DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IRS1 and Irs1

DIOPT Version :9

Sequence 1:	NP_005535.1	Gene:	IRS1 / 3667	HGNCID:	6125	Length:	1242	Species:	Homo sapiens
Sequence 2:	NP_037101.2	Gene:	Irs1 / 25467	RGDID:	2922	Length:	1235	Species:	Rattus norvegicus

Alignment Length:	1248	Identity:	1114/1248 - (89%)
Similarity:	1145/1248 - (91%)	Gaps:	19/1248 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIP 65
            |||||::||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIP 65

Human    66 LESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAG 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||    .|
  Rat    66 LESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGA----GG 126

Human   131 GGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFV 195
            |.|||||||||:||||||||| |..||||||||||||||||||||||||||||||||||||||||
  Rat   127 GCGGSCSGSSGVGEAGEDLSY-DTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFV 190

Human   196 KLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAM 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   191 KLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAM 255

Human   261 SDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFR 325
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   256 SDEFRPRSKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFR 320

Human   326 VRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSARLHPPLNHSRSIPMPASRCSPSATSPV 390
            |||||||||||||||||||||||||||||||||||||:|||||||||||||||:|||||||||||
  Rat   321 VRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPV 385

Human   391 SLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPP 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   386 SLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPP 450

Human   456 ARGEEELSNYICMGGKGPSTLTAPNGHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNR 520
            |||||||||||||||||.||||||||||||||||||||..||..:||||||.|||||.|||||||
  Rat   451 ARGEEELSNYICMGGKGASTLTAPNGHYILSRGGNGHRYIPGATMGTSPALTGDEAAGAADLDNR 515

Human   521 FRKRTHSAGTSPTITHQKTPSQSSVASIEEYTEMMP-AYPPGGGSGGRLPGHRHSAFVPTRSYPE 584
            ||||||||||||||:||||||||||.|||||||||| ||||||||||||||:||||||||.||||
  Rat   516 FRKRTHSAGTSPTISHQKTPSQSSVVSIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPE 580

Human   585 EGLEMHPLERRGGHHRPDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINP 649
            ||||||.|||||||||||||.|||||||||||||||||||.|||:||||||||||||||||||||
  Rat   581 EGLEMHHLERRGGHHRPDSSNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINP 645

Human   650 IRRHPQRVDPNGYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHP 714
            ||||||||||||||||||||.|||||||| |.||||.:|.|||:||||.|||||||||:|.|||.
  Rat   646 IRRHPQRVDPNGYMMMSPSGSCSPDIGGG-SCSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHA 709

Human   715 KPPVESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGE 779
            ||||||.||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||
  Rat   710 KPPVESGGGKLLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGE 774

Human   780 PEEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHLPRK 844
            |||||||||||||:|||||.|.|||:|||||||||||||||||||.|.|:.||||..||||||||
  Rat   775 PEEGARHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSVTHPHHHALQPHLPRK 839

Human   845 VDTAAQTNSRLARPTRLSLGDPKASTLPRARE----QQQQQQPLLHPPEPKSPGEYVNIEFGSDQ 905
            |||||||||||||||||||||||||||||.||    ||||||..|||||||||||||||||||.|
  Rat   840 VDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQQQQQSSLHPPEPKSPGEYVNIEFGSGQ 904

Human   906 SGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGVEMGRLGPAPP 970
            .|||:||....|||||||..||.|||| ||||:||||.|||||||||.||||.|||:||:|||||
  Rat   905 PGYLAGPATSRSSPSVRCLPQLHPAPR-EETGSEEYMNMDLGPGRRATWQESGGVELGRVGPAPP 968

Human   971 GAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIAAEEVSLPRATMAAAS 1035
            ||||||||||:||:|||||||||:.|||||||||||.|||||||||||||||:|||||.|.||..
  Rat   969 GAASICRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKVSLPRTTGAAPP 1033

Human  1036 SSSAASASPT-GPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPNRNQSAKVIRADPQGCRRRH 1099
            .||.||||.: .||||||.|||||||||||||||||||||||||||.||||||||||.|||||||
  Rat  1034 PSSTASASASVTPQGAAEQAAHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRH 1098

Human  1100 SSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKRHSSASFENVWLRPGELGGAPKEPA 1164
            ||||||   :.||.||||.||||||   ||||...||||||||||||||||||||:||||.||.|
  Rat  1099 SSETFS---APTRAGNTVSFGAGAA---GGGSGGGSEDVKRHSSASFENVWLRPGDLGGASKESA 1157

Human  1165 KLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQPPPPPPPHQPLGSGESSSTRRSSEDLSAY 1229
            ...|||||||..|||||||||||.||.||:|..:.|..|||||||||||.|.||.||||||||.|
  Rat  1158 PGYGAAGGLEKSLNYIDLDLVKDVKQHPQDCPSQQQSLPPPPPHQPLGSNEGSSPRRSSEDLSTY 1222

Human  1230 ASISFQKQPEDRQ 1242
            |||:|||||||||
  Rat  1223 ASINFQKQPEDRQ 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IRS1	NP_005535.1	Mediates interaction with PHIP. /evidence=ECO:0000250	3..137		124/133 (93%)
		PH_IRS	11..118	CDD:269959	106/106 (100%)
		PTB_IRS	160..263	CDD:269915	102/102 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..430		164/167 (98%)
		YXXM motif 1	465..468		2/2 (100%)
		YXXM motif 2	551..554		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	592..616		22/23 (96%)
		YXXM motif 3	612..615		2/2 (100%)
		YXXM motif 4	632..635		2/2 (100%)
		YXXM motif 5	662..665		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..693		18/24 (75%)
		YXXM motif 6	732..735		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	771..900		115/132 (87%)
		GRB2-binding. /evidence=ECO:0000250	896..898		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..937		14/18 (78%)
		YXXM motif 7	941..944		2/2 (100%)
		YXXM motif 8	989..992		2/2 (100%)
		YXXM motif 9	1012..1015		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1057..1146		73/88 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1190..1242		38/51 (75%)
Irs1	NP_037101.2	Mediates interaction with PHIP. /evidence=ECO:0000269\|PubMed:11018022	3..133		124/133 (93%)
		PH_IRS	11..118	CDD:269959	106/106 (100%)
		PTB_IRS	155..258	CDD:269915	102/102 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..425		163/166 (98%)
		YXXM motif 1	460..463		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..539		17/18 (94%)
		YXXM motif 2	546..549		2/2 (100%)
		YXXM motif 3	608..611		2/2 (100%)
		YXXM motif 4	628..631		2/2 (100%)
		YXXM motif 5	658..661		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	669..720		40/51 (78%)
		YXXM motif 6	727..730		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..921		130/154 (84%)
		GRB2-binding	895..897		1/1 (100%)
		YXXM motif 7	939..942		2/2 (100%)
		YXXM motif 8	987..990		2/2 (100%)
		YXXM motif 9	1010..1013		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1165		114/146 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1177..1235		43/57 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83679216
Domainoid	1	1.000	1741	1.000	Domainoid score	I410
eggNOG	1	0.900	-	-		E1_28N3R
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4049
Inparanoid	1	1.050	2232	1.000	Inparanoid score	I1091
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40234
OrthoDB	1	1.010	-	-		D154392at33208
OrthoFinder	1	1.000	-	-		FOG0001178
OrthoInspector	1	1.000	-	-		oto137095
orthoMCL	1	0.900	-	-		OOG6_105771
Panther	1	1.100	-	-	LDO	PTHR10614
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1499
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270