Protein Alignment Lap1 and LRRC8B

DIOPT Version :10

• Sequence 1: NP_611007.1
• Gene: Lap1 / 36670
• FlyBaseID: FBgn0033984
• Length: 849
• Species: Drosophila melanogaster
• Sequence 2: NP_056165.1
• Gene: LRRC8B / 23507
• HGNCID: 30692
• Length: 803
• Species: Homo sapiens
• Alignment Length: 360
• Identity: 107/360 - (29%)
• Similarity: 169/360 - (46%)
• Gaps: 22/360 - (6%)

  Fly    11 FKFKREEVIDKLDYSNTPLTDFPEVWQHERTLEELYLSTTRLQALPPQL-FYCQGLRVLHVNSNN 74
            |:....||   |.....|....|........|:||.:..:.|....|.| |..:.|::|.:....
Human   437 FELTEMEV---LSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTE 498

  Fly    75 LESIPQAIGSLRQLQHLDLNRNLIVNVPEEI--------KSCKHLTHLDLSCNSLQRLPDAITSL 131
            :..||:.:..|:.|:.|.|:..::   ||::        :..|:|..|.|. :||.|:|..:|.|
Human   499 MGKIPRWVFHLKNLKELYLSGCVL---PEQLSTMQLEGFQDLKNLRTLYLK-SSLSRIPQVVTDL 559

  Fly   132 I-SLQELLL-NETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELP 194
            : |||:|.| ||.....:..|..::|||:.|||...:|..:|.|:..|.||..||:..|....:.
Human   560 LPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVE 624

  Fly   195 EVVG--ELKSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSN 257
            |::.  .|::|..|.:..|.|..:.|.||.|.:|:....:.|.::.||.:|.....:..|.:..|
Human   625 EIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYN 689

  Fly   258 SLEAFPFSVGMLKSLVTFKCESNGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLF 322
            .|...|..:..|.:|..|...:|.:..|||.:...::|:.|:|..|.|:.|...:|.|.:|..|.
Human   690 HLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLE 754

  Fly   323 ADDNQLRQLPDELCSCQQL--SVLSVANNQLSALP 355
            ...|.|..||.||..||.|  :.|.|..|.|:.||
Human   755 LIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_611007.1	LRR	12..407	CDD:443914	106/359 (30%)
		leucine-rich repeat	21..41	CDD:275380	3/19 (16%)
		leucine-rich repeat	42..64	CDD:275380	7/22 (32%)
		leucine-rich repeat	65..87	CDD:275380	5/21 (24%)
		leucine-rich repeat	88..110	CDD:275380	5/29 (17%)
		leucine-rich repeat	111..133	CDD:275380	9/22 (41%)
		leucine-rich repeat	134..156	CDD:275380	7/22 (32%)
		leucine-rich repeat	157..179	CDD:275380	8/21 (38%)
		leucine-rich repeat	180..202	CDD:275380	6/23 (26%)
		leucine-rich repeat	203..225	CDD:275380	8/21 (38%)
		leucine-rich repeat	226..248	CDD:275380	5/21 (24%)
		leucine-rich repeat	272..294	CDD:275380	6/21 (29%)
		leucine-rich repeat	295..317	CDD:275380	8/21 (38%)
		leucine-rich repeat	318..340	CDD:275380	9/21 (43%)
		leucine-rich repeat	364..386	CDD:275380
		PDZ_canonical	778..846	CDD:467153
LRRC8B	NP_056165.1	Pannexin_like	1..334	CDD:463622
		LRR 1	464..486		7/21 (33%)
		leucine-rich repeat	465..488	CDD:275380	7/22 (32%)
		LRR 2	488..509		4/20 (20%)
		leucine-rich repeat	489..511	CDD:275380	5/21 (24%)
		LRR	511..>789	CDD:443914	87/281 (31%)
		LRR 3	511..532		5/23 (22%)
		leucine-rich repeat	512..539	CDD:275380	5/29 (17%)
		LRR 4	539..559		8/20 (40%)
		leucine-rich repeat	540..562	CDD:275380	9/22 (41%)
		LRR 5	562..582		8/19 (42%)
		leucine-rich repeat	563..609	CDD:275380	17/45 (38%)
		LRR 6	586..607		8/20 (40%)
		LRR 7	609..630		6/20 (30%)
		leucine-rich repeat	610..634	CDD:275380	6/23 (26%)
		LRR 8	634..655		7/20 (35%)
		leucine-rich repeat	635..657	CDD:275380	8/21 (38%)
		LRR 9	657..678		5/20 (25%)
		leucine-rich repeat	658..680	CDD:275380	5/21 (24%)
		LRR 10	680..701		4/20 (20%)
		leucine-rich repeat	681..703	CDD:275380	5/21 (24%)
		LRR 11	703..724		6/20 (30%)
		leucine-rich repeat	704..726	CDD:275380	6/21 (29%)
		LRR 12	726..747		7/20 (35%)
		leucine-rich repeat	727..749	CDD:275380	8/21 (38%)
		LRR 13	749..771		8/21 (38%)
		leucine-rich repeat	750..772	CDD:275380	9/21 (43%)
		leucine-rich repeat	773..796	CDD:275380	7/17 (41%)