DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lap1 and PHLPP2

DIOPT Version :10

Sequence 1:NP_611007.1 Gene:Lap1 / 36670 FlyBaseID:FBgn0033984 Length:849 Species:Drosophila melanogaster
Sequence 2:NP_055835.2 Gene:PHLPP2 / 23035 HGNCID:29149 Length:1323 Species:Homo sapiens


Alignment Length:474 Identity:132/474 - (27%)
Similarity:210/474 - (44%) Gaps:73/474 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 CFKFKREEVIDKLDYSN--TPLTDFPEVWQHERT--LEELY---------LSTTRLQALPPQLFY 61
            |:..  |||.:.|.||.  |.|.......|.||.  |:.||         ||..:|...|..|..
Human   258 CYSL--EEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCE 320

  Fly    62 CQGLRVLHVNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPD 126
            ...|..|:::.|....:|..||:|..||.|.|:.|.:..:|||:.:.:.|:.|.:|.|:..::|:
Human   321 ISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPE 385

  Fly   127 AITSLISLQELLLNETYLEFLPANFG---RLVNLRILELRLNNLMTLPKSMVRLINLQ------R 182
            ....|..|..:::....||.|  |.|   |:.:::.::||:|:|    |:|| :.||:      .
Human   386 VYEKLTMLDRVVMAGNCLEVL--NLGVLNRMNHIKHVDLRMNHL----KTMV-IENLEGNKHITH 443

  Fly   183 LDIGGNEFTELPEVVGELKSLRELWIDFNQIRRVSANIGKLRD-------------------LQH 228
            :|:..|..|:|.  :..|.||.:|....||:|.::.:...||.                   |..
Human   444 VDLRDNRLTDLD--LSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTF 506

  Fly   229 FEANGNLLDTLPSELSNWRNVEVLSICSNSLEAFPFSVGMLKSLVTFKCESNGLTELPDSISYLE 293
            .:.:.|||:.:|......:.:|||.:..|.|...|..:....||.......|.:..||..:.:: 
Human   507 LDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHI- 570

  Fly   294 QLEELVLSHNKLIRLPSTI-GMLRSLRFLFADDNQLRQLPDELCSCQQLSVLS---VANNQLS-- 352
            .||.|.|.||.|.|||.|: ....:||:|.|..|.|..||......:.||:|.   :.||.|:  
Human   571 PLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQ 635

  Fly   353 ALPQNIGNLSKMKVLNVVNNYINALPVSMLN-LVNLTSMWLSDNQSQPLVPLQYLDASTKTQLTC 416
            .:|..:|:| .:::|::.||.:...|.|.|| |..|..:.||.|:.: .:|....:......|..
Human   636 CIPVLVGHL-HLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLK-TIPTTIANCKRLHTLVA 698

  Fly   417 -----------FMLPQVTF 424
                       ..|||:.|
Human   699 HSNNISIFPEILQLPQIQF 717

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lap1NP_611007.1 LRR 12..407 CDD:443914 126/442 (29%)
leucine-rich repeat 21..41 CDD:275380 7/21 (33%)
leucine-rich repeat 42..64 CDD:275380 8/30 (27%)
leucine-rich repeat 65..87 CDD:275380 7/21 (33%)
leucine-rich repeat 88..110 CDD:275380 8/21 (38%)
leucine-rich repeat 111..133 CDD:275380 6/21 (29%)
leucine-rich repeat 134..156 CDD:275380 7/24 (29%)
leucine-rich repeat 157..179 CDD:275380 7/21 (33%)
leucine-rich repeat 180..202 CDD:275380 6/27 (22%)
leucine-rich repeat 203..225 CDD:275380 6/21 (29%)
leucine-rich repeat 226..248 CDD:275380 5/21 (24%)
leucine-rich repeat 272..294 CDD:275380 4/21 (19%)
leucine-rich repeat 295..317 CDD:275380 11/22 (50%)
leucine-rich repeat 318..340 CDD:275380 8/21 (38%)
leucine-rich repeat 364..386 CDD:275380 8/22 (36%)
PDZ_canonical 778..846 CDD:467153
PHLPP2NP_055835.2 RA_PHLPP2 31..142 CDD:340761
PH_PHLPP-like 149..243 CDD:270131
LRR 1 250..271 5/14 (36%)
LRR 251..596 CDD:443914 97/349 (28%)
leucine-rich repeat 253..273 CDD:275380 7/16 (44%)
LRR 2 273..296 6/22 (27%)
leucine-rich repeat 274..300 CDD:275380 8/25 (32%)
LRR 3 300..321 5/20 (25%)
leucine-rich repeat 301..323 CDD:275380 5/21 (24%)
LRR 4 323..344 6/20 (30%)
leucine-rich repeat 324..346 CDD:275380 7/21 (33%)
LRR 5 346..368 8/21 (38%)
leucine-rich repeat 347..369 CDD:275380 8/21 (38%)
LRR 6 369..390 5/20 (25%)
leucine-rich repeat 370..416 CDD:275380 13/47 (28%)
LRR 7 392..412 6/21 (29%)
LRR 8 416..439 9/27 (33%)
leucine-rich repeat 418..440 CDD:275380 9/26 (35%)
LRR 9 440..460 4/21 (19%)
leucine-rich repeat 442..461 CDD:275380 5/20 (25%)
LRR 10 461..480 6/18 (33%)
leucine-rich repeat 462..481 CDD:275380 5/18 (28%)
LRR 470..>772 CDD:443914 67/251 (27%)
LRR 11 481..502 2/20 (10%)
leucine-rich repeat 482..503 CDD:275380 2/20 (10%)
LRR 12 503..524 5/20 (25%)
leucine-rich repeat 504..526 CDD:275380 5/21 (24%)
LRR 13 526..547 6/20 (30%)
leucine-rich repeat 527..549 CDD:275380 6/21 (29%)
LRR 14 549..570 5/20 (25%)
leucine-rich repeat 550..565 CDD:275380 3/14 (21%)
LRR 15 571..592 11/20 (55%)
leucine-rich repeat 572..595 CDD:275380 11/22 (50%)
LRR 16 595..616 8/20 (40%)
leucine-rich repeat 596..645 CDD:275380 17/49 (35%)
LRR 17 621..644 6/22 (27%)
LRR 18 645..666 6/20 (30%)
leucine-rich repeat 646..669 CDD:275380 8/22 (36%)
LRR 19 669..690 5/21 (24%)
leucine-rich repeat 670..692 CDD:275380 5/22 (23%)
LRR 20 692..713 1/20 (5%)
leucine-rich repeat 693..714 CDD:275380 2/20 (10%)
LRR 21 714..735 2/4 (50%)
leucine-rich repeat 715..734 CDD:275380 1/3 (33%)
LRR 22 737..758
leucine-rich repeat 738..764 CDD:275380
PP2Cc 784..1033 CDD:238083
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1060..1157
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1285..1323
Blue background indicates that the domain is not in the aligned region.

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