Protein Alignment Lap1 and cyr1

DIOPT Version :10

• Sequence 1: NP_611007.1
• Gene: Lap1 / 36670
• FlyBaseID: FBgn0033984
• Length: 849
• Species: Drosophila melanogaster
• Sequence 2: NP_596159.1
• Gene: cyr1 / 2540810
• PomBaseID: SPBC19C7.03
• Length: 1692
• Species: Schizosaccharomyces pombe
• Alignment Length: 560
• Identity: 131/560 - (23%)
• Similarity: 215/560 - (38%)
• Gaps: 138/560 - (24%)

  Fly    10 CFKFKREEVIDKLDYSNT-------PLTDFP--EVWQHER-----------------TLEELYLS 48
            |.|.||      ||.||.       |:|...  ||....|                 :|:||.::
pombe   452 CVKLKR------LDISNNLRSPRGKPITALRQLEVLNMSRNDIYELDPLIFSGLSRNSLKELNIA 510

  Fly    49 TTRLQALPPQLFYCQGLRVLHVNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTH 113
            ..:|..||....|...|..|.::.||..:.|..|..|.||:.|:.:.||:..:..:|.|...|.|
pombe   511 NNKLFFLPHSTRYLVNLTYLDLSYNNFVTFPLIITELSQLETLNFSHNLLSQISSKIGSLVKLKH 575

  Fly   114 LDLSCNSL-QRLP----------------DAITSLISLQEL-----------LL--------NET 142
            |.|..|.| .|||                :|||::.||.|.           ||        :.|
pombe   576 LYLQFNDLSNRLPQEIGLLKNLETIDLSYNAITNIASLSECPKLNSINVACNLLSFYEYSNPSAT 640

  Fly   143 YLEFL--------PA-NFGRLVNLRILELRLNNLMTLPKSMVR-LINLQRLDIGGNEFTELPEVV 197
            :::|.        || ::..||...|...:   |:.|..|::. |:|::.:.:..|.||.:.:.:
pombe   641 FIDFSFCPLTTIDPAFSYSNLVYFDISHAK---LIGLKDSVIETLVNVETVKVNYNHFTSISDAI 702

  Fly   198 GELKSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAF 262
            ..:::|:.|.....::..||.|:|||:.|.|.:.:.|.:...|.|:....:::|:::.||.||..
pombe   703 SAMQNLKYLSCTNCEMSYVSPNLGKLKHLVHLDLHANNIKIFPEEVWQVSSLKVVNLSSNILEKI 767

  Fly   263 PFSVGMLKSL--------VTFKCESNGLTELPD------------------------SISYLEQL 295
            ...|...|.|        :......|.::.|..                        ::.|.:.|
pombe   768 KLPVATSKKLTRTISQLKIMRTLSGNPVSSLSSQEFVMPTVEELYLVDNRLGNDCFTALEYFKCL 832

  Fly   296 EELVLSHNKLIRLPSTIGM-LRSLRFLFADDNQLRQLPDELCSCQQLSVLSVANNQLSALPQNIG 359
            :.|.||:|.|..:||.... ...|:.||...|:|..|.....:...|..|....|:||:.|:|..
pombe   833 KVLNLSYNYLTEIPSKFFQNFSDLKHLFVSGNELANLSISSTAQVLLETLYANGNRLSSFPKNEA 897

  Fly   360 NLSKMKVLNVVNNYINALPVSMLNLVNLTSMWLSDNQSQPLVPLQYLDAS----------TKTQL 414
            ....::.|::..|.:..|.|......:||.          |..|:||:.|          ..|..
pombe   898 LSKSLRFLDISTNNLQNLAVEKAEKKSLTK----------LPQLEYLNLSGNTWFRFSEHEDTNF 952

  Fly   415 TCFMLPQVTF----KMNSIQAQQQAQEQYEFVYANQQQPH 450
            |...|..:.|    .:|:..:...:.....|:..|..||:
pombe   953 TKSYLKNLKFLSIMDLNTKFSNAPSDVLNHFIQRNSPQPN 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_611007.1	LRR	12..407	CDD:443914	119/499 (24%)
		leucine-rich repeat	21..41	CDD:275380	9/45 (20%)
		leucine-rich repeat	42..64	CDD:275380	7/21 (33%)
		leucine-rich repeat	65..87	CDD:275380	7/21 (33%)
		leucine-rich repeat	88..110	CDD:275380	6/21 (29%)
		leucine-rich repeat	111..133	CDD:275380	12/38 (32%)
		leucine-rich repeat	134..156	CDD:275380	9/49 (18%)
		leucine-rich repeat	157..179	CDD:275380	5/22 (23%)
		leucine-rich repeat	180..202	CDD:275380	3/21 (14%)
		leucine-rich repeat	203..225	CDD:275380	8/21 (38%)
		leucine-rich repeat	226..248	CDD:275380	5/21 (24%)
		leucine-rich repeat	272..294	CDD:275380	4/53 (8%)
		leucine-rich repeat	295..317	CDD:275380	8/22 (36%)
		leucine-rich repeat	318..340	CDD:275380	6/21 (29%)
		leucine-rich repeat	364..386	CDD:275380	4/21 (19%)
		PDZ_canonical	778..846	CDD:467153
cyr1	NP_596159.1	Ad_cyc_g-alpha	155..200	CDD:129025
		RA_CYR1_like	294..391	CDD:340734
		leucine-rich repeat	409..430	CDD:275380
		LRR	430..>711	CDD:443914	67/267 (25%)
		leucine-rich repeat	431..454	CDD:275380	1/1 (100%)
		leucine-rich repeat	455..477	CDD:275380	8/27 (30%)
		leucine-rich repeat	478..503	CDD:275380	3/24 (13%)
		leucine-rich repeat	504..526	CDD:275380	7/21 (33%)
		leucine-rich repeat	527..549	CDD:275380	7/21 (33%)
		leucine-rich repeat	550..572	CDD:275380	6/21 (29%)
		leucine-rich repeat	573..596	CDD:275380	9/22 (41%)
		LRR	589..990	CDD:443914	86/413 (21%)
		leucine-rich repeat	597..618	CDD:275380	6/20 (30%)
		leucine-rich repeat	661..684	CDD:275380	7/25 (28%)
		leucine-rich repeat	685..707	CDD:275380	3/21 (14%)
		leucine-rich repeat	708..730	CDD:275380	8/21 (38%)
		leucine-rich repeat	754..783	CDD:275380	8/28 (29%)
		leucine-rich repeat	784..807	CDD:275380	2/22 (9%)
		leucine-rich repeat	808..831	CDD:275380	1/22 (5%)
		leucine-rich repeat	832..855	CDD:275380	8/22 (36%)
		leucine-rich repeat	856..877	CDD:275380	6/20 (30%)
		leucine-rich repeat	879..901	CDD:275380	7/21 (33%)
		leucine-rich repeat	902..930	CDD:275380	7/37 (19%)
		PP2C	1032..1268	CDD:395385
		Guanylate_cyc	1323..1519	CDD:425528