DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lap1 and CG3040

DIOPT Version :9

Sequence 1:	NP_001188938.1	Gene:	Lap1 / 36670	FlyBaseID:	FBgn0033984	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_572372.1	Gene:	CG3040 / 31642	FlyBaseID:	FBgn0029925	Length:	238	Species:	Drosophila melanogaster

Alignment Length:	212	Identity:	65/212 - (30%)
Similarity:	98/212 - (46%)	Gaps:	9/212 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 LMTLPKSMVRLINLQRLDIGGNEFTELPEVVGELKSLRELWIDFNQIRRVSANIGKLRDLQHFEA 231
            |.|..|:.:..|:||||.....:....|.|      |:.|.:..|:..||...:|||..|:|...
  Fly    10 LETAQKTGILKISLQRLQEFPLQLRAYPNV------LKTLDLSENRFERVPDELGKLTLLKHLNL 68

  Fly   232 NGNLLDTLPSELSNWRNVEVLSICSNSLEAFPFSVGMLKSLVTFKCESNGLTELPDSISYLEQLE 296
            :||.|..|...:.....:|||.:..|.|...|.::.....|.|....:|.|.|.|..:..|:||:
  Fly    69 SGNRLVELNEVVGELAKLEVLLLMDNMLTRLPKTLANCTHLKTVNLSNNQLKEFPSMLCGLKQLD 133

  Fly   297 ELVLSHNKLIRLPSTIGMLRSLRFLFADDNQLRQLPDELCSCQQLSVLSVANN--QLSALPQNIG 359
            .|.||.||:..:|:.:|.| .:..|..:.||:..|.:|:..|.:|..|.:..|  |.:|....|.
  Fly   134 VLDLSRNKITDVPADVGGL-FVTELNLNQNQISSLAEEVADCPKLKTLRLEENCLQAAAFTPKIL 197

  Fly   360 NLSKMKVLNVVNNYINA 376
            ..||:..|.|..|..|:
  Fly   198 KDSKICNLAVDGNLFNS 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_001188938.1	LRR_RI	<21..200	CDD:238064	10/32 (31%)
		leucine-rich repeat	21..41	CDD:275380
		LRR_8	40..98	CDD:290566
		leucine-rich repeat	42..64	CDD:275380
		leucine-rich repeat	65..87	CDD:275380
		LRR_8	86..140	CDD:290566
		leucine-rich repeat	88..110	CDD:275380
		leucine-rich repeat	111..133	CDD:275380
		leucine-rich repeat	134..156	CDD:275380
		LRR_8	156..213	CDD:290566	13/45 (29%)
		leucine-rich repeat	157..179	CDD:275380	3/11 (27%)
		leucine-rich repeat	180..202	CDD:275380	6/21 (29%)
		leucine-rich repeat	203..225	CDD:275380	8/21 (38%)
		leucine-rich repeat	226..248	CDD:275380	6/21 (29%)
		leucine-rich repeat	272..294	CDD:275380	7/21 (33%)
		LRR_8	279..328	CDD:290566	17/48 (35%)
		leucine-rich repeat	295..317	CDD:275380	9/21 (43%)
		leucine-rich repeat	318..340	CDD:275380	6/21 (29%)
		LRR_8	340..396	CDD:290566	12/39 (31%)
		leucine-rich repeat	364..386	CDD:275380	4/13 (31%)
		PDZ_signaling	770..846	CDD:238492
CG3040	NP_572372.1	LRR_RI	4..192	CDD:238064	57/188 (30%)
		leucine-rich repeat	18..39	CDD:275380	6/20 (30%)
		LRR_8	40..96	CDD:290566	18/55 (33%)
		leucine-rich repeat	40..62	CDD:275380	8/21 (38%)
		leucine-rich repeat	63..85	CDD:275380	6/21 (29%)
		LRR_8	85..142	CDD:290566	19/56 (34%)
		leucine-rich repeat	86..108	CDD:275380	6/21 (29%)
		leucine-rich repeat	109..131	CDD:275380	7/21 (33%)
		LRR_8	130..185	CDD:290566	18/55 (33%)
		leucine-rich repeat	132..151	CDD:275380	7/18 (39%)
		leucine-rich repeat	154..176	CDD:275380	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47186
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010