DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lap1 and Lrrc1

DIOPT Version :9

Sequence 1:	NP_001188938.1	Gene:	Lap1 / 36670	FlyBaseID:	FBgn0033984	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	XP_030100078.1	Gene:	Lrrc1 / 214345	MGIID:	2442313	Length:	580	Species:	Mus musculus

Alignment Length:	468	Identity:	165/468 - (35%)
Similarity:	237/468 - (50%)	Gaps:	64/468 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 IVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITSLISLQELLLNETYLEFLPANFGRLVNLRILEL 162
            |..:||.|..||.|...|.|.|.|.|||::...|.:|..|.:|:..|:.||.|.|.|.||..|||
Mouse   150 IPEIPESIAFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLEL 214

  Fly   163 RLNNLMTLPKSMVRLINLQRLDIGGNEFTELPEVVGELKSLRELWIDFNQIRRVSANIGKLRDLQ 227
            |.|.|..||.|:.:|..|:.||:|.||...|||.:|.|..|::||:|.||:..:...||.|::|.
Mouse   215 RENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLL 279

  Fly   228 HFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAFPFSVGMLKSLVTFKCESNGLTELPDSISYL 292
            ..:.:.|.|:.||.|:|...::..|.|..|.||..|..:|.||.|...|.:.|.||:||::|...
Mouse   280 CLDVSENRLERLPEEISGLTSLTYLVISQNLLETIPEGIGKLKKLSILKLDQNRLTQLPEAIGDC 344

  Fly   293 EQLEELVLSHNKLIRLPSTIGMLRSLRFLFADDNQLRQLPDELCSCQQLSVLSVANNQLSALPQN 357
            |.|.||||:.|:|:.||.:||.|:.|..|.||.|:|..||.|:..|..|::..:.:|:|:.||..
Mouse   345 ENLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTMFCIRDNRLTRLPAE 409

  Fly   358 IGNLSKMKVLNVVNNYINALPVSMLNLVNLTSMWLSDNQSQPLVPLQY-LDASTKTQ-LTCFMLP 420
            :....::.||:|..|.::.||:|:..| .|.::||||||||||:..|. :|.:|..: |||.:||
Mouse   410 VSQAVELHVLDVAGNRLHHLPLSLTTL-KLKALWLSDNQSQPLLTFQTDIDRATGEKILTCVLLP 473

  Fly   421 QVTFKMNSIQAQQQAQEQYEFVYANQQQPHASPSRRIC----------------FAEEATILSNA 469
            |:                              ||..||                .:|||.   |.
Mouse   474 QM------------------------------PSEPICQESLPRCGALESLVTDMSEEAW---ND 505

  Fly   470 KAQPAPNYPSFVAAPPTPTPDQMAGSVR-LMRSPTPYPKELRQMSKYVRQAQAATSSA-----NA 528
            ::....:...|:    ....|:.....| |.|..||:|.||:.|.|.|...:...::|     |.
Mouse   506 RSVHRVSAIRFL----EDEKDEDENETRTLQRRATPHPGELKNMKKTVENLRNDMNAAKGLDSNK 566

  Fly   529 SEVREA--RVVTN 539
            :||..|  ||.|:
Mouse   567 NEVNHAAERVTTS 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_001188938.1	LRR_RI	<21..200	CDD:238064	46/101 (46%)
		leucine-rich repeat	21..41	CDD:275380
		LRR_8	40..98	CDD:290566	165/468 (35%)
		leucine-rich repeat	42..64	CDD:275380
		leucine-rich repeat	65..87	CDD:275380
		LRR_8	86..140	CDD:290566	17/41 (41%)
		leucine-rich repeat	88..110	CDD:275380	5/11 (45%)
		leucine-rich repeat	111..133	CDD:275380	9/21 (43%)
		leucine-rich repeat	134..156	CDD:275380	9/21 (43%)
		LRR_8	156..213	CDD:290566	28/56 (50%)
		leucine-rich repeat	157..179	CDD:275380	11/21 (52%)
		leucine-rich repeat	180..202	CDD:275380	11/21 (52%)
		leucine-rich repeat	203..225	CDD:275380	9/21 (43%)
		leucine-rich repeat	226..248	CDD:275380	7/21 (33%)
		leucine-rich repeat	272..294	CDD:275380	8/21 (38%)
		LRR_8	279..328	CDD:290566	24/48 (50%)
		leucine-rich repeat	295..317	CDD:275380	12/21 (57%)
		leucine-rich repeat	318..340	CDD:275380	10/21 (48%)
		LRR_8	340..396	CDD:290566	18/55 (33%)
		leucine-rich repeat	364..386	CDD:275380	8/21 (38%)
		PDZ_signaling	770..846	CDD:238492
Lrrc1	XP_030100078.1	PRK12323	<4..>158	CDD:237057	3/7 (43%)
		LRR	146..446	CDD:227223	120/296 (41%)
		leucine-rich repeat	163..185	CDD:275380	9/21 (43%)
		leucine-rich repeat	186..208	CDD:275380	9/21 (43%)
		leucine-rich repeat	209..231	CDD:275380	11/21 (52%)
		leucine-rich repeat	232..254	CDD:275380	11/21 (52%)
		leucine-rich repeat	255..277	CDD:275380	9/21 (43%)
		leucine-rich repeat	278..300	CDD:275380	7/21 (33%)
		leucine-rich repeat	301..346	CDD:275380	17/44 (39%)
		leucine-rich repeat	347..369	CDD:275380	12/21 (57%)
		leucine-rich repeat	370..392	CDD:275380	10/21 (48%)
		leucine-rich repeat	416..437	CDD:275380	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA7S
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820