DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lap1 and Lrrc7

DIOPT Version :9

Sequence 1:	NP_001188938.1	Gene:	Lap1 / 36670	FlyBaseID:	FBgn0033984	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_001380603.1	Gene:	Lrrc7 / 117284	RGDID:	708527	Length:	1542	Species:	Rattus norvegicus

Alignment Length:	996	Identity:	295/996 - (29%)
Similarity:	448/996 - (44%)	Gaps:	251/996 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLSKCFPCFKFK-REEVIDKLDYSNTPLTDFP-EVWQHERTLEELYLSTTRLQALPPQLFYCQGL 65
            |:.:..||..|: .||:|..||||:..|...| ||:..|||||||||...:::.||.|||.||.|
  Rat    12 LIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQAL 76

  Fly    66 RVLHVNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITS 130
            |.|.:..|:|.|:|.:|.||..|:.||:::|.:...||.||.||.||.::.|.|.:.:|||..|.
  Rat    77 RKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQ 141

  Fly   131 LISLQELLLNETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPE 195
            |::|.:|.||:.:||||||||||||.|||||||.|:|.||||||.:|..|:|||:|.|||:||||
  Rat   142 LLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFSELPE 206

  Fly   196 VVGELKSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLE 260
            |:.::::|||||:|.|.::.:..:||||:.|.:.:.:.|.::|:..::|....:|.|.:.||.|:
  Rat   207 VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQ 271

  Fly   261 AFPFSVGMLKSLVTFKCESNGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLFADD 325
            ..|.|:|:||.|.|.|.:.|.||.||::|..|..|||...|.|:|..||.|||.|.|||.|..|:
  Rat   272 QLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDE 336

  Fly   326 NQLRQLPDELCSCQQLSVLSVANNQLSALPQNIGNLSKMKVLNVVNNYINALPVSMLNLVNLTSM 390
            |.|.:||.|:.||:.::|:|:.:|:|..||:.||.:.:::|||:.:|.:..||.|...|..|.::
  Rat   337 NFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNLPFSFTKLKELAAL 401

  Fly   391 WLSDNQSQPLVPLQYLDASTKTQ---LTCFMLPQ-----VTFKMNS---------IQAQQQAQEQ 438
            |||||||:.|:||| .:|..:|:   ||.:|.||     ..|:.:|         .|.||:....
  Rat   402 WLSDNQSKALIPLQ-TEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVA 465

  Fly   439 YEFVYANQQQPHASPSRRI-----------------------CFAEEATILSNAKAQPAPN---- 476
            :||....:....|...:.:                       |....|......:..|.|.
  Rat   466 FEFEDKKEDDESAGKVKALSCQAPWDRGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQSDPQ 530

  Fly   477 ----------------YPSFVAAPPTPTPDQMAG---SVRLMRSPTPYPKELRQMSKYVR----- 517
                            .|..|||..|..| .::|   .:.|.|.|||||::|:.|.|.|:
  Rat   531 LAWGCISGLQQERSMCAPLPVAAQSTTLP-SLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGK 594

  Fly   518 -----QAQAATSSANASE-----------------------VREARVVTNGQI------------ 542
                 :.:.|..:||..:                       |..|..:..|::
  Rat   595 PSHGVRVENANPTANTEQTVKEKFEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPP 659

  Fly   543 ---------------------HCDSNNAN--------------------------QDVVDQATTS 560
                                 ||.:|:.:                          |.....|..:
  Rat   660 KLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSASSNTRVKVGSLQPTTKDAVHN 724

  Fly   561 AIYG--IAPETTHIYGVYQQPQQMAHPVPTQEYYGLPLVNYE-------------------AHYQ 604
            :::|  |||.       :.||.. |.|:.||. ..:|..|..                   :||.
  Rat   725 SLWGNRIAPP-------FPQPLD-AKPLLTQR-EAVPPGNLPQRPDRLPMSDAFPDNWTDGSHYD 780

  Fly   605 Q---LYVEA------NTPLPTTHLNGDQDYELQPLQQQ------PM---QQQALPTPRLEPPPYH 651
            .   :..||      |.||.::.......:..:||.:|      |:   |.....||..|.||.:
  Rat   781 NTGFVSEEATGENANNNPLLSSKARSVPAHGRRPLIRQERIVGVPLELEQSTHRHTPETEVPPSN 845

  Fly   652 IARVYTKKTP---EDLNLYES----------MRQRKQQQQLQEQT----------IYQDALNSNS 693
            ..:.:| :||   ||...:.|          :.:||...:...:|          .|.|...:.|
  Rat   846 PWQNWT-RTPSPFEDRTAFPSKLETTPTTSPLPERKDHMKEPTETPGPFSPGVPWEYHDPTPNRS 909

  Fly   694 NFKT---------TAIGAQDVEESVDQLDYQNNISNNLEPNPEEEDQELD--DTMSQHSLNSTAT 747
            ....         ::.|...:.:|.::|   :.:..:::.|..::.|.:|  |..:....|....
  Rat   910 LGNVFSQIHCRPDSSKGVIAISKSTERL---SPLMKDIKSNKFKKSQSIDEIDVGTYKVYNIPLE 971

  Fly   748 NNTSKASHKKSTWIFGVHKNP 768
            |..|.:.|      .|.|:.|
  Rat   972 NYASGSDH------LGSHERP 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_001188938.1	LRR_RI	<21..200	CDD:238064	98/179 (55%)
		leucine-rich repeat	21..41	CDD:275380	9/20 (45%)
		LRR_8	40..98	CDD:290566	29/57 (51%)
		leucine-rich repeat	42..64	CDD:275380	12/21 (57%)
		leucine-rich repeat	65..87	CDD:275380	10/21 (48%)
		LRR_8	86..140	CDD:290566	21/53 (40%)
		leucine-rich repeat	88..110	CDD:275380	9/21 (43%)
		leucine-rich repeat	111..133	CDD:275380	9/21 (43%)
		leucine-rich repeat	134..156	CDD:275380	15/21 (71%)
		LRR_8	156..213	CDD:290566	36/56 (64%)
		leucine-rich repeat	157..179	CDD:275380	16/21 (76%)
		leucine-rich repeat	180..202	CDD:275380	13/21 (62%)
		leucine-rich repeat	203..225	CDD:275380	11/21 (52%)
		leucine-rich repeat	226..248	CDD:275380	4/21 (19%)
		leucine-rich repeat	272..294	CDD:275380	10/21 (48%)
		LRR_8	279..328	CDD:290566	25/48 (52%)
		leucine-rich repeat	295..317	CDD:275380	12/21 (57%)
		leucine-rich repeat	318..340	CDD:275380	11/21 (52%)
		LRR_8	340..396	CDD:290566	21/55 (38%)
		leucine-rich repeat	364..386	CDD:275380	8/21 (38%)
		PDZ_signaling	770..846	CDD:238492
Lrrc7	NP_001380603.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	405	1.000	Inparanoid score	I1844
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto96758
orthoMCL	1	0.900	-	-		OOG6_105355
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870