Protein Alignment Lap1 and lrrd1

DIOPT Version :10

• Sequence 1: NP_611007.1
• Gene: Lap1 / 36670
• FlyBaseID: FBgn0033984
• Length: 849
• Species: Drosophila melanogaster
• Sequence 2: XP_002934640.2
• Gene: lrrd1 / 100490254
• XenbaseID: XB-GENE-985410
• Length: 757
• Species: Xenopus tropicalis
• Alignment Length: 853
• Identity: 200/853 - (23%)
• Similarity: 354/853 - (41%)
• Gaps: 162/853 - (18%)

  Fly    17 EVIDKL------DYSNTPLTDFPEVWQHERTLEELYLSTTRLQALPPQLFYCQGLRVLHVNSNNL 75
            :|.|.|      |.:|.|.|    |.....::..:.|::..|..:||.:|.|..|:.|.:::|.:
 Frog    14 QVEDNLKNLVPSDSNNMPRT----VPSGTGSITSINLNSKELTEIPPDVFRCTNLQCLLLSNNFM 74

  Fly    76 ESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITSLISLQELLLN 140
            ..:|.::..|.:|:.|.|..|.:|::|.||.|...||.|:::.|.:..||..|:.|.::::|..|
 Frog    75 THLPTSLCHLSKLEILSLEGNALVSLPPEICSLSQLTALNVNHNQIAVLPHEISGLKNIKQLFAN 139

  Fly   141 ETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPEVVGELKSLRE 205
            ...|..||...|.|..|::|.:..|::.|||.|...|.||..|::.||:.:.||:.|..|..|.:
 Frog   140 NNKLSQLPPCLGDLTTLQVLCISGNSMKTLPDSTASLKNLHVLNLDGNQISALPKAVFRLSQLVK 204

  Fly   206 LWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAFPFSVGMLK 270
            |.:..|||:.:...||.|::|:....:.|.|..||.:|.|..::|.|::..|.|.|....:..||
 Frog   205 LCLSGNQIKSLPKEIGDLKNLRELSLSSNQLTFLPVQLYNLTSLEELTLDDNKLTAISDKLQNLK 269

  Fly   271 SLVTFKCESNGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLFADDNQLRQLPDEL 335
            .|......:|.||::.:.:.:...:|.|.|:.|::.|||:.|..||:|:.|..:.|.|..|||:|
 Frog   270 QLKVLSIANNLLTDITEKVCWCPAIECLKLNGNQMYRLPTKIHNLRNLKELHIERNALEMLPDQL 334

  Fly   336 CSCQQLSVLSVANNQLSALPQNIGNLSKMKVLNVVNNYINALPVSMLNLVNLTSMWLSDNQSQPL 400
            .....|||:..|||.|..:|..:.|.:::..|::..|.::.:|.::.::.:|..:.|:.|:...:
 Frog   335 AHLNNLSVIVCANNNLLWIPIELKNCNQITKLDLSGNKLSEVPQALSSMTSLLYLNLNQNEIHEI 399

  Fly   401 V-------PLQYLDASTKTQLTCFM--------LPQVTFKMNSIQAQQQAQEQYEFVYANQQQPH 450
            .       .|::|:.| ..:||.|.        |..:....|.|.:...|....|.:  ::...|
 Frog   400 ANSIIHNRKLEHLELS-GNKLTVFSVHFCGLHNLAYLDLSRNEINSVPSAISNLESL--SELLLH 461

  Fly   451 ASPSRRICFAEEATILSNAKAQPAPNYPSFVAAPPTPTPDQMAGSVRLM----RSPTPYPKELRQ 511
            ::..||... |...:.|..|...:.|....|     |:...:...:|.:    .|...:|:||..
 Frog   462 SNKFRRFPI-ELCALKSLQKIDLSGNQIETV-----PSGISLLEGLRYVNLSNNSFKVFPRELFS 520

  Fly   512 MSKYVRQAQAATSSANASEVREARVVTNGQIHCDSNNANQDVVDQATTSAIYGIAPETTHIYGVY 576
            :|        :..:...|:....::::.........|..:..:.......:.|...|..::..:.
 Frog   521 VS--------SLETLKISQKDGRKLISLPDELSKLKNLKELEISDNNIKTLPGSIGEMKNLVQLT 577

  Fly   577 QQPQQMAHPVPTQEYYGLPL-VNYEAHYQQLYVEAN--TPLPTTHLNGDQDYELQPLQQQPMQQQ 638
            ....|:.|         ||. ::..|..|||.::.|  |.|| :.::|     ||.|::..:..
 Frog   578 ATSNQLYH---------LPASISSLAALQQLSLKGNQLTSLP-SDISG-----LQKLREINLDS- 626

  Fly   639 ALPTPRLEPPP--------YHIARVYTKKTPEDLNLYESMRQRKQQQQLQEQTIYQDALNSNSNF 695
               .|.|.||.        |.|.|..                  |...|:::.|.|      ..|
 Frog   627 ---NPMLRPPSLLCDGKRLYPIGRYL------------------QSADLRDEKILQ------KTF 664

  Fly   696 KTTAIGAQDVEESVDQLDYQNNISNNLEPNPEEE-----------DQELDDTMSQHSLNSTATNN 749
            |.                    ||||:   |.|:           |:|:...:...||...
 Frog   665 KL--------------------ISNNI---PAEDFSFFCKKLRIKDEEVKGIVKNRSLQLP---- 702

  Fly   750 TSKASHKKSTWIFGVHKNPTVKQVTLKWEN-----SIGFDIAELLNQVGIFVSSITPNTNAARLL 809
                              ..:.||...|::     :...||||.|.:| :.:..:......|.:.
 Frog   703 ------------------DKILQVLNMWKSERHPQTAPEDIAEQLIRV-LLMCDLHSAALKANVF 748

  Fly   810 NLNDKLLE 817
            .:|.|.::
 Frog   749 KINTKAIK 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lap1	NP_611007.1	LRR	12..407	CDD:443914	120/402 (30%)
		leucine-rich repeat	21..41	CDD:275380	6/25 (24%)
		leucine-rich repeat	42..64	CDD:275380	6/21 (29%)
		leucine-rich repeat	65..87	CDD:275380	5/21 (24%)
		leucine-rich repeat	88..110	CDD:275380	9/21 (43%)
		leucine-rich repeat	111..133	CDD:275380	8/21 (38%)
		leucine-rich repeat	134..156	CDD:275380	7/21 (33%)
		leucine-rich repeat	157..179	CDD:275380	8/21 (38%)
		leucine-rich repeat	180..202	CDD:275380	8/21 (38%)
		leucine-rich repeat	203..225	CDD:275380	8/21 (38%)
		leucine-rich repeat	226..248	CDD:275380	7/21 (33%)
		leucine-rich repeat	272..294	CDD:275380	4/21 (19%)
		leucine-rich repeat	295..317	CDD:275380	9/21 (43%)
		leucine-rich repeat	318..340	CDD:275380	8/21 (38%)
		leucine-rich repeat	364..386	CDD:275380	3/21 (14%)
		PDZ_canonical	778..846	CDD:467153	9/45 (20%)
lrrd1	XP_002934640.2	LRR	1..407	CDD:443914	119/396 (30%)
		leucine-rich repeat	42..63	CDD:275380	6/20 (30%)
		leucine-rich repeat	64..86	CDD:275380	5/21 (24%)
		leucine-rich repeat	87..109	CDD:275380	9/21 (43%)
		leucine-rich repeat	110..132	CDD:275380	8/21 (38%)
		leucine-rich repeat	133..155	CDD:275380	7/21 (33%)
		leucine-rich repeat	156..178	CDD:275380	8/21 (38%)
		leucine-rich repeat	179..201	CDD:275380	8/21 (38%)
		leucine-rich repeat	202..224	CDD:275380	8/21 (38%)
		LRR	222..619	CDD:443914	97/428 (23%)
		leucine-rich repeat	225..247	CDD:275380	7/21 (33%)
		leucine-rich repeat	248..270	CDD:275380	6/21 (29%)
		leucine-rich repeat	271..316	CDD:275380	13/44 (30%)
		leucine-rich repeat	340..385	CDD:275380	12/44 (27%)
		leucine-rich repeat	386..408	CDD:275380	3/21 (14%)
		leucine-rich repeat	409..431	CDD:275380	6/22 (27%)
		leucine-rich repeat	478..500	CDD:275380	4/26 (15%)
		leucine-rich repeat	501..520	CDD:275380	5/18 (28%)
		leucine-rich repeat	550..572	CDD:275380	2/21 (10%)
		leucine-rich repeat	573..595	CDD:275380	4/30 (13%)
		leucine-rich repeat	596..618	CDD:275380	9/27 (33%)
		Death	664..744	CDD:260017	21/125 (17%)