DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lap1 and Scrib

DIOPT Version :9

Sequence 1:	NP_001188938.1	Gene:	Lap1 / 36670	FlyBaseID:	FBgn0033984	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_598850.1	Gene:	Scrib / 105782	MGIID:	2145950	Length:	1665	Species:	Mus musculus

Alignment Length:	910	Identity:	258/910 - (28%)
Similarity:	402/910 - (44%)	Gaps:	178/910 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KCFPCFKFKREEVIDKLDYSNTPLTDFP-EVWQHERTLEELYLSTTRLQALPPQLFYCQGLRVLH 69
            ||.|.::..|.  ::.:|..:..|...| |::::.|:||||.|...:|:.||...|....||.|.
Mouse     3 KCIPLWRCNRH--VESVDKRHCSLQVVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLG 65

  Fly    70 VNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITSLISL 134
            ::.|.::.:|..:.:..||..||::||.|..:||.||.||.|...|.|.|.|.||||..|.|.||
Mouse    66 LSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSL 130

  Fly   135 QELLLNETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPEVVGE 199
            ..|.||:..|:.||.:.|.|.||..||||.|.|.:||.|:..|:.|::||:|||:...||:.:|.
Mouse   131 AHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA 195

  Fly   200 LKSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAFPF 264
            |.:|||||:|.||:..:...:|.||.|...:.:.|.|:.||.||.....:..|.:..|.|:..|.
Mouse   196 LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPVELGGLALLTDLLLSQNLLQRLPE 260

  Fly   265 SVGMLKSLVTFKCESNGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLFADDNQLR 329
            .:|.||.|...|.:.|.|.|:.::|...|.|.||:|:.|.|..||.::|.|..|..|..|.|.|.
Mouse   261 GIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLTALPHSLGKLTKLTNLNVDRNHLE 325

  Fly   330 QLPDELCSCQQLSVLSVANNQLSALPQNIGNLSKMKVLNVVNNYINALPVSMLNLVNLTSMWLSD 394
            .||.|:..|..|||||:.:|:|:.||..:.:.:::.||:|..|.:.:||.::.:| ||.::||::
Mouse   326 VLPPEIGGCVALSVLSLRDNRLAVLPPELAHTAELHVLDVAGNRLRSLPFALTHL-NLKALWLAE 389

  Fly   395 NQSQPLVPLQYL-DAST-KTQLTCFMLPQVTFKMNSIQAQQQAQEQYEFVYANQQQPHAS----P 453
            ||:||::..|.. ||.| :..|||::|||     ..:.:.:.|        ..|..|..|    |
Mouse   390 NQAQPMLRFQTEDDAQTGEKVLTCYLLPQ-----QPLPSLEDA--------GQQSSPSESCSDAP 441

  Fly   454 SRRICFAE-EATILSNAKAQPAPNYPSFVAAPPTPTPDQMAGSVR-LMRSPTPYPKELRQMSKYV 516
            ..|:...: |.|:.....|:.|                  |...| |.|..||:|.||:.|.:.:
Mouse   442 LSRVSVIQFEDTLEGEEDAEEA------------------AAEKRGLQRRATPHPSELKVMKRGI 488

  Fly   517 RQAQ----------------------AATSSANASEVREARVVTNGQIHCDSNNANQDVVDQATT 559
            .:.:                      :|.|:.:...|..|...:.|:
Mouse   489 EERRNEAFVCKPDPSPPSPSEEEKRLSAESALSGGSVPSASTASEGE------------------ 535

  Fly   560 SAIYGIAPE--TTHIYGVYQQPQQMAHPVPTQEYYGLPLVNY---------EAHYQQLYVEANTP 613
                   ||  ...:.|:.|.....|....|::.|..|.|::         :...::...||..|
Mouse   536 -------PEILPAEVQGLGQHEAMPAQEEYTEDDYNEPTVHFAEDTLIPREDGESEEGQPEAAWP 593

  Fly   614 LP----------TTHLNGDQDYELQPLQQQPMQQQAL----------PTPRLEPPPY--HIARVY 656
            ||          |.|..  :.:::..| .||....||          ||......|:  ...|.:
Mouse   594 LPSGRQRLIRKDTPHYK--KHFKISKL-PQPEAVVALLQGVQTDREGPTAGWHNGPHTPWAPRAH 655

  Fly   657 TKKTPEDLNLYESMRQRKQQQQLQEQTIYQDALNSNSNFKTTAIGAQDVEESVDQLDYQNNISNN 721
            .::..|:    |..|..::.:...|:...::|:.|..:.|..         |.||       :||
Mouse   656 EEEEEEE----EENRDEEEGEATTEEDDKEEAVASAPSVKGV---------SFDQ-------ANN 700

  Fly   722 LEPNPEE-EDQELDDTMSQHSLNSTATNNTSKASHKKSTWIFGVHKNPTVKQVTLKWENSIGFDI 785
            |...|.. |::||..|:    :..|.....|.|..|.||...|
Mouse   701 LLIEPARIEEEELTLTI----VRQTGGLGISIAGGKGSTPYKG---------------------- 739

  Fly   786 AELLNQVGIFVSSITPNTNAARL-LNLNDKLLEIDGYDLTNANLSDAKRVLLNCGTVMNIMLSRK 849
                :..|||:|.::....|||. :.:.|||||::|..|.:|...:|...|...|..:.:.:.|:
Mouse   740 ----DDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQDAEHHEAVEALRGAGAAVQMRVWRE 800

Fly 850 849
Mouse 801 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_001188938.1	LRR_RI	<21..200	CDD:238064	74/179 (41%)
		leucine-rich repeat	21..41	CDD:275380	4/20 (20%)
		LRR_8	40..98	CDD:290566	21/57 (37%)
		leucine-rich repeat	42..64	CDD:275380	9/21 (43%)
		leucine-rich repeat	65..87	CDD:275380	5/21 (24%)
		LRR_8	86..140	CDD:290566	27/53 (51%)
		leucine-rich repeat	88..110	CDD:275380	11/21 (52%)
		leucine-rich repeat	111..133	CDD:275380	11/21 (52%)
		leucine-rich repeat	134..156	CDD:275380	9/21 (43%)
		LRR_8	156..213	CDD:290566	29/56 (52%)
		leucine-rich repeat	157..179	CDD:275380	11/21 (52%)
		leucine-rich repeat	180..202	CDD:275380	10/21 (48%)
		leucine-rich repeat	203..225	CDD:275380	10/21 (48%)
		leucine-rich repeat	226..248	CDD:275380	7/21 (33%)
		leucine-rich repeat	272..294	CDD:275380	6/21 (29%)
		LRR_8	279..328	CDD:290566	19/48 (40%)
		leucine-rich repeat	295..317	CDD:275380	10/21 (48%)
		leucine-rich repeat	318..340	CDD:275380	9/21 (43%)
		LRR_8	340..396	CDD:290566	20/55 (36%)
		leucine-rich repeat	364..386	CDD:275380	7/21 (33%)
		PDZ_signaling	770..846	CDD:238492	18/76 (24%)
Scrib	NP_598850.1	LRR_RI	12..232	CDD:238064	89/221 (40%)
		leucine-rich repeat	14..37	CDD:275380	4/22 (18%)
		leucine-rich repeat	38..60	CDD:275380	9/21 (43%)
		LRR	39..405	CDD:227223	146/366 (40%)
		leucine-rich repeat	61..83	CDD:275380	5/21 (24%)
		leucine-rich repeat	84..106	CDD:275380	11/21 (52%)
		leucine-rich repeat	107..129	CDD:275380	11/21 (52%)
		leucine-rich repeat	130..152	CDD:275380	9/21 (43%)
		leucine-rich repeat	153..175	CDD:275380	11/21 (52%)
		leucine-rich repeat	176..198	CDD:275380	10/21 (48%)
		leucine-rich repeat	199..221	CDD:275380	10/21 (48%)
		leucine-rich repeat	268..290	CDD:275380	6/21 (29%)
		LRR_4	289..329	CDD:289563	17/39 (44%)
		leucine-rich repeat	291..313	CDD:275380	10/21 (48%)
		leucine-rich repeat	314..336	CDD:275380	9/21 (43%)
		leucine-rich repeat	360..381	CDD:275380	7/21 (33%)
		PDZ	711..799	CDD:214570	28/117 (24%)
		PDZ_signaling	854..933	CDD:238492
		PDZ_signaling	988..1076	CDD:238492
		PDZ_signaling	1085..1175	CDD:238492
		AbLIM_anchor	1565..>1659	CDD:292800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA7S
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820