DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lap1 and Erbin

DIOPT Version :10

Sequence 1:NP_611007.1 Gene:Lap1 / 36670 FlyBaseID:FBgn0033984 Length:849 Species:Drosophila melanogaster
Sequence 2:XP_017446668.2 Gene:Erbin / 365661 RGDID:1562952 Length:1451 Species:Rattus norvegicus


Alignment Length:843 Identity:272/843 - (32%)
Similarity:416/843 - (49%) Gaps:139/843 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 LLSKCFPCFKFK-REEVIDKLDYSNTPLTDFP-EVWQHERTLEELYLSTTRLQALPPQLFYCQGL 65
            |..:..||...: .||.:..||||:..|...| |::..|:|||||||...:::.||.|||.||.|
  Rat     7 LFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSL 71

  Fly    66 RVLHVNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITS 130
            ..|.:..|:|.::|.:|.:|..|:.||:::|.|...||.||:||.||.::.|.|.:.:|||..:.
  Rat    72 HKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTVVEASVNPISKLPDGFSQ 136

  Fly   131 LISLQELLLNETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPE 195
            |::|.:|.||:.:|||||||||||..|:|||||.|.|..|||:|.||..|:|||:|.|||||:||
  Rat   137 LLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201

  Fly   196 VVGELKSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLE 260
            |:.:|..|||.|:|.|::..:...||.||.|.:.:.:.|.::.:...:|...|::...:.||||:
  Rat   202 VLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSKNNIEMVEEGISTCENLQDFLLSSNSLQ 266

  Fly   261 AFPFSVGMLKSLVTFKCESNGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLFADD 325
            ..|.::|.||::.|.|.:.|.|..|||||..|..:|||..|.|::..|||:||.|.::|...||.
  Rat   267 QLPETIGSLKNVTTLKIDENQLMYLPDSIGGLRSIEELDCSFNEIEALPSSIGQLTNIRTFAADH 331

  Fly   326 NQLRQLPDELCSCQQLSVLSVANNQLSALPQNIGNLSKMKVLNVVNNYINALPVSMLNLVNLTSM 390
            |.|:|||.|:.:.:.::||.:.:|:|..||:.:|::.|:||:|:.:|.:..||.|...|..||:|
  Rat   332 NYLQQLPPEIGNWKNVTVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAM 396

  Fly   391 WLSDNQSQPLVPLQ-YLDAST-KTQLTCFMLPQVTFKMNSIQAQQQAQEQYEFVYANQQ-QPHAS 452
            |||||||:||:||| ..|:.| |..||.:|.|           ||...|...|:..|:. .|...
  Rat   397 WLSDNQSKPLIPLQKETDSETQKMVLTNYMFP-----------QQPRTEDVMFISDNESFNPALW 450

  Fly   453 PSRRICFAEEATILSNAKAQPAPNYPSFVAAPPTPTPDQMAGSVRLMRSPTPYPKELRQMSKYV- 516
            ..:|...|:.|......|.:.        .|||.        ...|.|.|||||.||:.|.|.| 
  Rat   451 EEQRKQRAQVAFECDEDKDER--------EAPPR--------EGNLKRYPTPYPDELKNMVKTVQ 499

  Fly   517 ----RQAQAATSSANASEVREARVVTNGQIHCDSNNANQDVVDQATTSAIYGIAP-ETTHIYGVY 576
                |.....|:..:..::::         |.|....|:|          .|:.| |:.......
  Rat   500 TIVHRLKDEETNEESGRDLKQ---------HEDQQVVNKD----------KGVKPSESITTKSKL 545

  Fly   577 QQPQQMAHPVP-TQEYYGLPLVNYEAHYQQLYVEANTPLPTT--------HL-NGDQDYELQPLQ 631
            .:.::..:.|| |.|    |.....|        .|:|:.|.        || |.|..:|     
  Rat   546 DEREKYMNSVPKTSE----PEAETNA--------GNSPVTTNRKSSGNMKHLVNHDDVFE----- 593

  Fly   632 QQPMQQQALPTPRLEPPPYHIARVYTKKTPEDLNLYESMRQRKQQQQLQEQTIYQDALNSNSNFK 696
                                        ..|:|:..|.|:..:.:..|.|.:|.|..:.:.||.|
  Rat   594 ----------------------------ESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNK 630

  Fly   697 TTAIGAQDVEESVDQLDYQNNISNNLEPNPEEEDQELDDTMSQHSLNSTATNNTSKASHKKSTWI 761
            ..  .|:|.:...|::.:.:|.:|:...:|    ..:.|::   |||:.::.:|:..|..|.   
  Rat   631 KD--DAKDTDSLSDEVTHNSNQNNSNCSSP----SRMSDSV---SLNTDSSQDTALCSPAKQ--- 683

  Fly   762 FGVHKNPTVKQVTLKWENSIGFDIAELLNQVGIFVSSITPNTNAARLLNLNDKL-LEIDGYDL 823
            ..:..|..::|....: ||:      |.|.|.:       |.:......:|||. .::..|||
  Rat   684 IPIDSNSKIRQEDENF-NSL------LQNGVNL-------NNSPEEKFKINDKKDFKLPEYDL 732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lap1NP_611007.1 LRR 12..407 CDD:443914 176/397 (44%)
leucine-rich repeat 21..41 CDD:275380 8/20 (40%)
leucine-rich repeat 42..64 CDD:275380 12/21 (57%)
leucine-rich repeat 65..87 CDD:275380 7/21 (33%)
leucine-rich repeat 88..110 CDD:275380 10/21 (48%)
leucine-rich repeat 111..133 CDD:275380 8/21 (38%)
leucine-rich repeat 134..156 CDD:275380 15/21 (71%)
leucine-rich repeat 157..179 CDD:275380 14/21 (67%)
leucine-rich repeat 180..202 CDD:275380 14/21 (67%)
leucine-rich repeat 203..225 CDD:275380 9/21 (43%)
leucine-rich repeat 226..248 CDD:275380 3/21 (14%)
leucine-rich repeat 272..294 CDD:275380 10/21 (48%)
leucine-rich repeat 295..317 CDD:275380 11/21 (52%)
leucine-rich repeat 318..340 CDD:275380 9/21 (43%)
leucine-rich repeat 364..386 CDD:275380 8/21 (38%)
PDZ_canonical 778..846 CDD:467153 12/47 (26%)
ErbinXP_017446668.2 leucine-rich repeat 24..47 CDD:275380 8/22 (36%)
leucine-rich repeat 48..70 CDD:275380 12/21 (57%)
LRR 67..419 CDD:443914 156/351 (44%)
leucine-rich repeat 71..93 CDD:275380 7/21 (33%)
leucine-rich repeat 94..116 CDD:275380 10/21 (48%)
leucine-rich repeat 117..139 CDD:275380 8/21 (38%)
leucine-rich repeat 140..162 CDD:275380 15/21 (71%)
leucine-rich repeat 163..185 CDD:275380 14/21 (67%)
leucine-rich repeat 186..208 CDD:275380 14/21 (67%)
leucine-rich repeat 209..231 CDD:275380 9/21 (43%)
leucine-rich repeat 278..300 CDD:275380 10/21 (48%)
leucine-rich repeat 301..323 CDD:275380 11/21 (52%)
leucine-rich repeat 347..369 CDD:275380 7/21 (33%)
leucine-rich repeat 370..390 CDD:275380 7/19 (37%)
PDZ_densin_erbin-like 1361..1447 CDD:467231
Blue background indicates that the domain is not in the aligned region.

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