DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lap1 and cyr1

DIOPT Version :9

Sequence 1:	NP_001188938.1	Gene:	Lap1 / 36670	FlyBaseID:	FBgn0033984	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_596159.1	Gene:	cyr1 / 2540810	PomBaseID:	SPBC19C7.03	Length:	1692	Species:	Schizosaccharomyces pombe

Alignment Length:	560	Identity:	131/560 - (23%)
Similarity:	215/560 - (38%)	Gaps:	138/560 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CFKFKREEVIDKLDYSNT-------PLTDFP--EVWQHER-----------------TLEELYLS 48
            |.|.||      ||.||.       |:|...  ||....|                 :|:||.::
pombe   452 CVKLKR------LDISNNLRSPRGKPITALRQLEVLNMSRNDIYELDPLIFSGLSRNSLKELNIA 510

  Fly    49 TTRLQALPPQLFYCQGLRVLHVNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTH 113
            ..:|..||....|...|..|.::.||..:.|..|..|.||:.|:.:.||:..:..:|.|...|.|
pombe   511 NNKLFFLPHSTRYLVNLTYLDLSYNNFVTFPLIITELSQLETLNFSHNLLSQISSKIGSLVKLKH 575

  Fly   114 LDLSCNSL-QRLP----------------DAITSLISLQEL-----------LL--------NET 142
            |.|..|.| .|||                :|||::.||.|.           ||        :.|
pombe   576 LYLQFNDLSNRLPQEIGLLKNLETIDLSYNAITNIASLSECPKLNSINVACNLLSFYEYSNPSAT 640

  Fly   143 YLEFL--------PA-NFGRLVNLRILELRLNNLMTLPKSMVR-LINLQRLDIGGNEFTELPEVV 197
            :::|.        || ::..||...|...:   |:.|..|::. |:|::.:.:..|.||.:.:.:
pombe   641 FIDFSFCPLTTIDPAFSYSNLVYFDISHAK---LIGLKDSVIETLVNVETVKVNYNHFTSISDAI 702

  Fly   198 GELKSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAF 262
            ..:::|:.|.....::..||.|:|||:.|.|.:.:.|.:...|.|:....:::|:::.||.||..
pombe   703 SAMQNLKYLSCTNCEMSYVSPNLGKLKHLVHLDLHANNIKIFPEEVWQVSSLKVVNLSSNILEKI 767

  Fly   263 PFSVGMLKSL--------VTFKCESNGLTELPD------------------------SISYLEQL 295
            ...|...|.|        :......|.::.|..                        ::.|.:.|
pombe   768 KLPVATSKKLTRTISQLKIMRTLSGNPVSSLSSQEFVMPTVEELYLVDNRLGNDCFTALEYFKCL 832

  Fly   296 EELVLSHNKLIRLPSTIGM-LRSLRFLFADDNQLRQLPDELCSCQQLSVLSVANNQLSALPQNIG 359
            :.|.||:|.|..:||.... ...|:.||...|:|..|.....:...|..|....|:||:.|:|..
pombe   833 KVLNLSYNYLTEIPSKFFQNFSDLKHLFVSGNELANLSISSTAQVLLETLYANGNRLSSFPKNEA 897

  Fly   360 NLSKMKVLNVVNNYINALPVSMLNLVNLTSMWLSDNQSQPLVPLQYLDAS----------TKTQL 414
            ....::.|::..|.:..|.|......:||.          |..|:||:.|          ..|..
pombe   898 LSKSLRFLDISTNNLQNLAVEKAEKKSLTK----------LPQLEYLNLSGNTWFRFSEHEDTNF 952

  Fly   415 TCFMLPQVTF----KMNSIQAQQQAQEQYEFVYANQQQPH 450
            |...|..:.|    .:|:..:...:.....|:..|..||:
pombe   953 TKSYLKNLKFLSIMDLNTKFSNAPSDVLNHFIQRNSPQPN 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_001188938.1	LRR_RI	<21..200	CDD:238064	62/250 (25%)
		leucine-rich repeat	21..41	CDD:275380	9/45 (20%)
		LRR_8	40..98	CDD:290566	19/74 (26%)
		leucine-rich repeat	42..64	CDD:275380	7/21 (33%)
		leucine-rich repeat	65..87	CDD:275380	7/21 (33%)
		LRR_8	86..140	CDD:290566	24/89 (27%)
		leucine-rich repeat	88..110	CDD:275380	6/21 (29%)
		leucine-rich repeat	111..133	CDD:275380	12/38 (32%)
		leucine-rich repeat	134..156	CDD:275380	9/49 (18%)
		LRR_8	156..213	CDD:290566	11/57 (19%)
		leucine-rich repeat	157..179	CDD:275380	5/22 (23%)
		leucine-rich repeat	180..202	CDD:275380	3/21 (14%)
		leucine-rich repeat	203..225	CDD:275380	8/21 (38%)
		leucine-rich repeat	226..248	CDD:275380	5/21 (24%)
		leucine-rich repeat	272..294	CDD:275380	4/53 (8%)
		LRR_8	279..328	CDD:290566	15/73 (21%)
		leucine-rich repeat	295..317	CDD:275380	8/22 (36%)
		leucine-rich repeat	318..340	CDD:275380	6/21 (29%)
		LRR_8	340..396	CDD:290566	13/55 (24%)
		leucine-rich repeat	364..386	CDD:275380	4/21 (19%)
		PDZ_signaling	770..846	CDD:238492
cyr1	NP_596159.1	Ad_cyc_g-alpha	155..200	CDD:129025
		UBQ	292..387	CDD:294102
		leucine-rich repeat	409..430	CDD:275380
		leucine-rich repeat	431..454	CDD:275380	1/1 (100%)
		LRR_RI	<441..616	CDD:238064	48/169 (28%)
		leucine-rich repeat	455..477	CDD:275380	8/27 (30%)
		LRR_8	476..537	CDD:290566	13/60 (22%)
		leucine-rich repeat	478..503	CDD:275380	3/24 (13%)
		leucine-rich repeat	504..526	CDD:275380	7/21 (33%)
		leucine-rich repeat	527..549	CDD:275380	7/21 (33%)
		LRR_8	548..607	CDD:290566	16/58 (28%)
		leucine-rich repeat	550..572	CDD:275380	6/21 (29%)
		leucine-rich repeat	573..596	CDD:275380	9/22 (41%)
		leucine-rich repeat	597..618	CDD:275380	6/20 (30%)
		leucine-rich repeat	661..684	CDD:275380	7/25 (28%)
		leucine-rich repeat	685..707	CDD:275380	3/21 (14%)
		leucine-rich repeat	708..730	CDD:275380	8/21 (38%)
		LRR_RI	<724..941	CDD:238064	52/226 (23%)
		leucine-rich repeat	754..783	CDD:275380	8/28 (29%)
		leucine-rich repeat	784..807	CDD:275380	2/22 (9%)
		leucine-rich repeat	808..831	CDD:275380	1/22 (5%)
		LRR_8	832..889	CDD:290566	17/56 (30%)
		leucine-rich repeat	832..855	CDD:275380	8/22 (36%)
		leucine-rich repeat	856..877	CDD:275380	6/20 (30%)
		leucine-rich repeat	879..901	CDD:275380	7/21 (33%)
		leucine-rich repeat	902..930	CDD:275380	7/37 (19%)
		PP2C	1032..1268	CDD:278884
		CYCc	1300..1488	CDD:214485
		Nucleotidyl_cyc_III	1323..1519	CDD:299850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47116
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910