DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IRS1 and irs1

DIOPT Version :9

Sequence 1:	NP_005535.1	Gene:	IRS1 / 3667	HGNCID:	6125	Length:	1242	Species:	Homo sapiens
Sequence 2:	XP_687702.4	Gene:	irs1 / 559281	ZFINID:	ZDB-GENE-030131-872	Length:	1099	Species:	Danio rerio

Alignment Length:	1305	Identity:	725/1305 - (55%)
Similarity:	806/1305 - (61%)	Gaps:	278/1305 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASPPESDG-FSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSI 64
            ||||....| ||||:|||||||||||||||||||||| |.||:|||||||||||||||.||||||
Zfish     1 MASPTTEQGCFSDVKKVGYLRKPKSMHKRFFVLRAAS-ASGPSRLEYYENEKKWRHKSGAPKRSI 64

Human    65 PLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGA 129
            ||||||||||||||||||||||||:||:||||||||.||:|||:||:.||||.|.|.   .|.|.
Zfish    65 PLESCFNINKRADSKNKHLVALYTKDEYFAIAADSEIEQESWYEALVDLHNRGKVHE---TAPGR 126

Human   130 GGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISF 194
            |              .||| :||:..|||||||||||||||||||.||||||:||||||:|||||
Zfish   127 G--------------VGED-NYGEATPGPAFKEVWQVILKPKGLGHTKNLIGVYRLCLTNKTISF 176

Human   195 VKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRA 259
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|
Zfish   177 VKLNSDAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMKA 241

Human   260 MSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPG-- 322
            ||:|||||||||||||||||||||:||||.||||||||||.||||.||:|||||.     :||
Zfish   242 MSEEFRPRSKSQSSSNCSNPISVPVRRHHHNNPPPSQVGLGRRSRAESVTATSPV-----RPGKH 301

Human   323 --SFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSARLHPPLNHSRSIPMPASRCSPS 385
              ||||||||||||||||||||||||.|||..|..:.||||.:|||||||||||||.|.||||||
Zfish   302 SHSFRVRASSDGEGTMSRPASVDGSPSSPSNARPQSQRHRGGSRLHPPLNHSRSIPTPTSRCSPS 366

Human   386 ATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSL 450
            |.||:|||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||
Zfish   367 AISPISLSSSSTSGHGSTSDCLFPRRSSASISGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSL 431

Human   451 GHTPPARGEEELSNYICMGGKGPSTLTAPNGHYILSRGGNGHRCTPGTG-------LGTSPALAG 508
            ||||||| |||::|||||...|                     ..||.|       .||...|..
Zfish   432 GHTPPAR-EEEINNYICMAKPG---------------------SLPGAGSQSRSQSRGTPSRLEE 474

Human   509 DEAASAADLDNRFRKRTHSAGTS-PTITHQKTPSQSSVASIEEYTEMMPAYPPGGGSGGRLPGHR 572
            .|      |:..|||||||:|.| ||..||||||||..||:||||.|||.||....:......:|
Zfish   475 PE------LEKCFRKRTHSSGASPPTPCHQKTPSQSPAASLEEYTVMMPTYPRSRSASSSSSTYR 533

Human   573 HSAFVPTRSYPEEGLEMHPLERRGGHHRPDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSP 637
            || |:||.||||||.:....:...|   ||    |.|||||||.|||||.....| |.|||||||
Zfish   534 HS-FMPTHSYPEEGTDASQAKDERG---PD----HKDDGYMPMLPGVAPATPTTK-SSDYMPMSP 589

Human   638 KSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNG 702
            |||||||||||| |:| ..||.||||||||||.||||                ..|:|||:||||
Zfish   590 KSVSAPQQIINP-RQH-SHVDSNGYMMMSPSGSCSPD----------------GTTNYGKIWTNG 636

Human   703 VGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGP-EDPQHKPVLSYYS 766
            :         :||..|||..||:..| |||:||||...|.||:|.||::.| |||. :|:.:|||
Zfish   637 I---------NPKLSVESMEGKVSSC-GDYINMSPASCSTTSTPPDCFFNPVEDPP-RPMYAYYS 690

Human   767 LPRSFKHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPH 831
            |||||||..|..:      ...||:|..|.||.|   ||.||||.|||||||          ..:
Zfish   691 LPRSFKHANRKQD------QSPLRVSLGSSRLAY---ADSSSSSASSDSLGG----------QSN 736

Human   832 PHHQVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEY 896
            .....::|       ..::.|.||.|||||||...|||||||.||..       .||||||||||
Zfish   737 SQQSAVKP-------KRSEGNGRLTRPTRLSLDASKASTLPRTRESP-------FPPEPKSPGEY 787

Human   897 VNIEFG----SDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQE- 956
            |||||.    |.....|..||  :|......||.|         .:.|||.|.||...|....|
Zfish   788 VNIEFNDKAFSASLASLFPPV--YSVSDAEAPSDL---------SSSEYMNMQLGSQARRLCSEL 841

Human   957 ---STGVEMGRLGP-----APP-GAASICRPTRAVPSSRGDYMTMQM-SCPRQSYVDTSPAAPVS 1011
               |:..:...:.|     :|| ...|||         ..||::||: ||             ..
Zfish   842 QTSSSSSDYAIITPSNSVSSPPLPCESIC---------ERDYISMQLASC-------------TG 884

Human  1012 YADMRTGIAAEEVSLPRATMAAASSSSAASASPTGPQGAAELAAH--SSLLGGPQGP------GG 1068
            :.|.:..:..|  :||.|      .:...|.||.          |  ::|.|.|..|      .|
Zfish   885 FPDTQLMLMTE--ALPDA------DAPPCSVSPN----------HDVTTLSGAPGRPALISPLSG 931

Human  1069 MSAFTRVNLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSS 1133
            :|||||||.:..|||.|||||||||| |||||||||:||  |||              |...:||
Zfish   932 LSAFTRVNSTSGRNQGAKVIRADPQG-RRRHSSETFAST--ATR--------------GSVDTSS 979

Human  1134 S--SEDVKRHSSASFENVWLRPGELGGAPKEPAKLCGAAGGLE--------------NGLNYIDL 1182
            :  |.|||||||||||||||||.:...|...|:......|..|              ||||||||
Zfish   980 TCQSGDVKRHSSASFENVWLRPDQASAASTAPSASTVTNGRRETASGQIPTLTNHDQNGLNYIDL 1044

Human  1183 DLVKDFKQCPQECTPEPQPPPPPPPHQP-----------LGSGESSSTRRSSEDLSAYASISFQK 1236
            ||:::.:|                 |.|           ||:.|      ..|:|||||||:|||
Zfish  1045 DLMQNGEQ-----------------HVPDWNAFQSRPVELGAVE------GIEELSAYASINFQK 1086

Human  1237 QPEDR 1241
            ..|.|
Zfish  1087 SDETR 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IRS1	NP_005535.1	Mediates interaction with PHIP. /evidence=ECO:0000250	3..137		103/134 (77%)
		PH_IRS	11..118	CDD:269959	94/106 (89%)
		PTB_IRS	160..263	CDD:269915	97/102 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..430		140/171 (82%)
		YXXM motif 1	465..468		2/2 (100%)
		YXXM motif 2	551..554		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	592..616		10/23 (43%)
		YXXM motif 3	612..615		2/2 (100%)
		YXXM motif 4	632..635		2/2 (100%)
		YXXM motif 5	662..665		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..693		6/24 (25%)
		YXXM motif 6	732..735		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	771..900		56/128 (44%)
		GRB2-binding. /evidence=ECO:0000250	896..898		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..937		3/18 (17%)
		YXXM motif 7	941..944		2/2 (100%)
		YXXM motif 8	989..992		1/2 (50%)
		YXXM motif 9	1012..1015		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1057..1146		51/96 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1190..1242		19/63 (30%)
irs1	XP_687702.4	PH_IRS	12..118	CDD:269959	94/106 (89%)
		PH	14..113	CDD:278594	88/99 (89%)
		PTB_IRS	142..245	CDD:269915	97/102 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194326508
Domainoid	1	1.000	759	1.000	Domainoid score	I916
eggNOG	1	0.900	-	-		E1_28N3R
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4049
Inparanoid	1	1.050	1164	1.000	Inparanoid score	I1723
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40234
OrthoDB	1	1.010	-	-		D154392at33208
OrthoFinder	1	1.000	-	-		FOG0001178
OrthoInspector	1	1.000	-	-		oto42834
orthoMCL	1	0.900	-	-		OOG6_105771
Panther	1	1.100	-	-	LDO	PTHR10614
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4611
SonicParanoid	1	1.000	-	-		X1499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300