DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IRS1 and chico

DIOPT Version :9

Sequence 1:	NP_005535.1	Gene:	IRS1 / 3667	HGNCID:	6125	Length:	1242	Species:	Homo sapiens
Sequence 2:	NP_001188772.1	Gene:	chico / 64880	FlyBaseID:	FBgn0024248	Length:	968	Species:	Drosophila melanogaster

Alignment Length:	1082	Identity:	246/1082 - (22%)
Similarity:	401/1082 - (37%)	Gaps:	330/1082 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    17 GYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNK 81
            |||:|.|:|.|:||||...:.... ||||||:.|||:..::. |||.|.|::|||||:|.|:|::
  Fly    13 GYLKKLKTMKKKFFVLYEETSTSA-ARLEYYDTEKKFLQRAE-PKRVIYLKNCFNINRRLDTKHR 75

Human    82 HLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAGGGGGSCSGSSGLGEAG 146
            .::.|.:||..|.|..::|.:...|...||.|..                   :.:.|:|...:.
  Fly    76 FVIVLSSRDGGFGIVLENENDLRKWLDKLLVLQR-------------------NIANSNGTAHSP 121

Human   147 EDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSE--------AAA 203
            .|             .||||:::.||:.:...:.|.|..|||||:::||.:..|        .|:
  Fly   122 YD-------------HVWQVVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPEKTPNGEDRVAS 173

Human   204 VVLQLMNIRRCGHS--ENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSD---- 262
            :.:.|..||||||:  :..|::|:||.:|.|.|:.||:.|::.:|.|||.|||.||.|.::
  Fly   174 IEILLTTIRRCGHASPQCIFYVELGRQSVLGSGDLWMETDNAAIATNMHNTILSAMSAKTESNTN 238

Human   263 -----EFRP-------RSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPAS 315
                 :.||       |.:|.|::..|.||:|.:.::       ||..|..||      .:||.:
  Fly   239 LINVYQNRPDLSHEPMRKRSSSANEASKPINVNVIQN-------SQNSLELRS------CSSPHN 290

Human   316 MVGGKPGSFRVRASS--DGEGTMSRPASVDGSPVSPSTNRTHAHRHRG-------SARLHPPLNH 371
            .     |..|.|..|  ...||:|.           |:|:|:...:.|       ..|.|....|
  Fly   291 Y-----GFGRERCDSLPTRNGTLSE-----------SSNQTYFGSNHGLRSNTISGIRPHSTNKH 339

Human   372 SRS--IPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGS- 433
            |.|  ..||. |||.|..|.:|:..|  ..:||.|......|||.:.....:...|.|::.:..
  Fly   340 SNSPTFTMPL-RCSESEESSISVDES--DDNGSFSHYRLNTRSSETAIPEENIDDFASAELFSKV 401

Human   434 ----------------SPCDF-----RSSFRSVTPDSLGHTPPARGEEELS--------NYIC-- 467
                            :|.|.     ::..:.:...||....|....|:|:        |..|
  Fly   402 TEQNVSDENYIPMNPVNPTDAIHEKEKADMQRLEDASLHFNFPEHASEKLAKDFDLDSDNQCCRP 466

Human   468 ------------------MG-----GKGPS---------------------TLTAPNGHYILSRG 488
                              :|     |:.|:                     .|...|.|...:..
  Fly   467 IRAYSIGNKVEHLKFNKRLGHLNDTGQNPNRVRAYSVGSKSKIPRCDLQRVVLVEDNKHEFTANR 531

Human   489 GNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTPSQSSVASIEE--Y 551
            ........||..|:|.              ||.:|.|    ::|.::.:...:...::.:.|  :
  Fly   532 SQSSITKEGTSYGSSA--------------NRQKKST----SAPLLSLKNQINSDRMSDLMEIDF 578

Human   552 TEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRG--GHHRPDSSTLHTDDGYMP 614
            ::..............:|.:..:.|..........|.:|...::.  ...:.:::.:.::|||:.
  Fly   579 SQATNLEKQKFIKNNEIPKYIENVFPKAPRTDSSSLTLHATSQKDIFNGTKLNNTAITSEDGYLE 643

Human   615 MSPGVAPVPSGRKGSGDYMPMSPK--------------SVSAPQQIINPI----------RRHPQ 655
            |.    ||.:|...|.:.:||..:              :.:||...:|.|          |..|.
  Fly   644 MK----PVGNGYTPSSNCLPMKVEKLKLSDYQTAPPLTATAAPVHDLNKISTYNISAEKWREQPS 704

Human   656 RVDPNGYMMMSPSGGCSPDIGGGPSS--SSSSSNAVPSGTSY------------------GKLWT 700
            |.:..    .|.|..........|::  |:|.|:.|.|....                  .|:..
  Fly   705 RSEEK----KSNSPLNDNTFSSKPTNVESTSKSHDVHSANQIDCEKVCAQSSDKLNNHLADKIVE 765

Human   701 NG---VGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVG------DSNTSSPSDCYYGPEDP 756
            |.   :|||....|.|.....:.:  ::...:.|:...:..|      .|::|..|...|  :..
  Fly   766 NNNLDIGGHEEKKLVHSISSEDYT--QIKDKSNDFTKFNEAGYKILQIKSDSSLISSKLY--QKG 826

Human   757 QHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSST---------- 811
            .||.     :|.||.:.|:......:.|                .|||..|||.|
  Fly   827 IHKD-----NLERSQRLTESVNTIPDNA----------------TATAVSSSSLTKFNINSAKPA 870

Human   812 -SSDSLGGGYCGARLEPSLPHPHHQVLQPHLPRKVDTAAQTNSRLARP----TRLSL----GDPK 867
             ::||...|     .:||.|....|:...:.|      ::::||:::|    ..|.|    |...
  Fly   871 AAADSRSTG-----TDPSTPQNILQIKDLNFP------SRSSSRISQPELHYASLDLPHCSGQNP 924

Human   868 ASTLPRAREQQQQQQPLLHPPE---PKSPGEYVNIEFGSDQS 906
            |..|.|...:.        ||.   |:....|..|:|  |||
  Fly   925 AKYLKRGSRES--------PPVSACPEDGNTYAKIDF--DQS 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IRS1	NP_005535.1	Mediates interaction with PHIP. /evidence=ECO:0000250	3..137		43/119 (36%)
		PH_IRS	11..118	CDD:269959	43/100 (43%)
		PTB_IRS	160..263	CDD:269915	44/121 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..430		49/194 (25%)
		YXXM motif 1	465..468		1/22 (5%)
		YXXM motif 2	551..554		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	592..616		3/25 (12%)
		YXXM motif 3	612..615		1/2 (50%)
		YXXM motif 4	632..635		0/2 (0%)
		YXXM motif 5	662..665		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..693		7/26 (27%)
		YXXM motif 6	732..735		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	771..900		30/150 (20%)
		GRB2-binding. /evidence=ECO:0000250	896..898		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..937
		YXXM motif 7	941..944
		YXXM motif 8	989..992
		YXXM motif 9	1012..1015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1057..1146
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1190..1242
chico	NP_001188772.1	PH_IRS	7..112	CDD:269959	43/119 (36%)
		PH	25..104	CDD:278594	33/80 (41%)
		PTB_IRS	122..235	CDD:269915	45/125 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152293
Domainoid	1	1.000	94	1.000	Domainoid score	I7478
eggNOG	1	0.900	-	-		E1_28N3R
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7969
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001178
OrthoInspector	1	1.000	-	-		otm41286
orthoMCL	1	0.900	-	-		OOG6_105771
Panther	1	1.100	-	-	O	PTHR10614
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4611
SonicParanoid	1	1.000	-	-		X1499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.770