133	CDD:275380	10/21 (48%)
		leucine-rich repeat	134..156	CDD:275380	9/21 (43%)
		LRR_8	156..213	CDD:290566	29/56 (52%)
		leucine-rich repeat	157..179	CDD:275380	11/21 (52%)
		leucine-rich repeat	180..202	CDD:275380	12/21 (57%)
		leucine-rich repeat	203..225	CDD:275380	9/21 (43%)
		leucine-rich repeat	226..248	CDD:275380	7/21 (33%)
		leucine-rich repeat	272..294	CDD:275380	7/21 (33%)
		LRR_8	279..328	CDD:290566	21/48 (44%)
		leucine-rich repeat	295..317	CDD:275380	11/21 (52%)
		leucine-rich repeat	318..340	CDD:275380	9/21 (43%)
		LRR_8	340..396	CDD:290566	21/55 (38%)
		leucine-rich repeat	364..386	CDD:275380	8/21 (38%)
		PDZ_signaling	770..846	CDD:238492
lrrc1	NP_989386.1	leucine-rich repeat	14..37	CDD:275380	4/22 (18%)
		PRK15370	<27..>255	CDD:185268	93/227 (41%)
		leucine-rich repeat	38..60	CDD:275380	10/21 (48%)
		leucine-rich repeat	61..83	CDD:275380	6/21 (29%)
		leucine-rich repeat	84..106	CDD:275380	10/21 (48%)
		leucine-rich repeat	107..129	CDD:275380	10/21 (48%)
		leucine-rich repeat	130..152	CDD:275380	9/21 (43%)
		leucine-rich repeat	153..175	CDD:275380	11/21 (52%)
		LRR	156..>399	CDD:227223	100/243 (41%)
		leucine-rich repeat	176..198	CDD:275380	12/21 (57%)
		leucine-rich repeat	199..221	CDD:275380	9/21 (43%)
		leucine-rich repeat	222..244	CDD:275380	7/21 (33%)
		leucine-rich repeat	245..267	CDD:275380	7/21 (33%)
		leucine-rich repeat	291..313	CDD:275380	11/21 (52%)
		leucine-rich repeat	314..359	CDD:275380	17/44 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010