DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lap1 and scrib

DIOPT Version :9

Sequence 1:	NP_001188938.1	Gene:	Lap1 / 36670	FlyBaseID:	FBgn0033984	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	XP_021333089.1	Gene:	scrib / 368473	ZFINID:	ZDB-GENE-030616-572	Length:	2047	Species:	Danio rerio

Alignment Length:	931	Identity:	274/931 - (29%)
Similarity:	399/931 - (42%)	Gaps:	202/931 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KCFPCFKFKRE-EVIDKLDYSNTPLTDFPEVWQHERTLEELYLSTTRLQALPPQLFYCQGLRVLH 69
            ||.|.::..|. |.:||...|.|.:.|  |::::.|:||||.|...:|:.||...|....||.|.
Zfish     3 KCIPLWRCNRHVESVDKRHCSLTAVPD--EIYRYNRSLEELLLDANQLRELPKPFFRLHNLRKLG 65

  Fly    70 VNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITSLISL 134
            ::.|.::.:|..:.:..||..||::||.|..:||.||.|:.|...|.|.|.|.||||..|.|..|
Zfish    66 LSDNEIQKLPPDVANFTQLVELDISRNDISEIPENIKFCQSLEIADFSGNPLTRLPDGFTQLRGL 130

  Fly   135 QELLLNETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPEVVGE 199
            ..|.||:..|:.||.:.|.|.||..||||.|.|.:||.|:..|:.|::||:|.|....||:.:|.
Zfish   131 AHLSLNDVSLQSLPNDIGNLSNLVTLELRENLLKSLPSSLSFLVKLEQLDLGSNVLEVLPDTLGA 195

  Fly   200 LKSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAFPF 264
            |.:|||||:|.||:..:...:|.||.|...:.:.|.|..||:|:|....:..|.:..|.||..|.
Zfish   196 LPNLRELWLDRNQLSSLPPELGNLRQLVCLDVSENRLSELPTEISGLIALTDLLLSENLLEILPD 260

  Fly   265 SVGMLKSLVTFKCESNGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLFADDNQLR 329
            |:|.||.|...|...|.|..|.|||...|.|.||:|:.|.|..||.::|.|:.|..|..|.|:|.
Zfish   261 SIGSLKKLSILKVNQNRLVHLTDSIGECENLTELMLTENLLQSLPRSLGKLKKLTNLNVDRNRLS 325

  Fly   330 QLPDELCSCQQLSVLSVANNQLSALPQNIGNLSKMKVLNVVNNYINALPVSMLNLVNLTSMWLSD 394
            .:|.||..|..|:|||:.:|:|..||..:.|.:::.||:|..|.:..||.::.|| ||.:|||::
Zfish   326 SVPAELGGCVSLNVLSLRDNRLGKLPPELANATELHVLDVAGNRLQNLPFALANL-NLKAMWLAE 389

  Fly   395 NQSQPLVPLQYLD--ASTKTQLTCFMLPQVTFKMNSIQAQQQAQEQYEFVYANQQQPHASPSRRI 457
            |||||::..|..|  .:.:..|||::||                          |||.:|
Zfish   390 NQSQPMLKFQTEDDEQTGEKVLTCYLLP--------------------------QQPSSS----- 423

  Fly   458 CFAEEATILSNAKAQPAPNYPSFVAAPPTPT-------------------PDQMAGSVR--LMRS 501
                    |.|...:      |...|.||.|                   .|:.|...|  |.|.
Zfish   424 --------LENLLER------SVDEAWPTDTNLNRVSVIQFRDDSKHEEEDDETAADKRQGLQRR 474

  Fly   502 PTPYPKELRQMSKYVRQAQAATSSANASEVREARVVTNGQIHCDSNNANQDVVDQATTSAIYGIA 566
            .||:|.||:.|...:...:....:|...|..|:......::...||.::......:||||
Zfish   475 ATPHPSELKVMKNVIEARRNEAYTARPDEDLESPDAEEKRLSGLSNQSHDSQASSSTTSA----- 534

  Fly   567 PETTHIYGVYQQPQQMAHPVPTQEYYGLPLVNYEAHYQQLY-------VEANTPLPTTHL----- 619
              |:|                 ::..|:.....|.:..|:.       :|.....||.|.
Zfish   535 --TSH-----------------EDKQGINSTGVELNDGQVQEEEDLDEMEVEYTEPTVHFAEEPI 580

  Fly   620 ----NGDQDY-----------ELQPLQQQPMQQQAL---PTPRLE--------PPPYHIARVY-- 656
                :.|.||           |:......|.::|.|   .||..:        |.|..:|.:.
Zfish   581 IRGGDEDDDYDNDDDDAERSDEVSQTPSFPAEKQRLIRKDTPHYKKHFKITKLPKPETVAALLQG 645

  Fly   657 --------TKKTPEDLNLYESMRQRKQQQQLQEQTIYQDALNSNSNFKTTAIGAQDVEESVDQLD 713
                    |..||      |:.|..:..::.:|....:|.|::....:..|...:|:..|
Zfish   646 FSHDGLSPTAHTP------ENERDGEDDEEEEEDEDEEDDLHTPFQHRLDAAELEDIRMS----- 699

  Fly   714 YQNNIS------------NNLEPNPEE-EDQELDDTMSQHSLNSTATNNTSKASHKKSTWIFGVH 765
             |.|.|            |||...|.. |::||  |:|  .|..|.....|.|..|.||...|
Zfish   700 -QMNSSLQPVKGVSFDQVNNLLIEPARIEEEEL--TLS--ILRQTGGLGISIAGGKGSTPYKG-- 757

  Fly   766 KNPTVKQVTLKWENSIGFDIAELLNQVGIFVSSITPNTNAARL-LNLNDKLLEIDGYDLTNANLS 829
                                    :..|||:|.::....|||. :.:.|||||::|.||..|...
Zfish   758 ------------------------DDEGIFISRVSEEGPAARAGVKVGDKLLEVNGVDLHGAEHH 798

  Fly   830 DAKRVLLNCG--TVMNIMLSR 848
            .|...|.|.|  .||.::..|
Zfish   799 TAVEALRNSGAAVVMTVLRER 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_001188938.1	LRR_RI	<21..200	CDD:238064	72/178 (40%)
		leucine-rich repeat	21..41	CDD:275380	5/19 (26%)
		LRR_8	40..98	CDD:290566	21/57 (37%)
		leucine-rich repeat	42..64	CDD:275380	9/21 (43%)
		leucine-rich repeat	65..87	CDD:275380	5/21 (24%)
		LRR_8	86..140	CDD:290566	25/53 (47%)
		leucine-rich repeat	88..110	CDD:275380	11/21 (52%)
		leucine-rich repeat	111..133	CDD:275380	11/21 (52%)
		leucine-rich repeat	134..156	CDD:275380	9/21 (43%)
		LRR_8	156..213	CDD:290566	28/56 (50%)
		leucine-rich repeat	157..179	CDD:275380	11/21 (52%)
		leucine-rich repeat	180..202	CDD:275380	9/21 (43%)
		leucine-rich repeat	203..225	CDD:275380	10/21 (48%)
		leucine-rich repeat	226..248	CDD:275380	7/21 (33%)
		leucine-rich repeat	272..294	CDD:275380	8/21 (38%)
		LRR_8	279..328	CDD:290566	21/48 (44%)
		leucine-rich repeat	295..317	CDD:275380	10/21 (48%)
		leucine-rich repeat	318..340	CDD:275380	9/21 (43%)
		LRR_8	340..396	CDD:290566	22/55 (40%)
		leucine-rich repeat	364..386	CDD:275380	8/21 (38%)
		PDZ_signaling	770..846	CDD:238492	22/78 (28%)
scrib	XP_021333089.1	leucine-rich repeat	14..37	CDD:275380	7/24 (29%)
		LRR	<37..306	CDD:227223	110/268 (41%)
		leucine-rich repeat	38..60	CDD:275380	9/21 (43%)
		leucine-rich repeat	61..83	CDD:275380	5/21 (24%)
		leucine-rich repeat	84..106	CDD:275380	11/21 (52%)
		leucine-rich repeat	107..129	CDD:275380	11/21 (52%)
		leucine-rich repeat	130..152	CDD:275380	9/21 (43%)
		leucine-rich repeat	153..175	CDD:275380	11/21 (52%)
		leucine-rich repeat	176..198	CDD:275380	9/21 (43%)
		LRR	<192..458	CDD:227223	102/311 (33%)
		leucine-rich repeat	199..221	CDD:275380	10/21 (48%)
		leucine-rich repeat	222..248	CDD:275380	7/25 (28%)
		leucine-rich repeat	268..290	CDD:275380	8/21 (38%)
		leucine-rich repeat	291..313	CDD:275380	10/21 (48%)
		leucine-rich repeat	314..336	CDD:275380	9/21 (43%)
		leucine-rich repeat	360..380	CDD:275380	6/19 (32%)
		PDZ_signaling	739..816	CDD:238492	29/102 (28%)
		PDZ_signaling	875..952	CDD:238492
		PDZ_signaling	1004..1092	CDD:238492
		PDZ_signaling	1102..1191	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA7S
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820